DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ih and HCN2

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_001185.3	Gene:	HCN2 / 610	HGNCID:	4846	Length:	889	Species:	Homo sapiens

Alignment Length:	644	Identity:	341/644 - (52%)
Similarity:	437/644 - (67%)	Gaps:	76/644 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   685 PKEEPMPNIPIVSEKVSANFLKSQLQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPC 749
            |..||..:        .|:|::.|..:..||..|:.::::|||:||:.:|:.|.|::|.|:|||.
Human   151 PAGEPRGS--------QASFMQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPY 207

  Fly   750 SSFRFYWDLCMLLLLVANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDN 814
            |.||||||..|||.:|.||||:||.|:||.|:.:..||.||.:|||.||:|:|:||||||:.:||
Human   208 SDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDN 272

  Fly   815 AEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLA 879
            .| :||||:.|.|.||||||.:|.:||||:||||||      ::...|| ::....|||||:|..
Human   273 TE-IILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLI------VEKGIDS-EVYKTARALRIVRFT 329

  Fly   880 KLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVF 944
            |:|||:||||||||:||:.||||::.:.                              .::||..
Human   330 KILSLLRLLRLSRLIRYIHQWEEIFHMT------------------------------YDLASAV 364

  Fly   945 MRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSINELQESYWLEQYSWALFKAMSHMLCIG 1009
            |||.|||.||||:.||.|||||||||||.||.|.|||||.:....|.|.||:|||||||||||||
Human   365 MRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSELYSFALFKAMSHMLCIG 429

  Fly  1010 YGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPR 1074
            |||..|:|:||:||||||||.||||||:|:||||.||||||||||||:||.||||:||::.|||.
Human   430 YGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPA 494

  Fly  1075 DMRQRITEYFEHRYQGKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTK 1139
            |.||:|.:|:|||||||.|||:.|||||:..|||:::|:|||.||||:|.|||||.|||:.::||
Human   495 DFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTK 559

  Fly  1140 LKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYFGEICLLTNARRVASVR 1204
            ||:|||||||.||:|||||.||||||.|||. |:..|.....||||||||||||||..||.||||
Human   560 LKFEVFQPGDYIIREGTIGKKMYFIQHGVVS-VLTKGNKEMKLSDGSYFGEICLLTRGRRTASVR 623

  Fly  1205 AETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAERLNKIGKNPNIMHQKDEQLSNPESNTITAV 1269
            |:|||.|:|||||:||.||::||:||:..||||.:||::|||..:|:..|.:.
Human   624 ADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQH------------ 676

  Fly  1270 VNALAAEADDCKDDDMDLKENLLHGSESS-IAEPVQTIREGLPRPRSGEFRALFEGNTP 1327
                            ||...:.:..|:: |.|.|:..||.:.:...|:...||....|
Human   677 ----------------DLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLFPPPPP 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	16/41 (39%)
		Ion_trans	771..1054	CDD:278921	159/282 (56%)
		Crp	1118..>1241	CDD:223736	84/122 (69%)
		CAP_ED	1124..1233	CDD:237999	75/108 (69%)
HCN2	NP_001185.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..159		3/15 (20%)
		Involved in subunit assembly. /evidence=ECO:0000250	158..209		19/58 (33%)
		Ion_trans_N	167..209	CDD:285597	16/41 (39%)
		Ion_trans	229..474	CDD:278921	159/282 (56%)
		Crp	538..>673	CDD:223736	90/135 (67%)
		CAP_ED	544..652	CDD:237999	75/108 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..889
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	178	1.000	Domainoid score	I3565
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4011
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000897
OrthoInspector	1	1.000	-	-		otm42053
orthoMCL	1	0.900	-	-		OOG6_101339
Panther	1	1.100	-	-	O	PTHR45689
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8464
SonicParanoid	1	1.000	-	-		X717
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.790