Protein Alignment Ih and cngb1a

DIOPT Version :10

• Sequence 1: NP_001033948.1
• Gene: Ih / 36589
• FlyBaseID: FBgn0263397
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: XP_009292121.1
• Gene: cngb1a / 568211
• ZFINID: ZDB-GENE-050419-164
• Length: 1302
• Species: Danio rerio
• Alignment Length: 1351
• Identity: 270/1351 - (19%)
• Similarity: 475/1351 - (35%)
• Gaps: 363/1351 - (26%)

  Fly    68 PDSVSLLRAGDDQQQHPQQPHLQQQQQQQQHLQQQQQRHRSSSSRLSTSGISKQNSSDSRSGLRI 132
            ||:...|...|..:.:...|...::::.:|...:.::.            ||::|||.|
Zfish    13 PDAPGKLGEEDKNKTNDAAPEATKKEEAKQETSKPKEE------------ISEENSSQS------ 59

  Fly   133 LDSSHSPVSCGTQSVSSTGGQSALYDACHEYSRSLSAAAAEGAASLLKSHYSDQQ---------L 188
                      |..|..|.|..|||... ...|:..:|...:.|.::..|:.|||.         |
Zfish    60 ----------GVLSWLSQGFSSALPQP-GSSSKLGNAEVKQEANAVSNSNTSDQAGMIGWIVQGL 113

  Fly   189 AQTEPDPEPDPERDRDRDRDRDRDRERERRHLTNLNLNLSSEYDYSGSDKQQLVNETYIFKCIAN 253
            .:..|.|:.                                  .|.|..:.:.|.|
Zfish   114 GKVVPQPDE----------------------------------KYKGHTEPEEVTE--------- 135

  Fly   254 SPSFLRTNKIKEQSKKLRNLSLKTRTAKKKGQIISKSNAVSDNSLHPGDKYLNLYLVE-KKHSLQ 317
             |:.:...|:....::::|:......|.     |.....|||......:...:..::| .||..:
Zfish   136 -PAAVPVVKVDPPVQEIKNVRADDLVAD-----IPVVEVVSDEETDAANVPFSPRVIEWIKHGFE 194

  Fly   318 ------------PQVASTSSS------------------INTTHPQASSAPASSSSTCTKAPQLP 352
                        |..|.|.:.                  ..|..|..:.|||.:......||..|
Zfish   195 KVIPQSPMHLRPPSAAETPAQRAASAPATPCKQEPAPAPAPTPAPPPAPAPAPAPPPPPAAPPAP 259

  Fly   353 ALSAVAARQQQ----------LLLNGSLKGKGQSQSQGQSRQTLPGHRASVRSESGSGSSHTI-- 405
            |.:...|..:|          .::...::|.|:...|...:.          .|.||.....:
Zfish   260 APAPTPAAPEQPKAAEDSKGNNMVGWIVQGLGRMMPQPVLKP----------KEDGSDIVQNVCI 314

  Fly   406 ----------------PATGKSPPVPHSLAAKISSSASGSKNCNLLSASSNSCHKLNAHAQGSGA 454
                            .|..:...||.....:..||       .||....|....:.|..:...|
Zfish   315 LQDPCDMVLEEVDSDWEADQREQDVPQDPPLQQESS-------TLLQVLPNILPHVLAMQEQEDA 372

  Fly   455 GSGSGSGSGSGPPGHSHYAAASPKSSVSSNGHLNK------YCLTDLTRRKAEFN-RQLSAPTDY 512
            .:.:...:   |...|....|...:..:....|.:      ....||.|:.||.. |||.  .::
Zfish   373 ETQTERWT---PLIESIKKEAEETAIANMEERLQQERVEAARMAEDLARQAAELAVRQLE--EEH 432

  Fly   513 THHSSSNGSQQEGSSE------ANEGHEPVGESTITVASAGVSYPH--------PYSYPYHYAHH 563
            |.........:|..:|      ..|.:|...||.:.|..|..| ||        |.|........
Zfish   433 TAQIIIETKTEEPENEEQLPNIQEEENEEDAESLVDVCPAEPS-PHESEISDQPPQSPALSQEEP 496

  Fly   564 AS-----SATAPANLKASLQLHSFG-SHHPCPYPA------------------RPTSTSCT---- 600
            .|     :.:.||:.:...:....| ....|..||                  .|.|.|.|
Zfish   497 VSTQPERTTSPPADAEQEEEPADEGCGESTCVKPALTVEEVGDGGMTLPKIIVPPESDSMTLTVP 561

  Fly   601 --NSFNRRHIRRHKGK---LGDRLLSGDSEESVRCSYCSVLNVNDNDLRISFENTCTDSLVTAFD 660
              |...|..:...:.|   |.:.:..|:.||       ..::||.:||....|.  .:..::|..
Zfish   562 GANLTARSKVVDSESKPEDLEEAVPGGEDEE-------GKMDVNKSDLLNVDEG--LERPMSAAS 617

  Fly   661 DEALLICDQGTEMVHF------------------DDVSLYGTPKEEP---MPNIPIVSEKVSANF 704
            ..::::.::..|:|..                  ||.|...:|.::|   .|..|...:|..|.
Zfish   618 QTSIVVHERLQELVKLFKGRTERRRDKLVDPDESDDESPSASPAKKPGEAPPPPPPPEQKKEAE- 681

  Fly   705 LKSQLQSWFQPTDNRLAMKLFGSRKALVKE-RIRQKTSGHWVIHPCSSFRF------YWDLCMLL 762
                 :...:..:..:.:..|...|..|.: :|.|..  .| :....::||      |.||..::
Zfish   682 -----EKPVEEEEEEVQIYEFMGYKIPVPQFKIPQMP--EW-LRAILAYRFPSSIDPYTDLIYVV 738

  Fly   763 LLVA-------NLIILPVAISF--FNDDLSTRWIAFNCLSDTIFLIDI-VVNFRTGIMQQDNAEQ 817
            .|..       |:.::||..:|  ...|....|:..:...|:|:::|| ||..|   :|......
Zfish   739 WLFFVTFAWNWNVWLIPVRCTFPYQTPDNIHWWLLMDYFCDSIYIMDIFVVQPR---LQFVRGGD 800

  Fly   818 VILDPKLIAKHYLRT-WFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKL 881
            ::.|...:.::|.:| .|.:|:||..|||.:: :|..:..
Zfish   801 IVCDKNDMRENYRQTERFKMDVISLFPLDVLY-VFTGVKS------------------------- 839

  Fly   882 LSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMR 946
                 |||..||::|.:.:|                  .|.:.:..::|:.:           .|
Zfish   840 -----LLRFPRLLKYNAFFE------------------FNDRLEAWMSKAYI-----------YR 870

  Fly   947 IFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSINELQESYWLEQYSWALFKAMSHMLCIGYG 1011
            :......:|...|.:.|:.:.....:|..|..|| .|....|| :..|    :.|:..::.|| |
Zfish   871 VIRTSAYLLYSLHCNACIFYWGSDYEGLGSTKWV-YNGKGNSY-IRCY----YFAVKTLITIG-G 928

  Fly  1012 RFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDM 1076
            ...|.::.::...:::...|...:::.:|...::|.:..:....||..|....:||...::|||:
Zfish   929 LPDPTTVFEIVFQLVNYFVGVFAFSIMIGQMRDVIGAATAGEAYYRHSVDSTVKYMTSYRIPRDV 993

  Fly  1077 RQRITEYFEHRYQGK-FFDEELILGELSEKLREDV---INYNCRSLVASVPFFANADSNFVSDVV 1137
            :.||..::::.::.: ..||:.:|.:|.:|:|.|:   :||   |:|:.|..|...|...:.|::
Zfish   994 QNRIKTWYDYTWKSQGMLDEQELLIQLPDKMRLDIAADVNY---SIVSKVALFQGCDRQMIFDML 1055

  Fly  1138 TKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMA-NGE-VATSLSDGSYFGEICLLTNA--- 1197
            .:||..|:.|||.:.::|.||.:||.|:.|.|.:|.. :|: |..:|..||.||||.||...
Zfish  1056 KRLKSVVYLPGDFVCEKGEIGREMYIIKAGEVQVVGGPDGKTVFVTLRAGSVFGEISLLAGGGGN 1120

  Fly  1198 RRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAERLNKIGKNP 1248
            ||.|:|:|..:.|||.|.......:|..||..:|.:...|.:.|.| .|.|
Zfish  1121 RRTANVKAHGFANLFILDKKDLAEILVHYPESQKLLRKKAKKMLTK-DKKP 1170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:400630	6/42 (14%)
		PLN03192	741..>1214	CDD:215625	120/498 (24%)
cngb1a	XP_009292121.1	DamX	<331..>518	CDD:442497	39/199 (20%)
		YqiK	<365..>450	CDD:441869	17/89 (19%)
		PLN03192	736..>1114	CDD:215625	104/450 (23%)