DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ih and HCN1

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_066550.2	Gene:	HCN1 / 348980	HGNCID:	4845	Length:	890	Species:	Homo sapiens

Alignment Length:	573	Identity:	315/573 - (54%)
Similarity:	424/573 - (73%)	Gaps:	45/573 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   704 FLKSQLQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSSFRFYWDLCMLLLLVANL 768
            |::.|..|..||..|:.::::|||:||:.||:.|.||:|.|:|||.|.|||||||.||:::|.||
Human    93 FMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNL 157

  Fly   769 IILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTW 833
            :|:||.|:||.:..:|.||.||..|||:||:|:::|||||.:.:|::| :|||||:|..:||::|
Human   158 VIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSE-IILDPKVIKMNYLKSW 221

  Fly   834 FFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVS 898
            |.:|.|||||:||||||..:.|      || ::....|||||:|..|:|||:||||||||:||:.
Human   222 FVVDFISSIPVDYIFLIVEKGM------DS-EVYKTARALRIVRFTKILSLLRLLRLSRLIRYIH 279

  Fly   899 QWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGC 963
            ||||::.:.                              .::||..:||||||.||||:.||.||
Human   280 QWEEIFHMT------------------------------YDLASAVVRIFNLIGMMLLLCHWDGC 314

  Fly   964 LQFLVPMLQGFPSNSWVSINELQESYWLEQYSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSM 1028
            ||||||:||.||.:.|||:||:....|.:|||:|||||||||||||||...|.|::|:|:|||||
Human   315 LQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSM 379

  Fly  1029 ISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRYQGKFF 1093
            |.||||||:|:||||.||||||||||||:||.||||:||::.|||.||||:|.:|:|||||||.|
Human   380 IVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIF 444

  Fly  1094 DEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIG 1158
            |||.||.||::.|||:::|:|||.|||::|.|||||.|||:.:::||::|||||||.||:||.:|
Human   445 DEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVG 509

  Fly  1159 TKMYFIQEGVVDIVMANGEVATSLSDGSYFGEICLLTNARRVASVRAETYCNLFSLSVDHFNCVL 1223
            .||||||.||..::..:.: ...|:||||||||||||..||.|||||:|||.|:|||||:||.||
Human   510 KKMYFIQHGVAGVITKSSK-EMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVL 573

  Fly  1224 DQYPLMRKTMETVAAERLNKIGKNPNIMHQKDEQ------LSNPESNTITAVV 1270
            ::||:||:..||||.:||::|||..:|:.||.::      .:|.|:..:..:|
Human   574 EEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIV 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	19/41 (46%)
		Ion_trans	771..1054	CDD:278921	151/282 (54%)
		Crp	1118..>1241	CDD:223736	75/122 (61%)
		CAP_ED	1124..1233	CDD:237999	67/108 (62%)
HCN1	NP_066550.2	Disordered. /evidence=ECO:0000305\|PubMed:28086084	1..93		315/573 (55%)
		Ion_trans_N	98..140	CDD:285597	19/41 (46%)
		Ion_trans	160..405	CDD:278921	151/282 (54%)
		Selectivity filter. /evidence=ECO:0000305\|PubMed:28086084	358..362		3/3 (100%)
		Crp	469..>604	CDD:223736	81/135 (60%)
		CAP_ED	475..583	CDD:237999	67/108 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	644..692
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	725..796
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	845..890
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	178	1.000	Domainoid score	I3565
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000897
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101339
Panther	1	1.100	-	-	O	PTHR45689
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X717
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.810