DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ih and HCN3

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_065948.1	Gene:	HCN3 / 57657	HGNCID:	19183	Length:	774	Species:	Homo sapiens

Alignment Length:	582	Identity:	325/582 - (55%)
Similarity:	417/582 - (71%)	Gaps:	50/582 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   685 PKEEPMPNIPIVSEKVSANFLKSQLQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPC 749
            ||..|.|.             :..|.:..|||.|:.::::|||.||:..|:.|.|::|.|:|||.
Human    38 PKSGPEPK-------------RRHLGTLLQPTVNKFSLRVFGSHKAVEIEQERVKSAGAWIIHPY 89

  Fly   750 SSFRFYWDLCMLLLLVANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDN 814
            |.|||||||.||||:|.|||:|||.|:||.::.|..||.||.||||.||:|:|:||||||:.::.
Human    90 SDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEG 154

  Fly   815 AEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLA 879
            || ::|.|:.|...||||||.:|||||||:|||||    :::|:...|: ::....|||||:|..
Human   155 AE-ILLAPRAIRTRYLRTWFLVDLISSIPVDYIFL----VVELEPRLDA-EVYKTARALRIVRFT 213

  Fly   880 KLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVF 944
            |:|||:||||||||:||:.||||::.:.                              .::||..
Human   214 KILSLLRLLRLSRLIRYIHQWEEIFHMT------------------------------YDLASAV 248

  Fly   945 MRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSINELQESYWLEQYSWALFKAMSHMLCIG 1009
            :||||||.||||:.||.|||||||||||.||.:.|||||.:....|..|||.|||||||||||||
Human   249 VRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSHALFKAMSHMLCIG 313

  Fly  1010 YGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPR 1074
            ||:..|..:.|:||||||||.||||||:|:||||.||||||||||||:||.||||:||::.|||.
Human   314 YGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPA 378

  Fly  1075 DMRQRITEYFEHRYQGKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTK 1139
            |.||||.||:|||||||.||||.|||||||.|||::||:.||.|||.:|.||:||.:||:.|:||
Human   379 DTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTK 443

  Fly  1140 LKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYFGEICLLTNARRVASVR 1204
            |::|||||||::::||::|.||||||.|::. |:|.|...|.|:||||||||||||..||.||||
Human   444 LRFEVFQPGDLVVREGSVGRKMYFIQHGLLS-VLARGARDTRLTDGSYFGEICLLTRGRRTASVR 507

  Fly  1205 AETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAERLNKIGKNPNIMHQKDEQLSNPESNTI 1266
            |:|||.|:||||||||.||:::|:||:..||||.:||.:|||..:|:.:|..:.|...|..|
Human   508 ADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQRKRSEPSPGSSGGI 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	18/41 (44%)
		Ion_trans	771..1054	CDD:278921	154/282 (55%)
		Crp	1118..>1241	CDD:223736	76/122 (62%)
		CAP_ED	1124..1233	CDD:237999	68/108 (63%)
HCN3	NP_065948.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48		4/22 (18%)
		Involved in subunit assembly. /evidence=ECO:0000250	46..91		18/44 (41%)
		Ion_trans_N	49..91	CDD:285597	18/41 (44%)
		Ion_trans	111..358	CDD:278921	154/282 (55%)
		Interaction with KCTD3. /evidence=ECO:0000250\|UniProtKB:O88705	354..774		136/217 (63%)
		Crp	422..>560	CDD:223736	83/138 (60%)
		CAP_ED	428..536	CDD:237999	68/108 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	682..774
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144999
Domainoid	1	1.000	178	1.000	Domainoid score	I3565
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000897
OrthoInspector	1	1.000	-	-		otm42053
orthoMCL	1	0.900	-	-		OOG6_101339
Panther	1	1.100	-	-	LDO	PTHR45689
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8291
SonicParanoid	1	1.000	-	-		X717
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.770