Protein Alignment Ih and kcnh5a

DIOPT Version :10

• Sequence 1: NP_001033948.1
• Gene: Ih / 36589
• FlyBaseID: FBgn0263397
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: NP_001263209.1
• Gene: kcnh5a / 556304
• ZFINID: ZDB-GENE-061106-2
• Length: 1093
• Species: Danio rerio
• Alignment Length: 936
• Identity: 194/936 - (20%)
• Similarity: 322/936 - (34%)
• Gaps: 338/936 - (36%)

  Fly   625 EESVRCSYC-----------SVLNVNDNDLRISFENTCTDSLV------------------TAFD 660
            ::|..||:.           .|....||     :|:.|.:.|:                  ...|
Zfish    60 QKSSTCSFMYGELTDKKTIDKVRQTFDN-----YESNCFEVLLYKKNRTPVWLHMQVAPIRNEND 119

  Fly   661 DEALLICDQGTEMVHFDDVSLYGTPKEE---------------------------PMPNIPIVSE 698
            ...|.:|.       |.|::::..|.|:                           || |...||.
Zfish   120 KVVLFLCT-------FKDITVFKQPIEDETTRGWTKFARLTRALTNSRGTVQQLTPM-NKTEVSH 176

  Fly   699 KVSANFLKSQLQSWFQPTDNRLAMKL-FGSRKALVKERIRQKTSGHWVIHPCSSFRFYWDLCMLL 762
            |.|                 |||..| .||......::...||..|.::|.| :|:..||..:|:
Zfish   177 KHS-----------------RLAEALQLGSDILPQYKQEAPKTPPHIILHYC-TFKTTWDWVILI 223

  Fly   763 LLVANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAK 827
            |.....|::|..:||.....:..|:..:.:.|.|||:|||:||.|..:....  :||.|||||..
Zfish   224 LTFYTAIMVPYNVSFKTKQNNLVWLVLDSVVDVIFLVDIVLNFHTTFVGPGG--EVISDPKLIRM 286

  Fly   828 HYLRTWFFLDLISSIPLDYIFLIFNQIMKLQD--FSDSFQILH---AGRALR------------I 875
            :||:|||.:||:|.:|.|    |.|....:.:  |.||..:.|   ||.:.|            :
Zfish   287 NYLKTWFVIDLLSCLPYD----IINAFENVDEDTFVDSSAVGHLPSAGHSPRNATRAEDSVLPGL 347

  Fly   876 LRLAKLLSLVRLLRLSRLVR----YVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILK 936
            ..|...|.:||||||.|:.|    |:.....|.:|
Zfish   348 SSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVL------------------------------ 382

  Fly   937 FLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSI----------NELQESYWL 991
                         |:|:..|:.||..|:              |.||          |.|:...||
Zfish   383 -------------LVCVFGLVAHWLACI--------------WYSIGDYEVIDEATNSLKTDSWL 420

  Fly   992 EQ----------------------------YSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSM 1028
            .|                            |..:|:..|:.:..||:|...|.:..:...::..|
Zfish   421 YQLAISIGTPYRYNASGSGHWEGGPSKHTLYISSLYFTMTSLTTIGFGNIAPTTDGEKIFSVAMM 485

  Fly  1029 ISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRY-QGKF 1092
            :.|:..||...|:.|.:.|.:.::..:|.|.:..|.:::...::|:.:.:|:.:|....: ..|.
Zfish   486 MVGSLLYATIFGNVTTIFQQMYTNTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWAMTKG 550

  Fly  1093 FDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTI 1157
            .|.|.:|....:.:|.|:..:..|.:....|.|..|....:..:..:.:.....|||:|...|..
Zfish   551 IDTEKVLSICPKDMRADICVHLNRQVFNEHPAFRLASDGCLRSLAVEFQTTHCAPGDLIFHAGES 615

  Fly  1158 GTKMYFIQEGVVDIVMANGEVATSLSDGSYFGEICLLTN--ARRVASVRAETYCNLFSLSVDHFN 1220
            ...:.|:..|.::::. :.||...|..|..||::....:  |...|:|||.|||:|..:..|...
Zfish   616 VDTLCFVVSGSLEVIQ-DDEVIAILGKGDVFGDVFWKESSLAHACANVRALTYCDLHVIRRDALL 679

  Fly  1221 CVLDQYP--------------------LMRKTMETVAAERLNKIGKN------------------ 1247
            .||:.|.                    :.||..:....|...:..||
Zfish   680 KVLEFYTAFANSFSRNLILTCNLRKRIVFRKIADVKKEEEERRHQKNEVTLSIPVDHPVRKLFQK 744

  Fly  1248 -----------PN-----------------IMHQKDEQLSNPE---------------------- 1262
                       |:                 :.||..:|...|:
Zfish   745 FKQQKEMRTQGPSQYDLERNQFQVEHHLHPLSHQLHQQQYQPQYQGHHSLPHQHVAPMQNGAPGS 809

  Fly  1263 -----------SNTITAVVNALA-AEADDCK----DDDMDLKENLLHGSESS----IAEPVQTIR 1307
                       .:.||.:.:||| |:.::..    .:.|:||.|.  |:|.|    :..||
Zfish   810 GNGNGGSCVVTVSQITPIQSALAYAQTEETNMSEGHEAMELKPNF--GAEDSNCLKVTSPV---- 868

  Fly  1308 EGLPRPRSGE------FRALFEGNTP 1327
                :||:|:      |..:..|::|
Zfish   869 ----KPRAGKGRGWMRFHNIASGSSP 890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:400630	11/42 (26%)
		PLN03192	741..>1214	CDD:215625	128/534 (24%)
kcnh5a	NP_001263209.1	PAS_9	39..132	CDD:463873	14/83 (17%)
		PLN03192	217..>648	CDD:215625	115/494 (23%)
		cyc_nuc_ocin	<606..705	CDD:274839	25/99 (25%)