DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ih and KCNH6

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_110406.1	Gene:	KCNH6 / 81033	HGNCID:	18862	Length:	994	Species:	Homo sapiens

Alignment Length:	735	Identity:	171/735 - (23%)
Similarity:	285/735 - (38%)	Gaps:	197/735 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   588 CPYPARPTSTSCTNSFNRRHIRRHKGKLG------DRLLSGDSEESVRCSYCSVLNVNDNDLRIS 646
            |.:...|.:.|...|      |..:..||      |.|.......|.||....|...|::...|.
Human    66 CDFLTGPNTPSSAVS------RLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVIM 124

  Fly   647 FENTCTDSLVTAFDDEALLI--CDQ-------------GTEMVHFDDVSLYGTP----------K 686
            |        :..|:|.|.|:  |..             |:|..|       |.|          |
Human   125 F--------ILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSH-------GRPGGPGPGTGRGK 174

  Fly   687 EEPMPNIPIVSEKVSANFLKSQLQSWFQPTDNRLAMKLFGSRKAL-----VKERIRQKTS----- 741
            ...:..||    :.:.||::..|:.  ..:.:...:::....|.:     |.|::.|..|
Human   175 YRTISQIP----QFTLNFVEFNLEK--HRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADV 233

  Fly   742 -----------GHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISFF--NDDLSTRW-IAFNC- 791
                       ..|.|...|.|:..||..:|||::...:..|.:.:|.  :.|.|.|. .::.|
Human   234 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCS 298

  Fly   792 -------LSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFL 849
                   :.|.:|::|||:||||..:..:  ::|:..|:.||.||.:.||.:|::::||.|  .|
Human   299 PLTVVDLIVDIMFVVDIVINFRTTYVNTN--DEVVSHPRRIAVHYFKGWFLIDMVAAIPFD--LL 359

  Fly   850 IFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSA 914
            ||      :..||....|     :.:|:.|:||.|||:.|  :|.||......|
Human   360 IF------RTGSDETTTL-----IGLLKTARLLRLVRVAR--KLDRYSEYGAAV----------- 400

  Fly   915 DRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSW 979
                                            :|.|:|...||.||..|:              |
Human   401 --------------------------------LFLLMCTFALIAHWLACI--------------W 419

  Fly   980 VSINELQESY------WL-----------------------EQYSWALFKAMSHMLCIGYGRFPP 1015
            .:|..::..|      ||                       ::|..||:...|.:..:|:|...|
Human   420 YAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSP 484

  Fly  1016 QSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRI 1080
            .:.::...::..|:.|:..||...|:.:.:||.|.|...:|..::.:|:|::.:.::|..:|||:
Human   485 NTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRL 549

  Fly  1081 TEYFEHRYQ-GKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEV 1144
            .|||:|.:. ....|...:|....|.|:.|:..:..|:|:...|.|:.|....:..:..|.|...
Human   550 EEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTH 614

  Fly  1145 FQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYFGEICLL--TNARRVASVRAET 1207
            ..|||.::..|.:.:.:|||..|.::| :.:..|...|.....|||...|  ...:..|.|||.|
Human   615 APPGDTLVHLGDVLSTLYFISRGSIEI-LRDDVVVAILGKNDIFGEPVSLHAQPGKSSADVRALT 678

  Fly  1208 YCNLFSLSVDHFNCVLDQYP 1227
            ||:|..:.......|||.||
Human   679 YCDLHKIQRADLLEVLDMYP 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	8/62 (13%)
		Ion_trans	771..1054	CDD:278921	74/322 (23%)
		Crp	1118..>1241	CDD:223736	34/112 (30%)
		CAP_ED	1124..1233	CDD:237999	32/106 (30%)
KCNH6	NP_110406.1	PAS_9	29..132	CDD:290162	17/79 (22%)
		PAS	41..132	CDD:238075	17/79 (22%)
		Ion_trans	296..520	CDD:278921	68/297 (23%)
		Ion_trans_2	<463..517	CDD:285168	13/53 (25%)
		Selectivity filter. /evidence=ECO:0000250	476..481		1/4 (25%)
		Crp	588..>704	CDD:223736	34/112 (30%)
		CAP_ED	594..705	CDD:237999	32/106 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	720..790
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	880..946
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810