Protein Alignment tej and TDRKH

DIOPT Version :10

• Sequence 1: NP_610950.2
• Gene: tej / 36590
• FlyBaseID: FBgn0033921
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_006853.2
• Gene: TDRKH / 11022
• HGNCID: 11713
• Length: 561
• Species: Homo sapiens
• Alignment Length: 590
• Identity: 115/590 - (19%)
• Similarity: 211/590 - (35%)
• Gaps: 153/590 - (25%)

  Fly     7 LSLVKKVVHSLVVSSPGKLTVEQLM-RDYRS--EEGCTLPYSKLGFKDAESFLRSIPDTVTVTGH 68
            ||.::|:  :|.:..|...||..:: |.||.  ||..|.    :|..|.|..:| :|...
Human    11 LSTIQKI--ALGLGIPASATVAYILYRRYRESREERLTF----VGEDDIEIEMR-VPQEA----- 63

  Fly    69 GQMAWITAVATAKSAHIQKL-----VRCQKKSKNRGSHKPKYCYASEPSNLVFIN---ESVSKMK 125
                 :..:...:.|:|::|     .|....:::.|..:           ::.|:   ..|.|.|
Human    64 -----VKLIIGRQGANIKQLRKQTGARIDVDTEDVGDER-----------VLLISGFPVQVCKAK 112

  Fly   126 NRKAPFPTYQVPRNLKLPVSYPNYNRLLYPVHTPHIDQMISTGQQQSTLRTQRPSFPCNANSKSL 190
            .......|...|.:.:|.|...:..|::              |:...|:|:     .|.|:.
Human   113 AAIHQILTENTPVSEQLSVPQRSVGRII--------------GRGGETIRS-----ICKASG--- 155

  Fly   191 KVNDWSQKDRKQEPSKERNNQKYPKITTENKQEKETEELAQAFE--NLSVDVAPTDH--QEKLKC 251
                                   .|||.: |:.:.|..|::..:  ....:||...|  .||:
Human   156 -----------------------AKITCD-KESEGTLLLSRLIKISGTQKEVAAAKHLILEKV-- 194

  Fly   252 EIYEDNEDEFVRDPFIY-GEVKEKEDEAVVLAFDAVSEDGF----DLLSMTTTQQNAVKPL--DP 309
                 :|||.:|....: .|.:....:.:.:..:.::|.|.    .|...|::......||  .|
Human   195 -----SEDEELRKRIAHSAETRVPRKQPISVRREDMTEPGGAGEPALWKNTSSSMEPTAPLVTPP 254

  Fly   310 PE---DCLHYAS--------SDDG---EDENAIPAYAVDHRVLDVDYPRDAVRSAFTLPARDIES 360
            |:   |.....|        |||.   .:..|||...:                 |.:|:.|..
Human   255 PKGGGDMAVVVSKEGSWEKPSDDSFQKSEAQAIPEMPM-----------------FEIPSPDFS- 301

  Fly   361 IIELQQRIRVQLVSLVNPHNFNFWIYNDDFKDYEAQFANMQTFYESSESKNYTMPLFLITTDHLC 425
             ....:.:.|.:.:..:|::|...|........:.....|...||:|..::.|:.:    .|.:.
Human   302 -FHADEYLEVYVSASEHPNHFWIQIVGSRSLQLDKLVNEMTQHYENSVPEDLTVHV----GDIVA 361

  Fly   426 VVRCTSG-WERAKVLGYRSSNNKMTIEVELVDIGDIIRVSQQNVKFLIKPFALLPRQCLAGRLAF 489
            ....|:| |.||:|||...:.|   :::..||.||......::::.|...|..||.|.:...||.
Human   362 APLPTNGSWYRARVLGTLENGN---LDLYFVDFGDNGDCPLKDLRALRSDFLSLPFQAIECSLAR 423

  Fly   490 ITQCKSPNWTAEVVNFFHDMI-------LLRLLYAKVEAIKNNTAYLVLVDTESQGHTVNLNRSL 547
            |.. ....|..|.::.|..:.       |:..:.:.|:...:....:.|.|| |.|..:::...|
Human   424 IAP-SGDQWEEEALDEFDRLTHCADWKPLVAKISSYVQTGISTWPKIYLYDT-SNGKKLDIGLEL 486

  Fly   548 IETGW 552
            :..|:
Human   487 VHKGY 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tej	NP_610950.2	LOTUS_TDRD_OSKAR	7..93	CDD:193586	22/93 (24%)
		TUDOR	379..488	CDD:425754	26/109 (24%)
TDRKH	NP_006853.2	KH-I_TDRKH_rpt1	49..119	CDD:411856	14/91 (15%)
		KH-I_TDRKH_rpt2	124..205	CDD:411857	24/133 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..262		9/42 (21%)
		Tudor_TDRD2	328..420	CDD:410483	24/98 (24%)