DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ih and kcnh7

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	XP_021332696.1	Gene:	kcnh7 / 560289	ZFINID:	ZDB-GENE-120214-39	Length:	1177	Species:	Danio rerio

Alignment Length:	940	Identity:	217/940 - (23%)
Similarity:	368/940 - (39%)	Gaps:	227/940 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   478 KSSVSSNGHLNKYCLTDLTRRKAEFNR-QLSA----------------PTDYTHHSSSNGSQQEG 525
            :.|:.|...||........::|..|.| :|.|                |.:.|.||:....:...
Zfish   135 EGSMDSLDRLNHTSPARQEQKKGRFFRFRLPAPLSMLGVSKQSLPQEDPDEVTIHSADQNEKHSS 199

  Fly   526 SSEA-------NEGHEPVGES------TITVASAGVSY---------PHPYSYP----YHYAHHA 564
            .|.:       .|.|.|.|||      ..|.|..|.||         |..:|.|    .......
Zfish   200 CSSSLSLSLSPRELHPPTGESCSPSYGNDTRALIGQSYLGSCSPISGPQDHSSPRGPWERVDPQE 264

  Fly   565 SSATAPANL-KASLQLHSFGSHHPCPYPARPTSTSCTNSFNRRHIRRHKGKLGDRLLSGDSEESV 628
            |.|||.... :||:          |.: .|.:||......:....|.::    ||..|.|:..|:
Zfish   265 SLATASRRASRASM----------CTF-RRASSTQDLEGLSTHTQRTYR----DRHASEDNGRSI 314

  Fly   629 RCSYCSVLNVNDNDLRISFENTCTDSLVTAFD--DEALLICDQGTEMVHFDDVSLYGTPKEEPMP 691
            :.|...:.....|.::.|...:.:||.:|.:.  ::..||....:|..|            :..|
Zfish   315 KVSRSWMAGGPFNQIKSSLLGSTSDSNLTKYSTINKIPLITLNFSETNH------------DKRP 367

  Fly   692 NIPIVSEK-VSANFLKSQLQSWFQPTDNRLAMKLFGS----RKALVKERIRQKTSGHWVIHPCSS 751
            :.|..||| :.|..:|.:..:   .||....:...|:    ...|...||.:.|..|:     |.
Zfish   368 SSPHSSEKTIIAPKVKDRTHN---VTDKVTQVLSLGADVLPEYKLQTPRINKLTILHY-----SP 424

  Fly   752 FRFYWDLCMLLLLVANLIILPVAISF-FND--DLSTRWIAFNC--------LSDTIFLIDIVVNF 805
            |:..||..:|||::...|..|.:.:| .||  :...|...::|        :.|.:|::||::||
Zfish   425 FKAVWDWLILLLVIYTAIFTPYSAAFLLNDPEEEKRRECGYSCSPLNVVDLIVDIMFIVDILINF 489

  Fly   806 RTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAG 870
            ||..:..:  |:|:..|..||.||.:.|||:|::::||.|  .|||      :..||....|
Zfish   490 RTTYINAN--EEVVSHPAKIAVHYFKGWFFIDMVAAIPFD--LLIF------EGGSDETTTL--- 541

  Fly   871 RALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLIL 935
              :.:|:.|:||.|||:.|  :|.||......|.:|
Zfish   542 --IGLLKTARLLRLVRVAR--KLDRYSEYGAAVLML----------------------------- 573

  Fly   936 KFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSINELQESY------WL--- 991
                          |:|:..||.||..|:              |.:|..::..|      ||
Zfish   574 --------------LMCIFALIAHWLACI--------------WYAIGNVERLYLDHTIGWLDNL 610

  Fly   992 --------------------EQYSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYA 1036
                                ::|..||:...|.:..:|:|...|.:.::...::..|:.|:..||
Zfish   611 GISIGKQYNISDDASGPSIRDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYA 675

  Fly  1037 LFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRY---QGKFFDEELI 1098
            ...|:.:.:||.|.|...:|..::.:|:|::.:.::|..:|||:.|||:|.:   .|...:.|::
Zfish   676 SIFGNVSAIIQRLYSGTARYHLQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMEVL 740

  Fly  1099 LGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYF 1163
            .| ..|.|:.|:..:..::|:.|...|..|....:..:..:.|.....|||.::..|.:.|.:||
Zfish   741 KG-FPECLQADICLHLNKTLLQSCKAFRGATKGCLRALAMRFKTTHAPPGDTLVHGGDVLTALYF 804

  Fly  1164 IQEGVVDIVMANGEVATSLSDGSYFGEICLL--TNARRVASVRAETYCNLFSLSVDHFNCVLDQY 1226
            :..|.::| :.:..|...|.....|||:..|  ...:..|.|||.:||:|.:::.:....|||.|
Zfish   805 LARGSIEI-LRDDIVVAILGKNDIFGEMIHLYAKPGKANADVRALSYCDLHTINREDLLEVLDMY 868

  Fly  1227 PLMRKTMETVAAERLNKIGKNPNIMHQKDEQLSNPESNTITAVVNALAAEADDCKDDDMDLKENL 1291
            |......       |:.:....|:..:..:..:.|:....|||        .|...:|.|:::.
Zfish   869 PEFSDYF-------LSNLELTFNLRDENSKDTTAPQRTLYTAV--------SDSDTEDPDVRKR- 917

  Fly  1292 LHGSESSIAEPVQTIREGLPRPRSGEFRAL 1321
                ..|...|::..|....|.|..|...|
Zfish   918 ----RRSTDSPIRPSRSDRERVRDRELHTL 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	8/45 (18%)
		Ion_trans	771..1054	CDD:278921	75/322 (23%)
		Crp	1118..>1241	CDD:223736	32/124 (26%)
		CAP_ED	1124..1233	CDD:237999	30/110 (27%)
kcnh7	XP_021332696.1	PAS_9	29..129	CDD:315989
		Ion_trans	428..690	CDD:306908	80/335 (24%)
		CAP_ED	765..876	CDD:237999	30/118 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910