DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ih and SPIK

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_180131.3	Gene:	SPIK / 817099	AraportID:	AT2G25600	Length:	888	Species:	Arabidopsis thaliana

Alignment Length:	566	Identity:	113/566 - (19%)
Similarity:	223/566 - (39%)	Gaps:	106/566 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   756 WDLCMLLLLVANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVIL 820
            |:..::.|::......|....|.........|..|.::. .|.:|||:.|....:  |....:::
plant    83 WETFLVFLVLYTAWASPFEFGFLQKPRPPLSILDNIVNG-FFAVDIVLTFFVAFL--DKVTYLLV 144

  Fly   821 -DPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQIM--KLQDFSDSFQILHAGRALRILRLAKLL 882
             |||.||..|..||...|::|:.|.:    ||..::  .:|.:.                   :.
plant   145 DDPKRIAWRYASTWLIFDVVSTFPYE----IFGSLLHESIQGYG-------------------IF 186

  Fly   883 SLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRI 947
            |::||.||.|:....::.|:            ||:                      .:..::|.
plant   187 SMLRLWRLRRVSNCFARLEK------------DRK----------------------YSYFWVRC 217

  Fly   948 FNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSINELQESYWLE-----QYSWALFKAMSHMLC 1007
            ..|:.:.|.:.|...|..:.:......||.::::   |.:..|.|     :|:.|::.:::....
plant   218 SKLLLVTLFVIHCGACFLYSIAAHYPDPSKTFMA---LTDENWKESPIAVRYNTAMYWSITTFST 279

  Fly  1008 IGYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKL 1072
            .|||.....:..:|...:..|:......|..:|:.|||:..:....|::|:.::....:.....|
plant   280 TGYGDIHGVNSREMTFILFYMVFNLGLSAYIIGNMTNLVVHVTGRTRKFRDTIQAASGFGQRNNL 344

  Fly  1073 PRDMRQRITEYFEHRYQ--GKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSD 1135
            |..::.::..:...||:  .:...::.|:..|.:.:|..:.:|....:|..:..|....::.:..
plant   345 PVRLQDQMVAHLCLRYRTDSEGLQQQEIIDSLPKAIRSSISHYLFYEVVDKIYLFHGISNDLLFQ 409

  Fly  1136 VVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIV-MANG--EVATSLSDGSYFGEICLLTNA 1197
            :||::|.|.|.|.:.:|.:....|..|.:..|.|||: ..||  :|.:....|..|||:.:|...
plant   410 LVTEMKAEYFPPKEDVILQNEAPTDFYILVTGAVDIIARVNGVEQVVSEAQRGHVFGEVGVLCYR 474

  Fly  1198 RRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAERLNKIGKNPNIMHQKDEQLSNPE 1262
            .::.:||.:....|..|:    ..||         :..|.|    .:|....||:...:.|.:.|
plant   475 PQLFTVRTKRLSQLLRLN----RTVL---------LNLVQA----NVGDGAIIMNNLLQHLKDSE 522

  Fly  1263 SNTITAVV----NALAAEADD---------CKDDDMDLKENLLHGS 1295
            ...:..|:    :.||....|         .:.||:.|.:.|..||
plant   523 DPVMKGVLADTEHMLAQGKMDLPLSLCFAAARGDDLLLHQLLRRGS 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597
		Ion_trans	771..1054	CDD:278921	55/290 (19%)
		Crp	1118..>1241	CDD:223736	31/125 (25%)
		CAP_ED	1124..1233	CDD:237999	28/111 (25%)
SPIK	NP_180131.3	PLN03192	38..888	CDD:215625	113/566 (20%)
		ANK repeat	548..574	CDD:293786	6/21 (29%)
		ANK repeat	576..607	CDD:293786
		ANK repeat	609..671	CDD:293786
		ANK repeat	673..704	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm987
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820