DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ih and KCNH2

DIOPT Version :9

Sequence 1:NP_001033948.1 Gene:Ih / 36589 FlyBaseID:FBgn0263397 Length:1327 Species:Drosophila melanogaster
Sequence 2:NP_000229.1 Gene:KCNH2 / 3757 HGNCID:6251 Length:1159 Species:Homo sapiens


Alignment Length:1000 Identity:222/1000 - (22%)
Similarity:343/1000 - (34%) Gaps:357/1000 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   305 LNLYLVEKKHSLQPQVASTSSSINTTHPQAS-SAPASSSSTCTKAPQLPALSAVAARQQQLLLNG 368
            ||..:|.:|    ..|.|.:...|...|..| .||..:.:...|   ||||.|:.||:       
Human   127 LNFEVVMEK----DMVGSPAHDTNHRGPPTSWLAPGRAKTFRLK---LPALLALTARE------- 177

  Fly   369 SLKGKGQSQSQGQSRQTLPGHRASVRSESGSGSSHTIPATGKSPPVPHSLAAKISSSASGSKNCN 433
                                  :|||| .|:|        |...|....:...::.:|..|::..
Human   178 ----------------------SSVRS-GGAG--------GAGAPGAVVVDVDLTPAAPSSESLA 211

  Fly   434 L--LSASSNSCHKLNAHAQGSG--------AGSGSGSGSGSG----PPGHSHYAAASPKSSVSSN 484
            |  ::|..|       |..|.|        .|.||...|..|    |..||    .:|.:|.|| 
Human   212 LDEVTAMDN-------HVAGLGPAEERRALVGPGSPPRSAPGQLPSPRAHS----LNPDASGSS- 264

  Fly   485 GHLNKYCLTDLTRRKAEFNRQLSAPTDYTHHSSSNGSQQEGSSEANEGHEPVGESTITVASAGVS 549
                  |....||.:                 .|..|.:..||          ...|....|||.
Human   265 ------CSLARTRSR-----------------ESCASVRRASS----------ADDIEAMRAGVL 296

  Fly   550 YPHPYSYPYHYAHHASSATAPANLKASLQLHSFGSHHPCPYPARPTSTSCTNSFNRRHIRRHKGK 614
            .|.|        .|||:                |:.||                           
Human   297 PPPP--------RHAST----------------GAMHP--------------------------- 310

  Fly   615 LGDRLLSGDSEESVRCSYCSVLNVNDNDLRISFENTCTDSLVTAFDDEALLICDQGTEMVHFDDV 679
                                        ||....|:.:||                       |:
Human   311 ----------------------------LRSGLLNSTSDS-----------------------DL 324

  Fly   680 SLYGTPKEEPMPNIPIVSEKVSANFLKSQLQSWFQPTDNR--LAMKLFGSRKALVKERIRQKTS- 741
            ..|.|..:.|...:..|..| ...||.|       ||.:|  :|.|: ..|...|.|::.|..| 
Human   325 VRYRTISKIPQITLNFVDLK-GDPFLAS-------PTSDREIIAPKI-KERTHNVTEKVTQVLSL 380

  Fly   742 ---------------GHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISFFNDDLSTRWIAFNC 791
                           ..|.|...|.|:..||..:|||::...:..|.:.:|...:......|..|
Human   381 GADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATEC 445

  Fly   792 ------------LSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISSIPL 844
                        :.|.:|::||::||||..:..:  |:|:..|..||.||.:.||.:|::::||.
Human   446 GYACQPLAVVDLIVDIMFIVDILINFRTTYVNAN--EEVVSHPGRIAVHYFKGWFLIDMVAAIPF 508

  Fly   845 DYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQNL 909
            |  .|||.        |.|.:::            .||...|||||.|:.|.:.::.|.      
Human   509 D--LLIFG--------SGSEELI------------GLLKTARLLRLVRVARKLDRYSEY------ 545

  Fly   910 QKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGF 974
                                          .|:|   :|.|:|...||.||..|:          
Human   546 ------------------------------GAAV---LFLLMCTFALIAHWLACI---------- 567

  Fly   975 PSNSWVSINELQESY------WL----------------------EQYSWALFKAMSHMLCIGYG 1011
                |.:|..:::.:      ||                      ::|..||:...|.:..:|:|
Human   568 ----WYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFG 628

  Fly  1012 RFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDM 1076
            ...|.:.::...::..|:.|:..||...|:.:.:||.|.|...:|..::.:|.|::.:.::|..:
Human   629 NVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPL 693

  Fly  1077 RQRITEYFEHRYQ-GKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKL 1140
            |||:.|||:|.:. ....|...:|....|.|:.|:..:..|||:.....|..|....:..:..|.
Human   694 RQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKF 758

  Fly  1141 KYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATS-LSDGSYFGEICLL--TNARRVAS 1202
            |.....|||.::..|.:.|.:|||..|.::|:  .|:|..: |.....|||...|  ...:....
Human   759 KTTHAPPGDTLVHAGDLLTALYFISRGSIEIL--RGDVVVAILGKNDIFGEPLNLYARPGKSNGD 821

  Fly  1203 VRAETYCNLFSLSVDHFNCVLDQYP 1227
            |||.|||:|..:..|....|||.||
Human   822 VRALTYCDLHKIHRDDLLEVLDMYP 846

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IhNP_001033948.1 Ion_trans_N 709..751 CDD:285597 12/59 (20%)
Ion_trans 771..1054 CDD:278921 70/322 (22%)
Crp 1118..>1241 CDD:223736 34/112 (30%)
CAP_ED 1124..1233 CDD:237999 33/106 (31%)
KCNH2NP_000229.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..314 33/199 (17%)
Ion_trans 409..668 CDD:306908 74/335 (22%)
Selectivity filter. /evidence=ECO:0000250 624..629 1/4 (25%)
CAP_ED 742..853 CDD:237999 33/106 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 870..982
SSTK-IP 1012..1113 CDD:318128
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1015..1038
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1119..1159
PAS_9 29..130 CDD:315989 2/2 (100%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0498
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.