Protein Alignment Ih and Kcnh4

DIOPT Version :10

• Sequence 1: NP_001033948.1
• Gene: Ih / 36589
• FlyBaseID: FBgn0263397
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: NP_001074663.1
• Gene: Kcnh4 / 380728
• MGIID: 2156184
• Length: 1018
• Species: Mus musculus
• Alignment Length: 640
• Identity: 147/640 - (22%)
• Similarity: 256/640 - (40%)
• Gaps: 171/640 - (26%)

  Fly   688 EPMPNIPIVSEKVSANFLKSQLQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSSF 752
            ||.|::|  ..||::                     :.|||..|:          |:.|.
Mouse   199 EPKPSVP--EYKVAS---------------------VGGSRCLLL----------HYSIP----- 225

  Fly   753 RFYWDLCMLLLLVANLIILPVAISFFNDD----LSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQD 813
            :..||..:||......:.:|..:.|..||    .|...:..:...:.:|::||::||||..:.|.
Mouse   226 KAVWDGLILLATFYVAVTVPYNVCFAGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQS 290

  Fly   814 NAEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRL 878
            .  |||..|:.|..|||.||||:|||:::|.|.:: :||                    :.:..|
Mouse   291 G--QVISAPRSIGLHYLATWFFVDLIAALPFDLLY-VFN--------------------ITVTSL 332

  Fly   879 AKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASV 943
            ..||..||||||.||            ||.|::.|               ..|.::|..|
Mouse   333 VHLLKTVRLLRLLRL------------LQKLERYS---------------QCSAVVLTLL----- 365

  Fly   944 FMRIFNLICMMLLIGHWSGCLQFLV---------PMLQGFPSNSWVSI--NELQESY-------- 989
             |.:|      .|:.||..|:.:::         |:|...   .|:..  ..|:|.|
Mouse   366 -MSVF------ALLAHWMACVWYVIGRREMEANDPLLWDI---GWLHELGKRLEEPYVNGSAGGP 420

  Fly   990 -WLEQYSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSR 1053
             ....|..||:..:|.:..:|:|.....:..:...::.:|:.||..:|:..|:.|.:||.:.|.|
Mouse   421 SRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRR 485

  Fly  1054 RQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRYQ-GKFFDEELILGELSEKLREDVINYNCRS 1117
            ..|..::|.:::::...:|||.::||:.|||:..:. ....|...:|.:..::||.|:..:..|.
Mouse   486 SLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNRE 550

  Fly  1118 LVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVA--- 1179
            :: .:|.|..|....:..:...:|.....||:.:::.|......|::..|.::::..|..:|
Mouse   551 IL-QLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILG 614

  Fly  1180 -----------TSLSDGSYFGEICLLTNARRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTM 1233
                       .....||..|..|:|..:   |.|:|.|||.|..||......||..||
Mouse   615 KGDLIGADIPELGQEPGSGAGPSCVLKTS---ADVKALTYCGLQQLSSRGLAEVLRLYP------ 670

  Fly  1234 ETVAAER-------------------LNKIGKNPNIMHQKDEQLSNPESNTITAV 1269
            |..||.|                   |.:..::|.:...:.:.|.:....|:.::
Mouse   671 EYAAAFRAGLPRDLTFNLRQGSENNGLGRFSRSPRLSQARSDTLGSSSDKTLPSI 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:400630	6/41 (15%)
		PLN03192	741..>1214	CDD:215625	123/511 (24%)
Kcnh4	NP_001074663.1	PRK13557	41..>134	CDD:237425
		PLN03192	177..>620	CDD:215625	121/524 (23%)
		cNMP_binding	578..667	CDD:459637	22/91 (24%)
		PHA03247	<712..1003	CDD:223021	2/14 (14%)