DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ih and KCNH7

DIOPT Version :9

Sequence 1:NP_001033948.1 Gene:Ih / 36589 FlyBaseID:FBgn0263397 Length:1327 Species:Drosophila melanogaster
Sequence 2:XP_011510411.1 Gene:KCNH7 / 90134 HGNCID:18863 Length:1204 Species:Homo sapiens


Alignment Length:883 Identity:205/883 - (23%)
Similarity:347/883 - (39%) Gaps:228/883 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   511 DYTHHSSSNGSQQEGSSEANEGHEPVGESTITVA---------SAGVSYPHPYSYPYHYAHHASS 566
            |.:.||..:.:.:...|...|...| .|:..|.|         ...:|.|..:|.|    .....
Human   186 DSSKHSDDSVAMKHFKSPTKESCSP-SEADDTKALIQPSKCSPLVNISGPLDHSSP----KRQWD 245

  Fly   567 ATAPANLKASLQL-HSFGSHHPCPYPARPTSTSCTNSF--NRRHIRRHKGKLGDRLLSGDSEESV 628
            ...|..|::|.|| ||......|.. .|.:|......|  :.::|.|      ||..|.|:..:|
Human   246 RLYPDMLQSSSQLSHSRSRESLCSI-RRASSVHDIEGFGVHPKNIFR------DRHASEDNGRNV 303

  Fly   629 RCSYCSVLNVNDNDLRISFENTCTDSLVTAFDDEALLICDQGTEMVHFDDVSLYGTPKEEPMPNI 693
            :.|...:.....|.::.|...:.:||                       :::.|.|..:.|    
Human   304 KVSRSWMAGGPFNHIKSSLLGSTSDS-----------------------NLNKYSTINKIP---- 341

  Fly   694 PIVSEKVSANF--LKSQLQSWFQPTDNR--LAMKLFGSRKALVKERIRQKTS------------- 741
                 :::.||  :|::.::...|:.::  :|.|: ..|...|.|::.|..|             
Human   342 -----QLTLNFSEVKTEKKNSSPPSSDKTIIAPKV-KDRTHNVTEKVTQVLSLGADVLPEYKLQT 400

  Fly   742 ---GHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISF-FND--DLSTRWIAFNC--------L 792
               ..:.|...|.|:..||..:|||::...|..|.:.:| .||  :...|...::|        :
Human   401 PRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLI 465

  Fly   793 SDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQIMKL 857
            .|.:|:|||::||||..:.|:  |:|:.||..||.||.:.||.:|::::||.|  .|||.     
Human   466 VDIMFIIDILINFRTTYVNQN--EEVVSDPAKIAIHYFKGWFLIDMVAAIPFD--LLIFG----- 521

  Fly   858 QDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNR 922
             ..||....|     :.:|:.|:||.|||:.|  :|.||......|.:|                
Human   522 -SGSDETTTL-----IGLLKTARLLRLVRVAR--KLDRYSEYGAAVLML---------------- 562

  Fly   923 KDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSINELQE 987
                                       |:|:..||.||..|:              |.:|..::.
Human   563 ---------------------------LMCIFALIAHWLACI--------------WYAIGNVER 586

  Fly   988 SY------WL-----------------------EQYSWALFKAMSHMLCIGYGRFPPQSLTDMWL 1023
            .|      ||                       ::|..||:...|.:..:|:|...|.:.::...
Human   587 PYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIF 651

  Fly  1024 TMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRY 1088
            ::..|:.|:..||...|:.:.:||.|.|...:|..::.:|:|::.:.::|..:|||:.|||:|.:
Human   652 SICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAW 716

  Fly  1089 ---QGKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDI 1150
               .|  .|..::|....|.|:.|:..:..::|:.:...|..|....:..:..|.|.....|||.
Human   717 TYTNG--IDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDT 779

  Fly  1151 IIKEGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYFGEICLL--TNARRVASVRAETYCNLFS 1213
            ::..|.:.|.:||:..|.::| :.:..|...|.....|||:..|  ...:..|.|||.|||:|..
Human   780 LVHCGDVLTALYFLSRGSIEI-LKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHK 843

  Fly  1214 LSVDHFNCVLDQYPLMRKTMETVAAERLNKIGKNPNIMHQ--KDEQLSNPESNTITAVVNALAAE 1276
            :..:....|||.||       ..:...|..:....|:.|:  |.:.|.:...|.         :|
Human   844 IQREDLLEVLDMYP-------EFSDHFLTNLELTFNLRHESAKADLLRSQSMND---------SE 892

  Fly  1277 ADDCKDDDMDL-------KENLLHGSESSIAEPVQTIR 1307
            .|:||.....|       |||..:..|.|    ..|||
Human   893 GDNCKLRRRKLSFESEGEKENSTNDPEDS----ADTIR 926

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IhNP_001033948.1 Ion_trans_N 709..751 CDD:285597 9/59 (15%)
Ion_trans 771..1054 CDD:278921 77/322 (24%)
Crp 1118..>1241 CDD:223736 33/124 (27%)
CAP_ED 1124..1233 CDD:237999 32/110 (29%)
KCNH7XP_011510411.1 PAS_9 29..134 CDD:290162
PAS 41..130 CDD:238075
Ion_trans 456..679 CDD:278921 71/296 (24%)
Ion_trans_2 <622..676 CDD:285168 13/53 (25%)
Crp 747..>884 CDD:223736 37/144 (26%)
CAP_ED 753..864 CDD:237999 32/118 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0498
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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