DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tej and Tdrd5

DIOPT Version :9

Sequence 1:	NP_610950.2	Gene:	tej / 36590	FlyBaseID:	FBgn0033921	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001128213.1	Gene:	Tdrd5 / 214575	MGIID:	2684949	Length:	1040	Species:	Mus musculus

Alignment Length:	690	Identity:	146/690 - (21%)
Similarity:	244/690 - (35%)	Gaps:	192/690 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VKKVVHSLVVSSPGKLTVEQLMRDYRSEEGCTLPYSKLGFKDAESFLRSIPDTVTVT--GHGQMA 72
            ::|.:.||::|:...||.:||.::|....|..||...||::.....:..:||.|:|.  |.|.:.
Mouse    11 LRKEIRSLLISTKDGLTPQQLEKEYLLMVGNHLPLRILGYRSTMELVLDMPDVVSVCPGGDGTVI 75

  Fly    73 WITAVATAKSAHIQKLVRCQKKSKNRGSHK---------PKYCYASEP----------------- 111
             :.|:....:..|..||     :|.|.|||         |..|....|
Mouse    76 -LKAIPDESTKGIASLV-----AKQRRSHKVRNSMPKGRPSICSGRVPYRGRVPPILPAVVKSEL 134

  Fly   112 ------------------------------------------------------SNLVFINESVS 122
                                                                  .:|:.:.:|||
Mouse   135 KDLLALSPVLLSDFEKAFARRFGRSFQYMQYGFLSMFEVLNAASDVISVEQTRAGSLLTLKKSVS 199

  Fly   123 KMKNRKAPF-PTYQVPRNLKLPVSYPNYNRLLYPVHTPHIDQMISTGQ--QQSTLRTQRPSFPCN 184
            :.|.|..|. ..:..|..:|...||...    :||...|..|.||..:  :|.....:.|:|
Mouse   200 EDKQRGWPAGKVFTQPFRMKQQGSYSTG----FPVMKAHFSQPISNMEPPKQVLSMAKTPTF--- 257

  Fly   185 ANS-KSLKVNDWSQKDRKQ----------------EPSKERNNQ----KYP------KITTE--- 219
             || ::.::|...:.::.:                :|..:|..|    |:|      |:..|
Mouse   258 -NSVEASRLNHTEKLNQLESTFKSVIAQIGPGGTVDPELKRKIQFVVSKFPQGLFISKLLGEFEL 321

  Fly   220 -NKQEKETEELAQAFENLSVDVAPTDHQEKLKCEIYEDNEDEFVRD----PFIYGEVKEKEDEAV 279
             .|::...::|  .|.|::..|...  .:.|:.|..|:.:|..|.|    |...|........:.
Mouse   322 TFKEQLSPKQL--GFLNVTELVGAL--SDILRVEFSEERQDLLVFDADLKPLPSGGPLSSVRNSC 382

  Fly   280 VLAFDAVSEDGFDLLSMTTTQQNAVKPLDPPEDCLHYASSDDGEDENAI---PAYAVDHRVLDV- 340
            ::..|..:|......|::....:.|.......||   ...:..|.|..|   |...|....|.|
Mouse   383 LVQPDKKTEANPWTSSLSRNSLSTVAVKKTTWDC---PLKNQKEPEQKIYKKPNLVVKPLQLQVE 444

  Fly   341 -------------DYPRDAVRS--AFTLPARDIESIIELQQRIRVQLVSLVNPHNFNFWIYNDDF 390
                         |.|.||||:  ...||..|..::      :.|.:..:::|..|...||:.|.
Mouse   445 TNKPQLSLSVANHDIPPDAVRAKKLCRLPPLDTSTL------VGVFVEYIISPSQFYIRIYSRDS 503

  Fly   391 KD-YEAQFANMQTFYESS-ESKNYTMPLFLITTDHLCVVRCTSG--WERA---KVLGYRSSNNKM 448
            .: .|.....|:..|.:. .|..|.||.:.|...|||.|:.:..  |.|.   ::||      |.
Mouse   504 SELLEDMMIEMRRCYSNQLVSDRYIMPEYFIQPGHLCCVKISEDKWWYRVIIHRILG------KK 562

  Fly   449 TIEVELVDIGDIIRVSQQNVKFLIKPFALLPRQCLAGRLAFITQCKSPNWTAEVVNFFHDMILLR 513
            .:||...|.|:|..|.:.:::||...:..||.|.:...||::...:. :|||..:..|..:..|:
Mouse   563 EVEVFYPDFGNIGTVQKSSLRFLKCCYTKLPAQAIPCSLAWVRPAEE-HWTARAILHFQKLCGLK 626

  Fly   514 LLYAKVEAIKNNTAYLVLVDTES------------QGHTV 541
            .|...|:...:....:.|.||.|            :||.:
Mouse   627 PLVGVVDEYIDGILNIFLCDTSSNEDVYFHHVLRTEGHAI 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tej	NP_610950.2	LOTUS_TDRD_OSKAR	7..93	CDD:193586	24/84 (29%)
tej	NP_610950.2	TUDOR	379..488	CDD:278965	32/115 (28%)
Tdrd5	NP_001128213.1	LOTUS_1_TDRD5	4..98	CDD:193599	26/92 (28%)
		LOTUS_2_TDRD5	127..196	CDD:193589	1/68 (1%)
		LOTUS_3_TDRD5	292..365	CDD:193590	18/76 (24%)
		TUDOR	483..602	CDD:278965	34/124 (27%)
		TUDOR	537..583	CDD:119391	15/51 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	857..891
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	912..975
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4955
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006089
OrthoInspector	1	1.000	-	-		oto93994
orthoMCL	1	0.900	-	-		OOG6_108167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5816
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.720