DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tej and Tdrd6

DIOPT Version :9

Sequence 1:	NP_610950.2	Gene:	tej / 36590	FlyBaseID:	FBgn0033921	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001154838.1	Gene:	Tdrd6 / 210510	MGIID:	2679727	Length:	2135	Species:	Mus musculus

Alignment Length:	609	Identity:	118/609 - (19%)
Similarity:	205/609 - (33%)	Gaps:	188/609 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ELSLVKKVVHSLVVSSPGKLTVEQLMRDYRSEEGCTLPYSKLGFKDAESFLRSIPDTVTVTGHG- 69
            ||.|.::|..||..|         |::.|.:..|       .|...|....|:.|.    ..|.
Mouse   193 ELGLARQVPDSLFCS---------LLKRYLTAAG-------QGSSGAPVLPRAAPK----QEHPG 237

  Fly    70 --------QMAWITAVATAKSAHIQKLVRCQKKSKNRGSHKPKYCYASEPSNLVFINESVSKMKN 126
                    |:.....|...:..|..: :.||.:|.::..|:              ::||::::
Mouse   238 LDYFYPQLQLGVTEPVVVTQVCHPHR-IHCQLRSLSQEIHR--------------LSESMAQV-- 285

  Fly   127 RKAPFPTYQVPRNLKLPVSYPNYNRLLYPVHTPHIDQMISTGQQQSTLRTQRPSFPCNANSKSLK 191
                   |:.                  ||.|...|...:|.:::.. ...:|..||
Mouse   286 -------YRA------------------PVGTDDEDSGSATWEEREE-SPDKPGSPC-------- 316

  Fly   192 VNDWSQKDRKQEPSKERNNQKYPKITTENKQEKETEELAQAFENLSVDVAPTDHQEKLKCEIYED 256
                        .|...:.|.|..:..|..:.:...::      |.||..   .:|.:.|.....
Mouse   317 ------------ASCGLDGQWYRALLLETFRPQRCAQV------LHVDYG---RKELVSCSSLRY 360

  Fly   257 NEDEFVRDPFI--------------------YGEVKEKEDEAVVL------------AFDAV--- 286
            ...|:.|.|.:                    .|::|     |::|            :|:.:
Mouse   361 LLPEYFRMPVVTYPCALYGLWDCGRGWSRSQVGDLK-----ALILGQAVNAKIEFYCSFEHMYYV 420

  Fly   287 ---SEDGFDLLSMTTTQQNAVKPLDPPEDCL--HYASSDDGEDENAIPAYAVDHRVLDVDYPRDA 346
               .|||.:|.|....|          ..||  .:..|...|:|.              :...|.
Mouse   421 TLYGEDGINLNSAFGVQ----------SCCLADWFLQSQGIEEEE--------------EEDEDE 461

  Fly   347 VRSAF--TLPARDIESIIELQ--QRIRVQL-------VSLVNPHNFNFWIYNDDFKDYEAQFANM 400
            |.:||  ..||.::|:.:.|.  :.||:::       |..|...: .|||.....|:..::....
Mouse   462 VEAAFQSQSPAEEMEAEVSLPSLRSIRLKMNTFYDAQVEFVKSPS-EFWIRLRKHKNTFSKLTKR 525

  Fly   401 QTFYESSESKNYTMPLFLITTDHLCVVRCTSGWERAKVLGYRSSNNKMTIEVELVDIGDIIRVSQ 465
            ...:.||.||...:.|.....|..||....:|:.||.|....|.    :::|.|||.|:...|..
Mouse   526 MCSFYSSASKLDGVILRPEPDDLCCVKWKENGYYRATVTRLDSK----SVDVFLVDRGNSENVDW 586

  Fly   466 QNVKFLIKPFALLPRQCLAGRLAFITQCKSPNWTAEVVNFFHDMILLRLLYAKVEAIKNNTAYLV 530
            .:|:.|:..|..||...|...||.|... ...|:.|..:||...:|.:.|...| ..|.:..|::
Mouse   587 CDVRMLLPQFRQLPILALKCTLADIWPL-GKTWSQEATSFFKKTVLHKELVVHV-LDKQDHQYVI 649

  Fly   531 LVDTESQGHTVNLNRSLIETGWVR 554
            .:..||:....|:::.:.:.|:.:
Mouse   650 EILDESRMGEENISKVIAQAGFAK 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tej	NP_610950.2	LOTUS_TDRD_OSKAR	7..93	CDD:193586	18/94 (19%)
tej	NP_610950.2	TUDOR	379..488	CDD:278965	29/108 (27%)
Tdrd6	NP_001154838.1	TUDOR	10..133	CDD:278965
		TUDOR	245..379	CDD:278965	30/205 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..315		6/46 (13%)
		TUDOR	313..359	CDD:119391	11/74 (15%)
		TUDOR	489..610	CDD:278965	32/125 (26%)
		TUDOR	547..591	CDD:119391	15/47 (32%)
		TUDOR	773..890	CDD:278965
		TUDOR	826..869	CDD:119391
		TUDOR	987..1106	CDD:278965
		TUDOR	1042..1084	CDD:119391
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1271..1296
		TUDOR	1309..1428	CDD:278965
		TUDOR	1362..1406	CDD:119391
		TUDOR	1519..1641	CDD:278965
		TUDOR	1574..1621	CDD:119391
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1699..1733
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1860..1885
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1930..1987
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900