DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tej and tdrd7b

DIOPT Version :9

Sequence 1:	NP_610950.2	Gene:	tej / 36590	FlyBaseID:	FBgn0033921	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001340858.1	Gene:	tdrd7b / 100004703	ZFINID:	ZDB-GENE-150109-14	Length:	1085	Species:	Danio rerio

Alignment Length:	846	Identity:	152/846 - (17%)
Similarity:	261/846 - (30%)	Gaps:	333/846 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LVKKVVHSLVVSSPGKLTVEQLMRDYRSEEGCTLPYSKLGFKDAESFLRSIPDTV---------- 63
            ||||:|.:::.||...|::..|..:|:...|..:||.:||:...::.|.|:|..|
Zfish     6 LVKKMVRAVLQSSKSGLSLSDLQVEYKDLTGELIPYKQLGYVTLDALLHSMPSIVKLDKGQSGEV 70

  Fly    64 ---TVTGHGQMAWITAVA----TAKSAHIQKLVRCQKKSK------------------------- 96
               ..||: :||.||.:|    |||.....::|.||.:.|
Zfish    71 MCHATTGN-EMAHITKLAARQRTAKKTGRPQVVNCQMRVKPAAPLVLNAKPRTSLRQPDHRGRLG 134

  Fly    97 --------------------------------NRGSHKP------------------KYCYA--- 108
                                            |..|.||                  |..:|
Zfish   135 RGGGRGHGDTRTGCMRDPQLDGKGGRPHNTPPNTPSRKPSLPSERPEKRMTLPSRFQKEVHAHIL 199

  Fly   109 ------SEPSNLVFINESVSKMKNR---KAPFPTYQVPRNL--------------KLPVSYPNYN 150
                  :.||||   ||:.:..|.|   .||:....|...|              |||..|..:.
Zfish   200 RNPQHINVPSNL---NENTTPPKPRLPHSAPYSPKLVQSRLQEVLNKHSNGLWVSKLPQLYREHY 261

  Fly   151 RLLYP----------VHTPHIDQMISTGQQQSTLRTQRPSFPCNANSK--SLKVNDWS----QKD 199
            :...|          .|...:::..|:..|:..|      :|....|:  ....:|.|    :|.
Zfish   262 KQDLPSEALKELENWTHICTVEKPCSSKPQELLL------YPAKETSQITPTPTHDRSPSHHKKP 320

  Fly   200 RKQEPS--KERNNQKYPKITTENKQEKETEELAQAFENLSVDVAPTDHQEKLKCEIYEDNEDEFV 262
            :.|.||  .:.|..:.||..:.:.::|..|.|.:....|.....|..:|:..||::     .|||
Zfish   321 QTQRPSLTAKSNTPESPKALSPDLKQKLGELLLKYSSGLWAHALPKLYQDTYKCKL-----PEFV 380

  Fly   263 RDPF--------IYGEVKEKEDEAVVLAFDAVSED---------GFDLLSMTTTQQNAVKPLDPP 310
            .|..        |...|.:....|::.|  .|.||         |.::..........|.||..|
Zfish   381 LDQLTLLSDICTIDYPVPDNPKRAILYA--KVVEDENRNQSGLAGQEMKLERRLSSQTVPPLVIP 443

  Fly   311 EDCLHYAS--SDDGEDENAI------PAYAVDHRVLDVD----YPRDAVRSAFTLP--------- 354
            .  :.|.|  ..|..|.|.:      ..|:.....|:.:    |.:|..:.|...|
Zfish   444 R--VEYPSVLVVDASDTNCVILRYIGEGYSKAQEKLEDEMREFYRQDNTKMALRSPSPGQLTAVG 506

  Fly   355 ARDIESIIELQ------QRIRV--------QLVSLVNPHNFNFWIYNDDFKDYEAQFANMQTF-- 403
            |.:.:.||..|      .:::|        :::|:......|...|...|:..:.:.|.:::|
Zfish   507 AEEEDDIIRAQVCEVMADKVKVYYVDHGFSEVISIRKLFELNEKFYRLPFQATKCKLAGLESFSQ 571

  Fly   404 --------------------------------YESS---------------ESKNYTMPLFL--- 418
                                            |::|               :.::...||.:
Zfish   572 EQAVLKKLESIATGKILLAEILEREDMPLVVLYDTSQDDDVNINAACMKALQDRSLESPLKVNSA 636

  Fly   419 -----------------------------------------ITTDHL---------CVVRCTSGW 433
                                                     :|::.|         |:.|....|
Zfish   637 YMNVSVTSVCSDGTIYCQVPSRGLTKLNEILEKTENYFHSQVTSESLVSRPFCGKNCLARYKGKW 701

  Fly   434 ERAKVLGYRSSNNKMTIEVELVDIGDIIRVSQQNVKF------LIKPFALLPRQ----CLAGRLA 488
            .|.::.....|.   .:::..||:|  ::.|.:.::.      |::.....|.|    ||||...
Zfish   702 SRVEITNLHGSR---VLDILFVDVG--VQASVEVIELREIPPPLLRDLISTPAQALKCCLAGLPV 761

  Fly   489 FITQCKSPNWTAEVVNFFHDMIL----LRLLYAKVEAIKNNTAYLVLVDTESQGHTVNLNRSLIE 549
            .:..     ||.:.|.:..|.:|    ..|..|||:..|......:.........:.:||:.|.:
Zfish   762 SVGL-----WTPDAVQWLRDTVLHISDCSLKIAKVDETKRLAHVYLFTSKNFHDTSCSLNQQLAD 821

  Fly   550 T 550
            :
Zfish   822 S 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tej	NP_610950.2	LOTUS_TDRD_OSKAR	7..93	CDD:193586	31/100 (31%)
tej	NP_610950.2	TUDOR	379..488	CDD:278965	27/220 (12%)
tdrd7b	NP_001340858.1	LOTUS_1_TDRD7	4..91	CDD:193600	26/85 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..183		4/70 (6%)
		Retinal	<160..342	CDD:330657	38/190 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..228		9/30 (30%)
		LabA_like_C	232..297	CDD:326367	11/70 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..341		11/43 (26%)
		LOTUS_3_TDRD7	341..408	CDD:193588	15/71 (21%)
		TUDOR	442..565	CDD:306940	21/124 (17%)
		TUDOR	636..758	CDD:306940	16/126 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	843..888
		TUDOR	897..1013	CDD:306940
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12201
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900