DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tej and TDRD7

DIOPT Version :9

Sequence 1:	NP_610950.2	Gene:	tej / 36590	FlyBaseID:	FBgn0033921	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_055105.2	Gene:	TDRD7 / 23424	HGNCID:	30831	Length:	1098	Species:	Homo sapiens

Alignment Length:	691	Identity:	146/691 - (21%)
Similarity:	251/691 - (36%)	Gaps:	204/691 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ELSLVKKVVHSLVVSSPGKLTVEQLMRDYRSEEGCTLPYSKLGFKDAESFLRSIPDTVTV-TGHG 69
            |..||.|::.:::.|....:.:.:|..:|||..|..:|:.:|||...|::|||:|..|.: |...
Human     3 EGDLVSKMLRAVLQSHKNGVALPRLQGEYRSLTGDWIPFKQLGFPTLEAYLRSVPAVVRIETSRS 67

  Fly    70 QMAWITAVATAKSAHIQKLVRCQKKSKNRGSHKPKYCYASEPSNLVFINESVSKMKNR------- 127
            ......|:|..::|.|.:||..|:.|| |.:.:...|.......:.|..|...|...|
Human    68 GEITCYAMACTETARIAQLVARQRSSK-RKTGRQVNCQMRVKKTMPFFLEGKPKATLRQPGFASN 131

  Fly   128 ----KAPFPTYQVPRNLKLPVSYPNYNRLLYPVHTP-------------HIDQMISTGQQQSTLR 175
                |.|.|.....:...:.|. |:.....|.:||.             |:  .:||..:.|...
Human   132 FSVGKKPNPAPLRDKGNSVGVK-PDAEMSPYMLHTTLGNEAFKDIPVQRHV--TMSTNNRFSPKA 193

  Fly   176 TQRPSFPCNANSKSLK-----VNDWSQKDRKQEPS-----------------KERNN----QKYP 214
            :.:|....:.:..|.|     :|...:|...:.|:                 .:.||    .|.|
Human   194 SLQPPLQMHLSRTSTKEMSDNLNQTVEKPNVKPPASYTYKMDEVQNRIKEILNKHNNGIWISKLP 258

  Fly   215 KITTENKQEKETEELAQAFEN----LSVD----------VAPTDHQEKLKCEIYEDNEDEFVRDP 265
            ....|..:|...:.:.|.||:    .:|:          :.|...::.|:.|:   :.::....|
Human   259 HFYKELYKEDLNQGILQQFEHWPHICTVEKPCSGGQDLLLYPAKRKQLLRSEL---DTEKVPLSP 320

  Fly   266 F---------------IYGEVKEKEDEAVV------------LAFDAVSEDGFDLLSMTTTQQNA 303
            .               :.|:.|||..:.:|            .||:.:.:..|
Human   321 LPGPKQTPPLKGCPTVMAGDFKEKVADLLVKYTSGLWASALPKAFEEMYKVKF------------ 373

  Fly   304 VKPLDPPEDCL-HYASSDDGEDENAIPAYAVDHRVLDVDY----PRDAVRSA-FTLPA------- 355
                  |||.| :.||..|               |..:||    |:.|:..| ..||.
Human   374 ------PEDALKNLASLSD---------------VCSIDYISGNPQKAILYAKLPLPTDKIQKDA 417

  Fly   356 ------RDIESIIELQQRIRVQ---------------------------LVSLVNPHNFNFWIYN 387
                  .||::::| |:.::|:                           .|.:|...|.|..:..
Human   418 GQAHGDNDIKAMVE-QEYLQVEESIAESANTFMEDITVPPLMIPTEASPSVLVVELSNTNEVVIR 481

  Fly   388 DDFKDYEAQFANMQTFYESSESKNYTM-PLFLITTDHLCVVRC-TSGWERAKVLGYRSSNNKMTI 450
            ...|||.|....|:...:...|||..: |:..:....|..|.. ...|.||:|:.  :..||  |
Human   482 YVGKDYSAAQELMEDEMKEYYSKNPKITPVQAVNVGQLLAVNAEEDAWLRAQVIS--TEENK--I 542

  Fly   451 EVELVDIGDIIRVSQQNVKFLIKPFALLPRQCLAGRLAF-ITQCKSPNWTAEVVNFFHDMILL-- 512
            :|..||.|     ..:||: ..|.:.|.|:.|   .|:| .|:||...  .||::...|::.:
Human   543 KVCYVDYG-----FSENVE-KSKAYKLNPKFC---SLSFQATKCKLAG--LEVLSDDPDLVKVVE 596

  Fly   513 RLLYAKVEAI----KNNTAYLVLVDTESQGHTVNLNRSLIE 549
            .|...|:.|:    |.:...:||.||..: ..:|:|.:.::
Human   597 SLTCGKIFAVEILDKADIPLVVLYDTSGE-DDININATCLK 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tej	NP_610950.2	LOTUS_TDRD_OSKAR	7..93	CDD:193586	26/86 (30%)
tej	NP_610950.2	TUDOR	379..488	CDD:278965	30/110 (27%)
TDRD7	NP_055105.2	LOTUS_1_TDRD7	4..91	CDD:193600	26/86 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..156		5/27 (19%)
		LOTUS_2_TDRD7	234..300	CDD:193587	10/65 (15%)
		LOTUS_3_TDRD7	338..404	CDD:193588	20/98 (20%)
		TUDOR	459..581	CDD:278965	37/134 (28%)
		TUDOR	517..559	CDD:119391	15/51 (29%)
		TUDOR	648..775	CDD:278965
		TUDOR	707..752	CDD:119391
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	855..874
		Interaction with CDK17. /evidence=ECO:0000250	861..1098
		Interaction with CABLES1. /evidence=ECO:0000250	893..1098
		TUDOR	909..1026	CDD:278965
		TUDOR	963..1007	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	40	1.000	Domainoid score	I12541
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900