Protein Alignment Ih and Hcn4

DIOPT Version :10

• Sequence 1: NP_001033948.1
• Gene: Ih / 36589
• FlyBaseID: FBgn0263397
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: NP_001074661.1
• Gene: Hcn4 / 330953
• MGIID: 1298209
• Length: 1201
• Species: Mus musculus
• Alignment Length: 986
• Identity: 397/986 - (40%)
• Similarity: 518/986 - (52%)
• Gaps: 231/986 - (23%)

  Fly   338 PASSSSTCTKAPQLPALSAVAARQQQLLLNGSLKGKG--QSQSQGQSR-QTLPGHRASVRSESGS 399
            |.|........||.....|....:::   :|..:|.|  |..|:...| :.||....||.:....
Mouse     5 PPSMRKRLYSLPQQVGAKAWIMDEEE---DGEEEGAGGRQDPSRRSIRLRPLPSPSPSVAAGCSE 66

  Fly   400 GSSHTIPATGKSPPVPHSLAAKISSSASGSKNCNLLSASSNSCHKLNAHAQGSGAGSGSGSGSGS 464
            .....:.||....|           ..|..|     |:::..|.:........|:..|...|:|.
Mouse    67 SRGAALGATESEGP-----------GRSAGK-----SSTNGDCRRFRGSLASLGSRGGGSGGAGG 115

  Fly   465 GPPGHSHYAAASPKSSVSSNGHLNKYCLTDLTRRKAEFNRQLSAPTDYTHHSSSNGSQQEGSSEA 529
            |                ||.|||:.         .||..|.::|               ||.:..
Mouse   116 G----------------SSLGHLHD---------SAEERRLIAA---------------EGDASP 140

  Fly   530 NEGHEPVGESTITVASAGVSYPHPYSYPYHYAHHASSATAPANLKASLQLHSFGSHHPCPYPARP 594
            .|...|.|.:|               .|...|..|..|.:|                |...|.:|
Mouse   141 GEDRTPPGLAT---------------EPERPATAAQPAASP----------------PPQQPPQP 174

  Fly   595 TSTSCTNSFNRRHIRRHKG-KLGDRLLSGDSEESVRCSYCSVLNVNDNDLRISFENTCTDSLVTA 658
            .|.||........|:...| ...|::|   .|..||..
Mouse   175 ASASCEQPSADTAIKVEGGAAASDQIL---PEAEVRLG--------------------------- 209

  Fly   659 FDDEALLICDQGTEMVHFDDVSLYGTPKEEPMPNIPIVSEKVSANFLKSQLQSWFQPTDNRLAMK 723
                                                      .:.|::.|..:..||..|:.:::
Mouse   210 ------------------------------------------QSGFMQRQFGAMLQPGVNKFSLR 232

  Fly   724 LFGSRKALVKERIRQKTSGHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISFFNDDLSTRWIA 788
            :|||:||:.:|:.|.|::|.|:|||.|.|||||||.||||:|.||||:||.|:||.|:.:|.||.
Mouse   233 MFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIV 297

  Fly   789 FNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQ 853
            ||.:|||.||||:|:||||||:.:||.| :||||:.|...||::||.:|.|||||:||||||
Mouse   298 FNVVSDTFFLIDLVLNFRTGIVVEDNTE-IILDPQRIKMKYLKSWFVVDFISSIPVDYIFLI--- 358

  Fly   854 IMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRG 918
               ::...|| ::....|||||:|..|:|||:||||||||:||:.||||::.:.
Mouse   359 ---VETRIDS-EVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMT----------- 408

  Fly   919 RMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSIN 983
                               .::||..:||.|||.||||:.||.|||||||||||.||.:.|||||
Mouse   409 -------------------YDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPHDCWVSIN 454

  Fly   984 ELQESYWLEQYSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQS 1048
            .:..:.|.:|||:||||||||||||||||..|..::|:||||||||.||||||:|:||||.||||
Mouse   455 GMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQS 519

  Fly  1049 LDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRYQGKFFDEELILGELSEKLREDVINY 1113
            ||||||||:||.||||:||::.|||.|.||||.:|:|||||||.||||.|||||||.|||::||:
Mouse   520 LDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINF 584

  Fly  1114 NCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEV 1178
            |||.||||:|.|||||.|||:.::|||::|||||||.||:|||||.||||||.|||. |:..|..
Mouse   585 NCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVS-VLTKGNK 648

  Fly  1179 ATSLSDGSYFGEICLLTNARRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAERLNK 1243
            .|.|:||||||||||||..||.|||||:|||.|:|||||:||.||::||:||:..||||.:||::
Mouse   649 ETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDR 713

  Fly  1244 IGKNPNIM-----HQKDEQLSNPESNTITAVVNALAAEADDCKDDDMDLKENLLHGSE-SSIAEP 1302
            |||..:|:     |..:..:.|.:.|.|                    :::.:.|..| :..|..
Mouse   714 IGKKNSILLHKVQHDLNSGVFNYQENEI--------------------IQQIVRHDREMAHCAHR 758

  Fly  1303 VQTIREGLPRP 1313
            ||......|.|
Mouse   759 VQAAASATPTP 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:400630	16/41 (39%)
		PLN03192	741..>1214	CDD:215625	290/472 (61%)
Hcn4	NP_001074661.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..183		48/248 (19%)
		Involved in subunit assembly. /evidence=ECO:0000250	209..260		18/119 (15%)
		Ion_trans_N	218..260	CDD:400630	16/41 (39%)
		PLN03192	253..>740	CDD:215625	314/525 (60%)
		CAP_ED	595..703	CDD:237999	74/108 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	804..902
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	914..1201