DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ih and Hcn1

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_445827.2	Gene:	Hcn1 / 84390	RGDID:	620688	Length:	902	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	315/573 - (54%)
Similarity:	424/573 - (73%)	Gaps:	45/573 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   704 FLKSQLQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSSFRFYWDLCMLLLLVANL 768
            |::.|..|..||..|:.::::|||:||:.||:.|.||:|.|:|||.|.|||||||.||:::|.||
  Rat    82 FMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNL 146

  Fly   769 IILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTW 833
            :|:||.|:||.:..:|.||.||..|||:||:|:::|||||.:.:|::| :|||||:|..:||::|
  Rat   147 VIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSE-IILDPKVIKMNYLKSW 210

  Fly   834 FFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVS 898
            |.:|.|||||:||||||..:.|      || ::....|||||:|..|:|||:||||||||:||:.
  Rat   211 FVVDFISSIPVDYIFLIVEKGM------DS-EVYKTARALRIVRFTKILSLLRLLRLSRLIRYIH 268

  Fly   899 QWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGC 963
            ||||::.:.                              .::||..:||||||.||||:.||.||
  Rat   269 QWEEIFHMT------------------------------YDLASAVVRIFNLIGMMLLLCHWDGC 303

  Fly   964 LQFLVPMLQGFPSNSWVSINELQESYWLEQYSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSM 1028
            ||||||:||.||.:.|||:||:....|.:|||:|||||||||||||||...|.|::|:|:|||||
  Rat   304 LQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSM 368

  Fly  1029 ISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRYQGKFF 1093
            |.||||||:|:||||.||||||||||||:||.||||:||::.|||.||||:|.:|:|||||||.|
  Rat   369 IVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIF 433

  Fly  1094 DEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIG 1158
            |||.||.||::.|||:::|:|||.|||::|.|||||.|||:.:::||::|||||||.||:||.:|
  Rat   434 DEENILSELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVG 498

  Fly  1159 TKMYFIQEGVVDIVMANGEVATSLSDGSYFGEICLLTNARRVASVRAETYCNLFSLSVDHFNCVL 1223
            .||||||.||..::..:.: ...|:||||||||||||..||.|||||:|||.|:|||||:||.||
  Rat   499 KKMYFIQHGVAGVITKSSK-EMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVL 562

  Fly  1224 DQYPLMRKTMETVAAERLNKIGKNPNIMHQKDEQ------LSNPESNTITAVV 1270
            ::||:||:..||||.:||::|||..:|:.||.::      .:|.|:..:..:|
  Rat   563 EEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIV 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	19/41 (46%)
		Ion_trans	771..1054	CDD:278921	151/282 (54%)
		Crp	1118..>1241	CDD:223736	75/122 (61%)
		CAP_ED	1124..1233	CDD:237999	67/108 (62%)
Hcn1	NP_445827.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..75
		PLN03192	122..>609	CDD:215625	297/525 (57%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:O60741	347..351		3/3 (100%)
		CAP_ED	464..572	CDD:237999	67/108 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	634..681
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	713..732
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	858..902
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	178	1.000	Domainoid score	I3458
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000897
OrthoInspector	1	1.000	-	-		otm46198
orthoMCL	1	0.900	-	-		OOG6_101339
Panther	1	1.100	-	-	O	PTHR45689
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X717
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.910