DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ih and cngb1a

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	XP_696619.6	Gene:	cngb1a / 568211	ZFINID:	ZDB-GENE-050419-164	Length:	1326	Species:	Danio rerio

Alignment Length:	1373	Identity:	271/1373 - (19%)
Similarity:	478/1373 - (34%)	Gaps:	383/1373 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 PDSVSLLRAGDDQQQHPQQPHLQQQQQQQQHLQQQQQRHRSSSSRLSTSGISKQNSSDSRSGLRI 132
            ||:...|...|..:.:...|...::::.:|...:.::.            ||::|||.|
Zfish    13 PDAPGKLGEEDKNKTNDAAPEATKKEEAKQETSKPKEE------------ISEENSSQS------ 59

  Fly   133 LDSSHSPVSCGTQSVSSTGGQSALYDACHEYSRSLSAAAAEGAASLLKSHYSDQQ---------L 188
                      |..|..|.|..|||... ...|:..:|...:.|.::..|:.|||.         |
Zfish    60 ----------GVLSWLSQGFSSALPQP-GSSSKLGNAEVKQEANAVSNSNTSDQAGMIGWIVQGL 113

  Fly   189 AQTEPDPEPDPERDRDRDRDRDRDRERERRHLTNLNLNLSSEYDYSGSDKQQLVNETYIFKCIAN 253
            .:..|.|:.                                  .|.|..:.:.|.|
Zfish   114 GKVVPQPDE----------------------------------KYKGHTEPEEVTE--------- 135

  Fly   254 SPSFLRTNKIKEQSKKLRNLSLKTRTAKKKGQIISKSNAVSDNSLHPGDKYLNLYLVE-KKHSLQ 317
             |:.:...|:....::::|:......|.     |.....|||......:...:..::| .||..:
Zfish   136 -PAAVPVVKVDPPVQEIKNVRADDLVAD-----IPVVEVVSDEETDAANVPFSPRVIEWIKHGFE 194

  Fly   318 ------------PQVASTSSS------------------INTTHPQASSAPASSSSTCTKAPQLP 352
                        |..|.|.:.                  ..|..|..:.|||.:......||..|
Zfish   195 KVIPQSPMHLRPPSAAETPAQRAASAPATPCKQEPAPAPAPTPAPPPAPAPAPAPPPPPAAPPAP 259

  Fly   353 ALSAVAARQQQ----------LLLNGSLKGKGQSQSQGQSRQTLPGHRASVRSESGSGSSHTI-- 405
            |.:...|..:|          .::...::|.|:...|...:.          .|.||.....:
Zfish   260 APAPTPAAPEQPKAAEDSKGNNMVGWIVQGLGRMMPQPVLKP----------KEDGSDIVQNVCI 314

  Fly   406 ----------------PATGKSPPVPHSLAAKISSSASGSKNCNLLSASSNSCHKLNAHAQGSGA 454
                            .|..:...||.....:..||       .||....|....:.|..:...|
Zfish   315 LQDPCDMVLEEVDSDWEADQREQDVPQDPPLQQESS-------TLLQVLPNILPHVLAMQEQEDA 372

  Fly   455 GSGSGSGSGSGPPGHSHYAAASPKSSVSSNGHLNK------YCLTDLTRRKAEFN-RQL------ 506
            .:.:...:   |...|....|...:..:....|.:      ....||.|:.||.. |||
Zfish   373 ETQTERWT---PLIESIKKEAEETAIANMEERLQQERVEAARMAEDLARQAAELAVRQLEEEHTA 434

  Fly   507 ----SAPTDYTHHSSSNGSQQEGSSEANEGHEPVGE------------------STITVASAGVS 549
                ...|:...:.....:.||..:|.:...:|:||                  |.:.|..|..|
Zfish   435 QIIIETKTEEPENEEQLPNIQEEENEEDAELQPLGEESEEESEDSKISEADMKRSLVDVCPAEPS 499

  Fly   550 YPH--------PYSYPYHYAHHAS-----SATAPANLKASLQLHSFG-SHHPCPYPA-------- 592
             ||        |.|.........|     :.:.||:.:...:....| ....|..||
Zfish   500 -PHESEISDQPPQSPALSQEEPVSTQPERTTSPPADAEQEEEPADEGCGESTCVKPALTVEEVGD 563

  Fly   593 ----------RPTSTSCT------NSFNRRHIRRHKGK---LGDRLLSGDSEESVRCSYCSVLNV 638
                      .|.|.|.|      |...|..:...:.|   |.:.:..|:.||       ..::|
Zfish   564 GGMTLPKIIVPPESDSMTLTVPGANLTARSKVVDSESKPEDLEEAVPGGEDEE-------GKMDV 621

  Fly   639 NDNDLRISFENTCTDSLVTAFDDEALLICDQGTEMVHF------------------DDVSLYGTP 685
            |.:||....|.  .:..::|....::::.::..|:|..                  ||.|...:|
Zfish   622 NKSDLLNVDEG--LERPMSAASQTSIVVHERLQELVKLFKGRTERRRDKLVDPDESDDESPSASP 684

  Fly   686 KEEP---MPNIPIVSEKVSANFLKSQLQSWFQPTDNRLAMKLFGSRKALVKE-RIRQKTSGHWVI 746
            .::|   .|..|...:|..|.      :...:..:..:.:..|...|..|.: :|.|..  .| :
Zfish   685 AKKPGEAPPPPPPPEQKKEAE------EKPVEEEEEEVQIYEFMGYKIPVPQFKIPQMP--EW-L 740

  Fly   747 HPCSSFRF------YWDLCMLLLLVA-------NLIILPVAISF--FNDDLSTRWIAFNCLSDTI 796
            ....::||      |.||..::.|..       |:.::||..:|  ...|....|:..:...|:|
Zfish   741 RAILAYRFPSSIDPYTDLIYVVWLFFVTFAWNWNVWLIPVRCTFPYQTPDNIHWWLLMDYFCDSI 805

  Fly   797 FLIDI-VVNFRTGIMQQDNAEQVILDPKLIAKHYLRT-WFFLDLISSIPLDYIFLIFNQIMKLQD 859
            :::|| ||..|   :|......::.|...:.::|.:| .|.:|:||..|||.:: :|..:..
Zfish   806 YIMDIFVVQPR---LQFVRGGDIVCDKNDMRENYRQTERFKMDVISLFPLDVLY-VFTGVKS--- 863

  Fly   860 FSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRKD 924
                                       |||..||::|.:.:|                  .|.:.
Zfish   864 ---------------------------LLRFPRLLKYNAFFE------------------FNDRL 883

  Fly   925 KDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSINELQESY 989
            :..::|:.:           .|:......:|...|.:.|:.:.....:|..|..|| .|....||
Zfish   884 EAWMSKAYI-----------YRVIRTSAYLLYSLHCNACIFYWGSDYEGLGSTKWV-YNGKGNSY 936

  Fly   990 WLEQYSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRR 1054
             :..|    :.|:..::.|| |...|.::.::...:::...|...:::.:|...::|.:..:...
Zfish   937 -IRCY----YFAVKTLITIG-GLPDPTTVFEIVFQLVNYFVGVFAFSIMIGQMRDVIGAATAGEA 995

  Fly  1055 QYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRYQGK-FFDEELILGELSEKLREDV---INYNC 1115
            .||..|....:||...::|||::.||..::::.::.: ..||:.:|.:|.:|:|.|:   :||
Zfish   996 YYRHSVDSTVKYMTSYRIPRDVQNRIKTWYDYTWKSQGMLDEQELLIQLPDKMRLDIAADVNY-- 1058

  Fly  1116 RSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMA-NGE-V 1178
             |:|:.|..|...|...:.|::.:||..|:.|||.:.::|.||.:||.|:.|.|.:|.. :|: |
Zfish  1059 -SIVSKVALFQGCDRQMIFDMLKRLKSVVYLPGDFVCEKGEIGREMYIIKAGEVQVVGGPDGKTV 1122

  Fly  1179 ATSLSDGSYFGEICLLTNA---RRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAER 1240
            ..:|..||.||||.||...   ||.|:|:|..:.|||.|.......:|..||..:|.:...|.:.
Zfish  1123 FVTLRAGSVFGEISLLAGGGGNRRTANVKAHGFANLFILDKKDLAEILVHYPESQKLLRKKAKKM 1187

  Fly  1241 LNKIGKNP 1248
            |.| .|.|
Zfish  1188 LTK-DKKP 1194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	6/42 (14%)
		Ion_trans	771..1054	CDD:278921	53/286 (19%)
		Crp	1118..>1241	CDD:223736	45/127 (35%)
		CAP_ED	1124..1233	CDD:237999	42/113 (37%)
cngb1a	XP_696619.6	ATP-synt_B	<384..450	CDD:304375	12/65 (18%)
		Ion_trans	780..992	CDD:278921	52/281 (19%)
		Crp	1060..>1188	CDD:223736	45/127 (35%)
		CAP_ED	1066..1175	CDD:237999	40/108 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920