DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tej and Rnf17

DIOPT Version :9

Sequence 1:	NP_610950.2	Gene:	tej / 36590	FlyBaseID:	FBgn0033921	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001028215.1	Gene:	Rnf17 / 30054	MGIID:	1353419	Length:	1640	Species:	Mus musculus

Alignment Length:	632	Identity:	117/632 - (18%)
Similarity:	227/632 - (35%)	Gaps:	196/632 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DGGELSLVKKVVHSLVVSSPGKLTV------------EQLMRDYRSEEGCTL--PYSKLGF-KDA 52
            :|.:....|::|   ||:||..:.|            |:::.:  :.|.|..  |....|: |..
Mouse   366 EGKKKQPTKEMV---VVTSPKTIAVLPQLGSSPDVIIEEIIEE--NLESCFTDDPIETSGYPKKP 425

  Fly    53 ESFLRSIPDTVTVTGHGQMAWITAVA------TAKSAHIQKLVRCQKKSK---NRGSHKPKYCYA 108
            ....:|.| ..:..|..::.:::.|.      ..|.:.|:.....:||.|   ||..|
Mouse   426 PQKEQSAP-VGSKAGCPELVFVSHVIHPCHFYVRKYSQIKDATILEKKMKQVCNRSLH------- 482

  Fly   109 SEPSNL------VFINESVSKMKNRK--APFPTYQVP---RNLKLPVSYPNYNRL------LYPV 156
            .:||::      :|:|    .:|||.  ....|..:|   :|::.|.|...::..      ::.|
Mouse   483 LDPSDILELGARIFVN----SIKNRMWCRGIITEIIPSKTKNIRKPCSPTKFSVCEISLIQIFMV 543

  Fly   157 HTPHIDQMISTGQQQSTLRTQRPSFPCNANSKSLKVNDWSQKDRKQEPSKERNNQKYPKITTEN- 220
            ...:.:.:|.||                       |.|..:       ..|.:.:::  ||..:
Mouse   544 DFGNSEVLIITG-----------------------VGDTHE-------GPEHDGEQH--ITLSDF 576

  Fly   221 -----KQEKETEELAQAFENLSVDVAPTDHQEKLKCEIYEDNEDEFVRDPFIYGEVKEKEDEAVV 280
                 |.|..:|||.:       |:....|...||             |...|...:..|.||.|
Mouse   577 CLLLMKSEPYSEELLK-------DIPHLAHLCSLK-------------DIVPYNSTEGWEKEAKV 621

  Fly   281 LAFDAVSEDGFDLLSMTTTQQNAVKPLDPPEDCLHYASSDDGEDENAIPAYAVDHRVLDVDY--- 342
                       :.|.|...:...:|..              ||:::          ||.||.
Mouse   622 -----------EFLKMVNKKAVLMKVF--------------GEEDD----------VLIVDLQKP 651

  Fly   343 PRDAVRSAFTLPARDIESIIELQQ----------------------------RIRVQLVSLVNPH 379
            |.:.:.|...:..||....:||.:                            .:.|.:..:.:|.
Mouse   652 PTNKISSDMPVSLRDALVFMELARFRSQSPRSHSEKNTTLCYHPPILPEEMTEVSVMVCHINSPT 716

  Fly   380 NFNFWIYNDDFKDYEAQFANMQTFYESSESKNYTM--PLFLITTDHLCVVRCTSG-WERAKVLGY 441
            :|...:..:  .|:.:....::.||:..:.:|..:  ||    .:..||.:...| |.||||:|.
Mouse   717 DFYLQLMEN--LDFLSLLKTIEEFYKGEDGENLEILCPL----QNQACVAKFEDGIWYRAKVIGL 775

  Fly   442 RSSNNKMTIEVELVDIGDIIRVSQQNVKFLIKPFALLPRQCLAGRLAFITQCKSPNWTAEVVNFF 506
            .....   :||:.||.|:..:::.::::.:...|...|.:.:..:||::...|...|:.:....|
Mouse   776 PGHRE---VEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEPSKKSQWSKKAKEKF 837

  Fly   507 HDMILLRLLYAKV-EAIKNNTAYLVLVDTESQGHT-VNLNRSLIETG 551
            .:....:.:...| :.::||...:.|.|:.:.|.: |::|..|::.|
Mouse   838 EEKTQDKFVTCSVIKILENNVLLVELFDSRAPGKSAVSINDQLVKEG 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tej	NP_610950.2	LOTUS_TDRD_OSKAR	7..93	CDD:193586	19/106 (18%)
tej	NP_610950.2	TUDOR	379..488	CDD:278965	23/111 (21%)
Rnf17	NP_001028215.1	iSH2_PI3K_IA_R	158..>242	CDD:304922
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..376		2/9 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..435		5/22 (23%)
		TUDOR	444..>551	CDD:278965	22/117 (19%)
		TUDOR	698..819	CDD:278965	25/129 (19%)
		TUDOR	755..801	CDD:119391	14/48 (29%)
		TUDOR	937..1053	CDD:278965
		TUDOR	990..1036	CDD:119391
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1170..1191
		TUDOR	1196..1312	CDD:278965
		TUDOR	1250..1295	CDD:119391
		TUDOR	1426..1567	CDD:278965
		TUDOR	1501..1548	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810