DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ih and hcn3

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	XP_689197.1	Gene:	hcn3 / 560709	ZFINID:	ZDB-GENE-060503-193	Length:	639	Species:	Danio rerio

Alignment Length:	659	Identity:	323/659 - (49%)
Similarity:	429/659 - (65%)	Gaps:	95/659 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   619 LLSGDSEESVRCSYCSVLNVN-----------DNDLRISF---ENTCTDSLVTAFDDEALLICDQ 669
            ||.|::|:..| ...|::|.|           ...|.::.   ..|.|.:.|||
Zfish    34 LLRGEAEDVSR-RLLSIVNHNQERSDSGASPTSKSLEVTAGLDGTTATTTTVTA----------- 86

  Fly   670 GTEMVHFDDVSLYGTPKEEPMPN--------IPIVSEKV------SANFLKSQLQSWFQPTDNRL 720
                         .||   |:|:        .|:.||..      .:.||:.|..|..||..|:.
Zfish    87 -------------ATP---PLPHKAMPESSGAPVASEAEDGPFVDQSTFLQRQFSSMLQPGVNKF 135

  Fly   721 AMKLFGSRKALVKERIRQKTSGHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISFFNDDLSTR 785
            ::::|||.|.:..|:.|.|:.|.|:|||.|.|||||||.||.|::.||:|||..|:||.|..:..
Zfish   136 SLRMFGSAKGVAAEQDRVKSFGVWIIHPYSDFRFYWDLVMLCLMMGNLVILPWGITFFEDQNTLP 200

  Fly   786 WIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLI 850
            ||.||..|||:||.|:|.|||||||:.||:| :||||::|::.|||.||.:|.|||||:|||||
Zfish   201 WITFNVASDTLFLADLVFNFRTGIMEGDNSE-IILDPQIISRRYLRGWFLVDFISSIPVDYIFL- 263

  Fly   851 FNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSAD 915
               |:.::...:|.::....|||||:|..|:|||:||||||||:||:.||||::.:.
Zfish   264 ---IVDIESRLESAEVYRTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMT-------- 317

  Fly   916 RRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWV 980
                                  .::||..:||.|||.||||:.||.||:||:|||||.|||..||
Zfish   318 ----------------------YDLASAVVRIVNLIGMMLLLCHWDGCMQFMVPMLQDFPSTCWV 360

  Fly   981 SINELQESYWLEQYSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNL 1045
            |.|.:..|.|..|||:|||.|||||||||||...|:..||:||||:|||.||||||:|||:||||
Zfish   361 SKNNMVNSTWDVQYSYALFMAMSHMLCIGYGAQAPEGPTDVWLTMISMIIGATCYAMFLGNATNL 425

  Fly  1046 IQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRYQGKFFDEELILGELSEKLREDV 1110
            :||||:|.|||:||.||||:||::.|||.||||||.:|:|||:|||.||||.||.|||:.|:|::
Zfish   426 VQSLDASHRQYQEKYKQVEQYMSFHKLPADMRQRIHDYYEHRFQGKMFDEENILEELSDPLKEEI 490

  Fly  1111 INYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMAN 1175
            :|||||.|||::|.|||||.:||:.:::||::|||||||:||:|||:|.||||||.|.|.::.::
Zfish   491 VNYNCRGLVANMPLFANADPHFVTVLLSKLRFEVFQPGDVIIREGTLGRKMYFIQHGCVSVITSD 555

  Fly  1176 GEVATSLSDGSYFGEICLLTNARRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAER 1240
            .: ...|:||.|||||||||..||.|||||:|||.|:|||||.||.||::.||||:..|.||
Zfish   556 NK-EKKLNDGCYFGEICLLTRGRRTASVRADTYCRLYSLSVDSFNEVLEENPLMRRAFENVA--- 616

  Fly  1241 LNKIGKNPN 1249
            :|::|:..|
Zfish   617 VNRLGRESN 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	16/41 (39%)
		Ion_trans	771..1054	CDD:278921	150/282 (53%)
		Crp	1118..>1241	CDD:223736	73/122 (60%)
		CAP_ED	1124..1233	CDD:237999	66/108 (61%)
hcn3	XP_689197.1	Ion_trans_N	124..166	CDD:285597	16/41 (39%)
		Ion_trans	186..429	CDD:278921	146/277 (53%)
		Ion_trans_2	<377..427	CDD:285168	37/49 (76%)
		Crp	498..>622	CDD:223736	74/127 (58%)
		CAP_ED	504..612	CDD:237999	66/108 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	178	1.000	Domainoid score	I3510
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000897
OrthoInspector	1	1.000	-	-		otm25455
orthoMCL	1	0.900	-	-		OOG6_101339
Panther	1	1.100	-	-	LDO	PTHR45689
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X717
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.910