DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ih and cnga1b

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	XP_701036.4	Gene:	cnga1b / 572249	ZFINID:	ZDB-GENE-110408-39	Length:	639	Species:	Danio rerio

Alignment Length:	557	Identity:	140/557 - (25%)
Similarity:	263/557 - (47%)	Gaps:	90/557 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   745 VIHPCSSFRFYWDLCMLLLLVANLIILPVAISFFND---DLSTRWIAFNCLSDTIFLIDIVVNFR 806
            |:.|..:..:.|...:...::.|.|.: :|.:.|.:   |....|...:.|||.::|:|:|...|
Zfish   113 VVDPAGNMYYNWLFVITCPVMYNWIFI-IARACFEELQGDYLILWFFLDYLSDAVYLLDMVFRTR 176

  Fly   807 TGIMQQDNAEQVILDPKLIAKHYLRT-WFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAG 870
            ||.::|.   .::.|.|.:...|..: .|.|||.|.:|.|..:|.|                  |
Zfish   177 TGYLEQG---LLVKDQKKLRDRYTDSLQFRLDLASMVPTDIFYLYF------------------G 220

  Fly   871 RALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLIL 935
            .....:|:.|      |||::||..:..:.|                           |::|
Zfish   221 MNYPEIRMNK------LLRINRLFEFFQRTE---------------------------TRTN--- 249

  Fly   936 KFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSINELQESY--WLEQYSWAL 998
             |.|:    .||.||:..:::|.||:.|:.:......||.|:::|..:.....:  .:.:|::::
Zfish   250 -FPNV----FRISNLVMYIVIIIHWNACMYYSFSKAIGFGSDAFVYPDPSDPEFGRLVRKYAYSM 309

  Fly   999 FKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQV 1063
            :.:...:..||... ||...::.:..:...:.|...:|..:|:..::|.:.:::|..::.::..:
Zfish   310 YWSTLTLTTIGETP-PPVENSEYFFVVTDFLVGVLIFATIVGNVGSMITNANAARADFQARIDAI 373

  Fly  1064 EEYMAYRKLPRDMRQRITEYFEHRYQG-KFFDEELILGELSEKLREDV-INYNCRSLVASVPFFA 1126
            ::||::||:.:|:.:|:.::|::.:.. |..||..:|..|.:|||.:: ||.:..:| ..|..||
Zfish   374 KQYMSFRKVTKDLEKRVIKWFDYLWTNKKAVDEREVLKYLPDKLRAEIAINVHLDTL-KKVRIFA 437

  Fly  1127 NADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVA-TSLSDGSYFGE 1190
            :.::..:.::|.||:.:|:.|||.|.|:|.||.:||.|:||.:.:|..:|... ..|||||||||
Zfish   438 DCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGITQFVVLSDGSYFGE 502

  Fly  1191 ICLL------TNARRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAE---------- 1239
            |.:|      ...||.|::|:..|.:||.||.|.....|.:||..:..:|....:
Zfish   503 ISILNIKGSRAGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPDAKAMLEEKGRQILMKDNLLDL 567

  Fly  1240 RLNKIGKNPNIMHQKDEQLSNPESNTITAVVNALAAE 1276
            .|.|.|.:|..|.:|.:::.....:..|.....||.:
Zfish   568 ELAKQGPDPKDMEEKVQKIGGVLEDLQTRFARLLAEQ 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	2/5 (40%)
		Ion_trans	771..1054	CDD:278921	60/288 (21%)
		Crp	1118..>1241	CDD:223736	48/139 (35%)
		CAP_ED	1124..1233	CDD:237999	45/115 (39%)
cnga1b	XP_701036.4	Ion_trans	151..363	CDD:278921	58/274 (21%)
		Crp	429..629	CDD:223736	57/177 (32%)
		CAP_ED	435..551	CDD:237999	45/115 (39%)
		CLZ	551..621	CDD:293134	10/54 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920