DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ih and Cnga4

DIOPT Version :10

Sequence 1:NP_001033948.1 Gene:Ih / 36589 FlyBaseID:FBgn0263397 Length:1327 Species:Drosophila melanogaster
Sequence 2:NP_445948.2 Gene:Cnga4 / 85258 RGDID:619844 Length:575 Species:Rattus norvegicus


Alignment Length:622 Identity:148/622 - (23%)
Similarity:269/622 - (43%) Gaps:115/622 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   744 W--VIHPCSSFRFYWDLCMLLLLVANLIILPVAISFFNDDLS----TRWIAFNCLSDTIFLIDIV 802
            |  |:.|...:.::|...|:..::.||||:.....|  .||.    ..|...:..||.::|:||.
  Rat    23 WLPVLDPSGDYYYWWLNTMVFPIMYNLIIVVCRACF--PDLQHSYLVAWFVLDYTSDLLYLLDIG 85

  Fly   803 VNFRTGIMQQDNAEQVILDPKLIAKHYLRTW-FFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQI 866
            |.|.||.::|.   .:::|..:||..|:||| |.|||.|.:|.|..:                  
  Rat    86 VRFHTGFLEQG---ILVVDKGMIASRYVRTWSFLLDLASLVPTDAAY------------------ 129

  Fly   867 LHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKS 931
            :..|..:..|||.      |.||:.||.....:.|......|.                      
  Rat   130 VQLGPHIPTLRLN------RFLRVPRLFEAFDRTETRTAYPNA---------------------- 166

  Fly   932 NLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSINELQESY--WLEQY 994
                         .||..|:..:.::.||:.||.|.:....||..::||..:..|..:  ...||
  Rat   167 -------------FRIAKLMLYIFVVIHWNSCLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQY 218

  Fly   995 SWALFKAMSHMLCIGYGRFPPQSLTDMWLTML-SMISGATCYALFLGHATNLIQSLDSSRRQYRE 1058
            .::.:  .|.::....|..|.....:.:|.|: ..:.....:|..:|..:::|.:::::...:..
  Rat   219 LYSFY--FSTLILTTVGDTPLPDREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYP 281

  Fly  1059 KVKQVEEYMAYRKLPRDMRQRITEYFEH-RYQGKFFDEELILGELSEKLREDVINYNCRSLVASV 1122
            ....|::||..:.:.:.:.:|:.::::| :...|..:|..||..|.|:||.:|......|.::.|
  Rat   282 DHALVKKYMKLQHVNKRLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRV 346

  Fly  1123 PFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATS-LSDGS 1186
            ..|.|.:::.:.::|.||:.:.:.||:.:.::|.||.:||.|:||.:.:|..:|....: |..|.
  Rat   347 QIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGREMYIIREGQLAVVADDGVTQYAVLGAGL 411

  Fly  1187 YFGEICL------LTNARRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAE---RLN 1242
            |||||.:      ::..||.|::::..|.:||.||.:....||.:||..:..||....|   ::|
  Rat   412 YFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQAVMEEKGREILLKMN 476

  Fly  1243 KIGKN---PNIMHQK---------DEQLSNPESN--------TITAVVNALAAEADDCKDDDMDL 1287
            |:..|   ..|..|:         |:||.:.::.        ..:|:..|...|..:.:..:..:
  Rat   477 KLDVNAEAAEIALQEATESRLKGLDQQLDDLQTKFARLLAELESSALKIAYRIERLEWQTREWPM 541

  Fly  1288 KENLLHGSESSIAEPVQTIREGLPRPRSGEFRALFEG 1324
            .|::  |.....|||      |....:.||.:|..||
  Rat   542 PEDM--GEADDEAEP------GEGTSKDGEGKAGQEG 570

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IhNP_001033948.1 Ion_trans_N 709..751 CDD:400630 3/8 (38%)
PLN03192 741..>1214 CDD:215625 117/487 (24%)
Cnga4NP_445948.2 Ion_trans 34..273 CDD:459842 68/304 (22%)
Ion conduction pathway. /evidence=ECO:0000250|UniProtKB:P29973 164..272 24/144 (17%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P29973 231..234 0/2 (0%)
C-linker. /evidence=ECO:0000250|UniProtKB:P29973 274..350 16/75 (21%)
IQ-type. /evidence=ECO:0000250 292..302 0/9 (0%)
CAP_ED 348..464 CDD:237999 36/115 (31%)
Cyclic nucleotide-binding domain. /evidence=ECO:0000250|UniProtKB:P29973 354..474 37/119 (31%)
CLZ 464..534 CDD:465160 14/69 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..575 11/42 (26%)

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