DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ih and Cngb3

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_001258167.1	Gene:	Cngb3 / 500418	RGDID:	1565364	Length:	690	Species:	Rattus norvegicus

Alignment Length:	782	Identity:	160/782 - (20%)
Similarity:	288/782 - (36%)	Gaps:	222/782 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   503 NRQLSAPTDYT---HHSSSNGSQQEGS---SEANEGHEPVGESTITVASAGVSYPHPYSYPYHYA 561
            |..|.:.|..|   .||..:.|..|.|   |..|...|...|.|.|::              ...
  Rat    44 NESLMSRTPATVEKSHSKEDNSTGENSLRGSTTNPDTECPAELTGTIS--------------EME 94

  Fly   562 HHASSATAPANLKASLQLHSFGSHHPCPYPARPTSTSCTNSFNRRHIRRHKGKLGDR-------L 619
            ...:....||::|..:                 ..||..|.:...|:.....::.:|       |
  Rat    95 QTRTRKEKPASIKTKV-----------------FETSIINEYTDAHLHNLVERMRERTAFYKRTL 142

  Fly   620 LSGDSEESVRCSYCSVLNVNDNDLRISFENTCTDSLVTAFDDEALLICDQGTEMVHFDDVSLYGT 684
            ..|::...:..|                .:|.|.:                       |:|
  Rat   143 TEGENSPELEAS----------------SHTATST-----------------------DIS---- 164

  Fly   685 PKEEPMPNIPIVSEKVSANFLKSQLQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPC 749
            |::|       ::.|...:..|.|                    :..|||.:|.       :...
  Rat   165 PRQE-------INSKPKEHHHKLQ--------------------RVPVKEYLRS-------MRLP 195

  Fly   750 SSFRFYWD----LCMLLLLVA---NLIILPVAISF--FNDDLSTRWIAFNCLSDTIFLIDI-VVN 804
            .|...|.|    |.:||:.:|   |..:|||.:.|  ...|....||..:.:.|.|:|.|| ::.
  Rat   196 RSIDSYTDRIYLLWLLLVTIAYNWNCWLLPVRLVFPCQTPDNRNYWIITDIICDIIYLGDILLIQ 260

  Fly   805 FRTGIMQQDNAEQVILDPKLIAKHY-LRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILH 868
            .|   :|.....::|:|...:.:|| ..|.|.:|:.|.:|.:.:::.|
  Rat   261 PR---LQFVRGGEIIVDSNELKRHYRSSTKFQMDVASLLPFEVLYIFF----------------- 305

  Fly   869 AGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNL 933
                          .:..:.|.:|:::|.|.:|..:.|:::
  Rat   306 --------------GVNPIFRTNRILKYTSFFEFNHHLESI------------------------ 332

  Fly   934 ILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSINE----LQESYWLEQY 994
                ::.|.|: ||......:|.:.|.:.|:.:.....:|..|..||...|    |:..||
  Rat   333 ----MDRAYVY-RIIRTTGYLLFLLHINACVYYWASDYEGIGSTKWVYNGEGNKYLRCFYW---- 388

  Fly   995 SWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREK 1059
                  |:..::.|| |...||:..::...:|:..||...::..:|...::|.:..:::..:...
  Rat   389 ------AVRTLITIG-GLPEPQTSFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNNFHVC 446

  Fly  1060 VKQVEEYMAYRKLPRDMRQRITEYFEHRYQG-KFFDEELILGELSEKLREDV---INYNCRSLVA 1120
            :..:..||....:|:..:.|:..:.|:.:.. :..||..:|..|...::..|   ||:|   ::.
  Rat   447 MDHIIAYMNKYSIPQSTQHRVRTWLEYTWHSQRILDESNLLETLPTAMQLSVAIDINFN---IID 508

  Fly  1121 SVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMA--NGEVATSLS 1183
            .|..|...|:..:.|::.:||..::.|||.:.|:|.||.:||.|:.|.|.::..  ..:|..:|.
  Rat   509 KVELFKGCDTQMIYDLLLRLKSTIYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGAQVLVTLK 573

  Fly  1184 DGSYFGEICLLTNA---RRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAERLNKIG 1245
            .|:.||||.||...   ||.|.|.|..:.||.:|.......:|..||..:|.:...|...|::.|
  Rat   574 AGAVFGEISLLAKGGGNRRTADVVAHGFANLLTLDKKTLQEILLHYPTSKKLLMKKAKVLLSQKG 638

  Fly  1246 KN 1247
            ||
  Rat   639 KN 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	4/41 (10%)
		Ion_trans	771..1054	CDD:278921	56/290 (19%)
		Crp	1118..>1241	CDD:223736	40/127 (31%)
		CAP_ED	1124..1233	CDD:237999	38/113 (34%)
Cngb3	NP_001258167.1	CAP_ED	512..620	CDD:237999	35/107 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920