DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ih and KCNH1

DIOPT Version :10

Sequence 1:NP_001033948.1 Gene:Ih / 36589 FlyBaseID:FBgn0263397 Length:1327 Species:Drosophila melanogaster
Sequence 2:NP_758872.1 Gene:KCNH1 / 3756 HGNCID:6250 Length:989 Species:Homo sapiens


Alignment Length:815 Identity:190/815 - (23%)
Similarity:320/815 - (39%) Gaps:164/815 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   620 LSG--DSEESVRCSYCSVL--NVNDND----LRISFENTCTDSL-----------VTAF------ 659
            |||  .:|...:.|.||.:  .:.|.|    :|.:|||...:|.           |..|      
Human    52 LSGYHRAEVMQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPI 116

  Fly   660 ----DDEALLICDQGTEMVHFDDVSLYGTPKEEPMPN-----IPIVSEKVSANFLKSQLQSWFQP 715
                |...|.:|.       |.|::.:..|.|:....     ..:.....|:..:..||....|.
Human   117 RNEQDKVVLFLCT-------FSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQK 174

  Fly   716 TDN-----RLAMKL-FGSRKALVKERIRQKTSGHWVIHPCSSFRFYWDLCMLLLLVANLIILPVA 774
            .:|     |||..| .||......::...||..|.::|.| .|:..||..:|:|.....|::|..
Human   175 GENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYC-VFKTTWDWIILILTFYTAILVPYN 238

  Fly   775 ISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLI 839
            :||.....:..|:..:.:.|.|||:|||:||.|..:  ..|.:||.|||||..:||:|||.:||:
Human   239 VSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFV--GPAGEVISDPKLIRMNYLKTWFVIDLL 301

  Fly   840 SSIPLDYIFLIFNQIMKLQDF-SDSFQI---------LHAGRALRILRLAKLLSLVRLLRLSRLV 894
            |.:|.| :...|..:.::..| .|..:|         |....:..|..|...|.:||||||.|:.
Human   302 SCLPYD-VINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVA 365

  Fly   895 R----YVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMML 955
            |    |:.....|.:|                                           |:|:..
Human   366 RKLDHYIEYGAAVLVL-------------------------------------------LVCVFG 387

  Fly   956 LIGHWSGCLQFLVPMLQGFP-------SNSWV-----------SINELQESYW------LEQYSW 996
            |..||..|:.:.:...:.|.       :|||:           ..|......|      ...|..
Human   388 LAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYIS 452

  Fly   997 ALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVK 1061
            :|:..|:.:..:|:|...|.:..:....:..|:.|:..||...|:.|.:.|.:.::..:|.|.:.
Human   453 SLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLN 517

  Fly  1062 QVEEYMAYRKLPRDMRQRITEYFEHRY-QGKFFDEELILGELSEKLREDVINYNCRSLVASVPFF 1125
            .|.:::...::|:.:.:|:.:|....: ..:..|.|.:|....:.:|.|:..:..|.:....|.|
Human   518 SVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAF 582

  Fly  1126 ANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYFGE 1190
            ..|....:..:..:.:.....|||:|...|.....:.|:..|.::::. :.||...|..|..||:
Human   583 RLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQ-DDEVVAILGKGDVFGD 646

  Fly  1191 ICL--LTNARRVASVRAETYCNLFSLSVDHFNCVLDQY-----PLMRKTMETVAAERLNKIGKNP 1248
            :..  .|.|:..|:|||.|||:|..:..|....||:.|     ...|..:.|....:.....|..
Human   647 VFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKIS 711

  Fly  1249 NIMHQKDEQLSN--------PESNTITAVVN--------ALAAEADDCKDDDMDL-KENLL--HG 1294
            ::..:::|::..        |..:.:..:..        .||||......||:|: |.|:|  |.
Human   712 DVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHA 776

  Fly  1295 S--ESSIAEPVQTIREGLPRPRSGEFRALFEGNTP 1327
            |  .|.:...|.|:||....|.|  |:|......|
Human   777 SANHSLVKASVVTVRESPATPVS--FQAASTSGVP 809

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IhNP_001033948.1 Ion_trans_N 709..751 CDD:400630 14/47 (30%)
PLN03192 741..>1214 CDD:215625 123/513 (24%)
KCNH1NP_758872.1 PAS_9 41..135 CDD:463873 21/89 (24%)
Required for phosphatidylinositol bisphosphate binding. /evidence=ECO:0000269|PubMed:27005320 151..162 1/10 (10%)
PLN03192 220..>647 CDD:215625 109/473 (23%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:Q63472 463..468 1/4 (25%)
PRK11753 608..>712 CDD:236969 27/104 (26%)
Calmodulin-binding. /evidence=ECO:0000269|PubMed:10880439 673..770 17/96 (18%)
Interaction with cyclic nucleotide-binding pocket. /evidence=ECO:0000250|UniProtKB:Q60603 699..701 0/1 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 855..886
CAD (involved in subunit assembly). /evidence=ECO:0000250|UniProtKB:Q63472 924..964
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 962..989
Blue background indicates that the domain is not in the aligned region.

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