Protein Alignment Ih and kcnh7

DIOPT Version :10

• Sequence 1: NP_001033948.1
• Gene: Ih / 36589
• FlyBaseID: FBgn0263397
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: XP_073809787.1
• Gene: kcnh7 / 560289
• ZFINID: ZDB-GENE-120214-39
• Length: 1213
• Species: Danio rerio
• Alignment Length: 940
• Identity: 214/940 - (22%)
• Similarity: 362/940 - (38%)
• Gaps: 243/940 - (25%)

  Fly   478 KSSVSSNGHLNKYCLTDLTRRKAEFNR-QLSA----------------PTDYTHHSSSNGSQQEG 525
            :.|:.|...||........::|..|.| :|.|                |.:.|.||:....:...
Zfish   187 EGSMDSLDRLNHTSPARQEQKKGRFFRFRLPAPLSMLGVSKQSLPQEDPDEVTIHSADQNEKHSS 251

  Fly   526 SSEA-------NEGHEPVGES------TITVASAGVSY---PHPYSYPYHYAHHAS--------- 565
            .|.:       .|.|.|.|||      ..|.|..|.||   ..|.|.|   ..|:|
Zfish   252 CSSSLSLSLSPRELHPPTGESCSPSYGNDTRALIGQSYLGSCSPISGP---QDHSSPRGPWERVD 313

  Fly   566 --SATAPANLKASLQLHSFGSHHPCPYPARPTSTSCTNSFNRRHIRRHKGKLGDRLLSGDSEESV 628
              .:.|.|:.:||                  .::.||       .||.........||..::.:.
Zfish   314 PQESLATASRRAS------------------RASMCT-------FRRASSTQDLEGLSTHTQRTY 353

  Fly   629 RCSYCSVLNVNDNDLRISFENTCTDSLVTAFD--DEALLICDQGTEMVHFDDVSLYGTPKEEPMP 691
            |..:.|  ....|.::.|...:.:||.:|.:.  ::..||....:|..|            :..|
Zfish   354 RDRHAS--EGPFNQIKSSLLGSTSDSNLTKYSTINKIPLITLNFSETNH------------DKRP 404

  Fly   692 NIPIVSEK-VSANFLKSQLQSWFQPTDNRLAMKLFGS----RKALVKERIRQKTSGHWVIHPCSS 751
            :.|..||| :.|..:|.:..:   .||....:...|:    ...|...||.:.|..|:     |.
Zfish   405 SSPHSSEKTIIAPKVKDRTHN---VTDKVTQVLSLGADVLPEYKLQTPRINKLTILHY-----SP 461

  Fly   752 FRFYWDLCMLLLLVANLIILPVAISF-FND--DLSTRWIAFNC--------LSDTIFLIDIVVNF 805
            |:..||..:|||::...|..|.:.:| .||  :...|...::|        :.|.:|::||::||
Zfish   462 FKAVWDWLILLLVIYTAIFTPYSAAFLLNDPEEEKRRECGYSCSPLNVVDLIVDIMFIVDILINF 526

  Fly   806 RTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAG 870
            ||..:..:  |:|:..|..||.||.:.|||:|::::||.|  .|||      :..||....|
Zfish   527 RTTYINAN--EEVVSHPAKIAVHYFKGWFFIDMVAAIPFD--LLIF------EGGSDETTTL--- 578

  Fly   871 RALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLIL 935
              :.:|:.|:||.|||:.|  :|.||......|.:|
Zfish   579 --IGLLKTARLLRLVRVAR--KLDRYSEYGAAVLML----------------------------- 610

  Fly   936 KFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSINELQESY------WL--- 991
                          |:|:..||.||..|:              |.:|..::..|      ||
Zfish   611 --------------LMCIFALIAHWLACI--------------WYAIGNVERLYLDHTIGWLDNL 647

  Fly   992 --------------------EQYSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYA 1036
                                ::|..||:...|.:..:|:|...|.:.::...::..|:.|:..||
Zfish   648 GISIGKQYNISDDASGPSIRDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYA 712

  Fly  1037 LFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRY---QGKFFDEELI 1098
            ...|:.:.:||.|.|...:|..::.:|:|::.:.::|..:|||:.|||:|.:   .|  .|..::
Zfish   713 SIFGNVSAIIQRLYSGTARYHLQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNG--IDMNMV 775

  Fly  1099 LGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYF 1163
            |....|.|:.|:..:..::|:.|...|..|....:..:..:.|.....|||.::..|.:.|.:||
Zfish   776 LKGFPECLQADICLHLNKTLLQSCKAFRGATKGCLRALAMRFKTTHAPPGDTLVHGGDVLTALYF 840

  Fly  1164 IQEGVVDIVMANGEVATSLSDGSYFGEICLL--TNARRVASVRAETYCNLFSLSVDHFNCVLDQY 1226
            :..|.::| :.:..|...|.....|||:..|  ...:..|.|||.:||:|.:::.:....|||.|
Zfish   841 LARGSIEI-LRDDIVVAILGKNDIFGEMIHLYAKPGKANADVRALSYCDLHTINREDLLEVLDMY 904

  Fly  1227 PLMRKTMETVAAERLNKIGKNPNIMHQKDEQLSNPESNTITAVVNALAAEADDCKDDDMDLKENL 1291
            |......       |:.:....|:..:..:..:.|:....|||        .|...:|.|:::.
Zfish   905 PEFSDYF-------LSNLELTFNLRDENSKDTTAPQRTLYTAV--------SDSDTEDPDVRKR- 953

  Fly  1292 LHGSESSIAEPVQTIREGLPRPRSGEFRAL 1321
                ..|...|::..|....|.|..|...|
Zfish   954 ----RRSTDSPIRPSRSDRERVRDRELHTL 979

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:400630	8/45 (18%)
		PLN03192	741..>1214	CDD:215625	128/517 (25%)
kcnh7	XP_073809787.1	None