Protein Alignment Ih and hcn4l

DIOPT Version :10

• Sequence 1: NP_001033948.1
• Gene: Ih / 36589
• FlyBaseID: FBgn0263397
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: XP_684730.6
• Gene: hcn4l / 556759
• ZFINID: ZDB-GENE-110411-3
• Length: 1188
• Species: Danio rerio
• Alignment Length: 760
• Identity: 359/760 - (47%)
• Similarity: 478/760 - (62%)
• Gaps: 110/760 - (14%)

  Fly   554 YSYPYHYAHHASSATAPANLKASLQLHSFGSHHPCPYPARPTSTSCTNSFNRRHIRRHKGKLGDR 618
            ||.|:.:.|..:......:.....:..|....|   :|: |:||..:           ||....:
Zfish    13 YSLPHQFGHKGAMNRDGEDSDKDTRRKSVKMKH---FPS-PSSTGSS-----------KGVCEAK 62

  Fly   619 LLSGDSEESVRCSYCSVLNVNDNDLRISFENTCTDSLVTAFD----DEALLICDQGTEMVHFDDV 679
              |||:|..|...:.:  |||.:..|.....:...|...|.|    ::..||.|...|    ||
Zfish    63 --SGDAETDVGRPFRT--NVNGDCRRFRGSLSSLTSRHAAPDADLAEQRRLIGDASPE----DD- 118

  Fly   680 SLYGTPKEEPMPN---------------------------------IPIVSEKVSANFLKSQLQS 711
                .|.|:|.|.                                 :|.......|.|:..|..:
Zfish   119 ----GPSEQPGPGESPGAQGGRGDGAQQAPSEEQSTFVKLEGIDQILPDDERMYQAGFMHRQFGA 179

  Fly   712 WFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAIS 776
            ..||..|:.::::|||.||:..|:.|.|::|.|:|||.|.|||||||.||||:|.||||:||.|:
Zfish   180 MLQPGVNKFSLRMFGSEKAVEHEQERVKSAGFWIIHPYSDFRFYWDLIMLLLMVGNLIIIPVGIT 244

  Fly   777 FFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISS 841
            ||.|:.:..||.||.:|||.||:|:|:||||||:::|:.| :||||:.|...|||:||.:|.:||
Zfish   245 FFKDEHTPAWIVFNVVSDTFFLVDLVLNFRTGIVKEDSTE-IILDPQQIKVRYLRSWFAVDFLSS 308

  Fly   842 IPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYIL 906
            ||:|||||    |::.:..||.::   ..|||||:|..|:|||:||||||||:||:.||||::.:
Zfish   309 IPVDYIFL----IVETRIDSDFYK---TARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHM 366

  Fly   907 QNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPML 971
            .                              .::||..:||.|||.||||:.||.||||||||||
Zfish   367 T------------------------------YDLASAMVRIVNLIGMMLLLCHWDGCLQFLVPML 401

  Fly   972 QGFPSNSWVSINELQESYWLEQYSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYA 1036
            |.|||:.||:.|::....|.:|||:|||||||||||||||.:||..:||:|||:||||.||||||
Zfish   402 QDFPSDCWVAKNKMVNDTWGQQYSYALFKAMSHMLCIGYGMYPPVGMTDVWLTILSMIVGATCYA 466

  Fly  1037 LFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRYQGKFFDEELILGE 1101
            :|:||||.||||||||||||:||.||||:||::.|||.||||||.:|:|||||||.||||.||||
Zfish   467 MFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQRIHDYYEHRYQGKMFDEESILGE 531

  Fly  1102 LSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQE 1166
            |:|.|||::|::|||.|||::|.|||||.|||:.::|||::|||||||.||:|||:|.||||||.
Zfish   532 LNEPLREEIISFNCRKLVATMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTVGKKMYFIQH 596

  Fly  1167 GVVDIVMANGEVATSLSDGSYFGEICLLTNARRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRK 1231
            ||: .|:..|...|.:|||||||||||||..||.|||||:|||.|:||||||||.||::||:||:
Zfish   597 GVL-TVLTKGSKETKISDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNEVLEEYPMMRR 660

  Fly  1232 TMETVAAERLNKIGKNPNIMHQKDEQ------LSNPESNTITAVV 1270
            ..||||.:||::|||..:::..|.::      |:..|:..|..:|
Zfish   661 AFETVALDRLDRIGKRNSVLQHKVQRDLNSGVLNYQENEIIQQIV 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:400630	16/41 (39%)
		PLN03192	741..>1214	CDD:215625	282/472 (60%)
hcn4l	XP_684730.6	None