DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ih and Cngb1

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_001182342.1	Gene:	Cngb1 / 333329	MGIID:	2664102	Length:	1325	Species:	Mus musculus

Alignment Length:	705	Identity:	163/705 - (23%)
Similarity:	280/705 - (39%)	Gaps:	190/705 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   685 PKEEPMPNIPIVSEKVS-------------------ANFLK------SQLQSWFQPT-------- 716
            |.|.|.|: |:.|:.::                   |..||      |.:.:|..||
Mouse   563 PPERPPPS-PVKSDTLTVPGAAAAGHRKKLPSQDDEAEELKALSPAESPVVAWSDPTTPQEADGQ 626

  Fly   717 --------------DNRL--AMKLFGSRKALVKERI-------------------------RQKT 740
                          ::||  .:|:|..|...|||::                         .||.
Mouse   627 DRAASTASQNSAIINDRLQELVKMFKERTEKVKEKLIDPDVTSDEESPKPSPAKKAPEPDPAQKP 691

  Fly   741 S-------GHWVIHPCSSFR---------------------FYWDLCMLLLLVANLIILPV--AI 775
            :       .|:....|..|:                     ..|...::|....|..::||  |.
Mouse   692 AEAEVAEEEHYCDMLCCKFKRRPLKMYRFPQSIDPLTNLMYILWLFFVVLAWNWNCWLIPVRWAF 756

  Fly   776 SFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRT-WFFLDLI 839
            .:...|....|:..:.|.|.|:|:||.| |:.. :|......:|.|.|.:..:||:: .|.:||:
Mouse   757 PYQRADNIHFWLLMDYLCDFIYLLDITV-FQMR-LQFVKGGDIITDKKEMRNNYLKSRRFKMDLL 819

  Fly   840 SSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVY 904
            ..:|||:::|                               .|.:..||||.|.::|::.:|
Mouse   820 CLLPLDFLYL-------------------------------KLGINPLLRLPRCLKYMAFFE--- 850

  Fly   905 ILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVP 969
                                     .:|.:...|:.|.|: |:......:|...|.:.||.:...
Mouse   851 -------------------------FNNRLEAILSKAYVY-RVIRTTAYLLYSLHLNSCLYYWAS 889

  Fly   970 MLQGFPSNSWVSINELQESYWLEQYSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATC 1034
            ..||..|..|| .:.:..|| :..|.|    |:..::.|| |...||:|.::...:|:..:|...
Mouse   890 AFQGIGSTHWV-YDGVGNSY-IRCYYW----AVKTLITIG-GLPDPQTLFEIVFQLLNYFTGVFA 947

  Fly  1035 YALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRYQGK-FFDEELI 1098
            :::.:|...:::.:..:.:..||..:....:||.:.|:||.::.|:..::|:.:..: ..||..:
Mouse   948 FSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPRSVQNRVKTWYEYTWHSQGMLDESEL 1012

  Fly  1099 LGELSEKLREDV---INYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTK 1160
            :.:|.:|:|.|:   :||   |:|:.|..|...|...:.|::.:|:..|:.|.|.:.|:|.||.:
Mouse  1013 MVQLPDKMRLDLAIDVNY---SIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGRE 1074

  Fly  1161 MYFIQEGVVDIVMA-NGE-VATSLSDGSYFGEICLLT---NARRVASVRAETYCNLFSLSVDHFN 1220
            ||.||.|.|.::.. :|: |..:|..||.||||.||.   ..||.|:|.|..:.|||.|.....|
Mouse  1075 MYIIQAGQVQVLGGPDGKAVLVTLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLN 1139

  Fly  1221 CVLDQYPLMRKTMETVAAERLNKIGKNPNIMHQKDEQLSNPESNTITAVVNALAA 1275
            .:|..||..:|.:...|...|.   .|.....:|...:..|.:.|......||||
Mouse  1140 EILVHYPESQKLLRKKARRMLR---NNNKPKEEKSVLILPPRAGTPKLFNAALAA 1191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	15/97 (15%)
		Ion_trans	771..1054	CDD:278921	62/285 (22%)
		Crp	1118..>1241	CDD:223736	45/127 (35%)
		CAP_ED	1124..1233	CDD:237999	42/113 (37%)
Cngb1	NP_001182342.1	Ion_trans	756..957	CDD:278921	59/269 (22%)
		Crp	1032..>1165	CDD:223736	47/135 (35%)
		CAP_ED	1038..1147	CDD:237999	40/108 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920