Protein Alignment Ih and Cngb1

DIOPT Version :10

• Sequence 1: NP_001033948.1
• Gene: Ih / 36589
• FlyBaseID: FBgn0263397
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: NP_113997.2
• Gene: Cngb1 / 83686
• RGDID: 621809
• Length: 1338
• Species: Rattus norvegicus
• Alignment Length: 1203
• Identity: 229/1203 - (19%)
• Similarity: 406/1203 - (33%)
• Gaps: 352/1203 - (29%)

  Fly   139 PVSCGTQSVSSTGGQSALY-------DACHEYSRSLSAAAAEGAASLLKSH----YSDQQLAQTE 192
            |.:|..|::|....:.|.:       |:|.|.::.      |..|||.::.    |.|:..|..|
  Rat   294 PGTCDVQTISILPVEQAEHDLVLEDVDSCWEDTQQ------EDGASLQETELAPIYEDESEAMVE 352

  Fly   193 -PDPEPDPERDRDRDRDRDRDRERERRHLTNLNLNLSSEYDYSGSDKQQLVNETYIFKCIANSPS 256
             |...|..:.:::.:.:...:.|.|:.         ..|......:|::
  Rat   353 MPRELPQIQEEQEEENEEKEEEEEEKE---------EKEEKEEEEEKEE---------------- 392

  Fly   257 FLRTNKIKEQSKKLRNLSLKTRTAKKKGQIISKSNAVSDNSLHPG------------DKYLNLYL 309
               ..|.:|:.||.:....|.:..::||:...|... .:.....|            ::......
  Rat   393 ---EEKREEEKKKEKEEEKKEKEEEEKGEEEEKEEK-EEKEEEEGKEEKEEKEEKEEEEKEEKEE 453

  Fly   310 VEKKHSLQPQVASTSSSINTTHPQASSAPASSSSTCTKAP------QLPALSAVAARQQQLLLNG 368
            .||:...:.:.............:....|.....:|....      ||.......|..|:|....
  Rat   454 EEKEEKEEEEKEEKEEEEEEEEEEEEEEPIVLLDSCLVVQADVDQCQLERAQPETASIQELPEEE 518

  Fly   369 SLKGKGQSQSQGQSRQTLPGHRASVRSESGSGSSHTIPATGKSPPVPHSLAAKISSSASGSKNCN 433
            ..|.:.:.:.:.:..:.........:.|.|..::.|:|||.:.|.:
  Rat   519 EEKEEEKKEEEEEKEEEEEKEEEEEKEEEGEATNSTVPATKEHPEL------------------- 564

  Fly   434 LLSASSNSCHKLNAHAQGSGAGSGSGSGSGSGPPGHSHYAAASPKSSVSSNGHLNKYCLTDLTRR 498
                          ..:.:.|.:|......:.||     ....|.|...|:
  Rat   565 --------------QVEDTDAEAGPLIPEETIPP-----PERPPVSPAKSD-------------- 596

  Fly   499 KAEFNRQLSAPTDYTHHSS--SNGSQQEGSSEANEGHEPVGESTITVASAGVSYPHPYSYPYHYA 561
                  .|:.|...||...  |...:.|.....:....||           |::..|
  Rat   597 ------TLAVPGAATHRKKLPSQDDEAEELKALSPAESPV-----------VAWSDP-------- 636

  Fly   562 HHASSATAPANLKASLQLHSFGSHHPCPYPARPTSTSCTNS--FNRR------HIRRHKGKLGDR 618
                  |.|......               .|..||:..||  .|.|      ..:....|:.::
  Rat   637 ------TTPQEADGE---------------DRAASTASQNSAIINDRLQELVKMFKERTEKVKEK 680

  Fly   619 LLSGD---SEESVRCSYCSVLNVNDNDLRISFENTCTDSLVTAFDDEALLICDQGTEMVHFDDV- 679
            |:..|   .|||.:.|..               ....||.......||     :..|..|:.|:
  Rat   681 LIDPDVTSDEESPKPSPA---------------KKAPDSAPAQKPAEA-----EAAEEEHYCDML 725

  Fly   680 ---------SLYGTPKE-EPMPNIPIVSEKVSANFLKSQLQSWFQPTDNRLAMKLFGSRKALVKE 734
                     .:|..|:. :|:.|:..:
  Rat   726 CCKFKRRPWKMYQFPQSIDPLTNLMYI-------------------------------------- 752

  Fly   735 RIRQKTSGHWVIHPCSSFRFYWDLCMLLLLVANLIILPV--AISFFNDDLSTRWIAFNCLSDTIF 797
                                .|...::|....|..::||  |..:...|....|:..:.|.|.|:
  Rat   753 --------------------LWLFFVVLAWNWNCWLIPVRWAFPYQRADNIHLWLLMDYLCDFIY 797

  Fly   798 LIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTW-FFLDLISSIPLDYIFLIFNQIMKLQDFS 861
            |:||.| |:.. :|......:|.|.|.:..:||::. |.:||:..:|||:::|
  Rat   798 LLDITV-FQMR-LQFVKGGDIITDKKEMRNNYLKSQRFKMDLLCLLPLDFLYL------------ 848

  Fly   862 DSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRKDKD 926
                               .|.:..||||.|.::|::.:|
  Rat   849 -------------------KLGVNPLLRLPRCLKYMAFFE------------------------- 869

  Fly   927 GLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSINELQESYWL 991
               .:|.:...|:.|.|: |:......:|...|.:.||.:.....||..|..|| .:.:..|| :
  Rat   870 ---FNNRLEAILSKAYVY-RVIRTTAYLLYSLHLNSCLYYWASAFQGIGSTHWV-YDGVGNSY-I 928

  Fly   992 EQYSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQY 1056
            ..|.|    |:..::.|| |...||:|.::...:|:..:|...:::.:|...:::.:..:.:..|
  Rat   929 RCYYW----AVKTLITIG-GLPDPQTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYY 988

  Fly  1057 REKVKQVEEYMAYRKLPRDMRQRITEYFEHRYQGK-FFDEELILGELSEKLREDV---INYNCRS 1117
            |..:....:||.:.|:||.::.|:..::|:.:..: ..||..::.:|.:|:|.|:   :|||
  Rat   989 RSCMDSTVKYMNFYKIPRSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYN--- 1050

  Fly  1118 LVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMA-NGE-VAT 1180
            :|:.|..|...|...:.|::.:|:..|:.|.|.:.|:|.||.:||.||.|.|.::.. :|: |..
  Rat  1051 IVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKAVLV 1115

  Fly  1181 SLSDGSYFGEICLLT---NARRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAERLN 1242
            :|..||.||||.||.   ..||.|:|.|..:.|||.|.....|.:|..||..:|.:...|...|.
  Rat  1116 TLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLR 1180

  Fly  1243 KIGKNPNIMHQKDEQLSNPESNTITAVVNALAA 1275
               .|.....:|...:..|.:.|......||||
  Rat  1181 ---NNNKPKEEKSVLILPPRAGTPKLFNAALAA 1210

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:400630	0/41 (0%)
		PLN03192	741..>1214	CDD:215625	121/484 (25%)
Cngb1	NP_113997.2	PLN03192	743..>1129	CDD:215625	113/515 (22%)
		CAP_ED	1057..1166	CDD:237999	40/108 (37%)