DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ih and CngA

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster

Alignment Length:	827	Identity:	185/827 - (22%)
Similarity:	323/827 - (39%)	Gaps:	196/827 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   503 NRQLSAPTDYTHHSSSNGSQQE---GSSEANEGHEP--------------VGESTITVASAGVSY 550
            ||.:...|.....:||..:|.:   ||.:|..|..|              ...:||||..|..|.
  Fly    37 NRPMYRTTRLVGPASSAPAQLQLPCGSHQATLGVAPPPLEEISGGLFAPFAPTATITVEQAATSI 101

  Fly   551 PHPYSYPYHYAHHASSATAPANLKASLQLHSFGSHHPCPYPARPTSTSCTNSFNRRH---IRRHK 612
            |.......|:.|                           ||.|        |:.|::   |.|..
  Fly   102 PMAVDGEVHHLH---------------------------YPRR--------SWQRKYRQGIHRQP 131

  Fly   613 GKLGDRLLSGDSEESVRCSYCSVLNVNDNDLRISFENTCTDSLVTAFDDEALLICDQGTEMVHFD 677
            |  |......|.||...       :|:::|......:.|.|:     .:||:...|..|:.
  Fly   132 G--GGAEQDEDEEEDDD-------DVDEDDDDEFGASVCEDN-----PEEAIARADHDTQQ---- 178

  Fly   678 DVSLYGTPKEEPMPN-------------IPIVSEKVSANFLKSQLQS---------------W-- 712
                    |:...||             |...|::...:.|:..||:               |
  Fly   179 --------KQHYQPNASDSSYVENGRKLIQEPSKRSKPSALRRTLQALRQRLTKRNRPKPPDWFL 235

  Fly   713 --FQPTDN--RLAMKLFGSRKALVKERIRQKT--SGHWVIHPCSSFRFYWDLCMLLLLVANLIIL 771
              |..|.|  ::.........|.:...||..:  .....:.|.....:.| |.::.|.|...||.
  Fly   236 EKFSNTTNTDKIGKGCPAMEDAALSSEIRGSSVLCNRLSVDPTLQSHYRW-LAIVSLAVLYNIIF 299

  Fly   772 PVAISFF---NDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRT- 832
            .|..:.|   |......|...:.|.|.|:|:|.:|:...|.:.|.   .::.|...:.:||..|
  Fly   300 VVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFLDQG---LLVRDAFRLRRHYFHTK 361

  Fly   833 -WFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRY 896
             | :||::|.:|.|..::.:.        .::...|:       |....::.|.||||::||
  Fly   362 GW-YLDVLSMLPTDLAYIWWP--------PETCSSLY-------LPCPVIVRLNRLLRINRL--- 407

  Fly   897 VSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWS 961
               ||..       .::....|..|.                      .||..::..:|::.||:
  Fly   408 ---WEWF-------DRTETATGYPNA----------------------FRICKVVLAILVLIHWN 440

  Fly   962 GCLQFLVPMLQGFPSNSWV-SINELQESYWLEQYSWALFKAMSHMLCIGYGRFP-PQSLTDMWLT 1024
            .|:.|.:....||.|:||| ::|..:.:....||.::.:  .|.:.....|..| |::..:....
  Fly   441 ACMYFAISYEIGFSSDSWVYNLNGTRNNTLQRQYIYSFY--WSTLTLTTIGETPTPENDVEYLFV 503

  Fly  1025 MLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRY- 1088
            :...::|...:|..:|:..::|.:::.:|.:::.::..|::|||:|::..::..|:..:|.:.:
  Fly   504 VADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWS 568

  Fly  1089 QGKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIK 1153
            |....|||.:|..|.:||:.::........:..|..|.:.:...:..:|.|||.:||.|||.|.:
  Fly   569 QSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICR 633

  Fly  1154 EGTIGTKMYFIQEGVVDIVMANG-EVATSLSDGSYFGEICLL------TNARRVASVRAETYCNL 1211
            :|.:|.:||.::.|.:.:|..:| .|..:|..||.|||:.:|      |..||.|:||:..|.:|
  Fly   634 KGDVGKEMYIVKRGKLSVVGDDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDL 698

  Fly  1212 FSLSVDHFNCVLDQYPLMRKTMETVAAERLNKIGKNPNIMHQKDEQL 1258
            |.|:.......|..||..|.|:.....:.|.|.|       ..|||:
  Fly   699 FCLAKRDLWETLSDYPEARSTLTQRGCQLLRKDG-------LLDEQI 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	10/64 (16%)
		Ion_trans	771..1054	CDD:278921	59/289 (20%)
		Crp	1118..>1241	CDD:223736	42/129 (33%)
		CAP_ED	1124..1233	CDD:237999	40/115 (35%)
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	57/275 (21%)
		Ion_trans_2	<477..527	CDD:285168	8/51 (16%)
		Crp	598..>722	CDD:223736	42/123 (34%)
		CAP_ED	604..717	CDD:237999	39/112 (35%)
		CLZ	720..791	CDD:293134	6/26 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445383
Domainoid	1	1.000	45	1.000	Domainoid score	I4624
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm987
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850