DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ih and Hcn4

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_001074661.1	Gene:	Hcn4 / 330953	MGIID:	1298209	Length:	1201	Species:	Mus musculus

Alignment Length:	986	Identity:	397/986 - (40%)
Similarity:	518/986 - (52%)	Gaps:	231/986 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 PASSSSTCTKAPQLPALSAVAARQQQLLLNGSLKGKG--QSQSQGQSR-QTLPGHRASVRSESGS 399
            |.|........||.....|....:::   :|..:|.|  |..|:...| :.||....||.:....
Mouse     5 PPSMRKRLYSLPQQVGAKAWIMDEEE---DGEEEGAGGRQDPSRRSIRLRPLPSPSPSVAAGCSE 66

  Fly   400 GSSHTIPATGKSPPVPHSLAAKISSSASGSKNCNLLSASSNSCHKLNAHAQGSGAGSGSGSGSGS 464
            .....:.||....|           ..|..|     |:::..|.:........|:..|...|:|.
Mouse    67 SRGAALGATESEGP-----------GRSAGK-----SSTNGDCRRFRGSLASLGSRGGGSGGAGG 115

  Fly   465 GPPGHSHYAAASPKSSVSSNGHLNKYCLTDLTRRKAEFNRQLSAPTDYTHHSSSNGSQQEGSSEA 529
            |                ||.|||:.         .||..|.::|               ||.:..
Mouse   116 G----------------SSLGHLHD---------SAEERRLIAA---------------EGDASP 140

  Fly   530 NEGHEPVGESTITVASAGVSYPHPYSYPYHYAHHASSATAPANLKASLQLHSFGSHHPCPYPARP 594
            .|...|.|.:|               .|...|..|..|.:|                |...|.:|
Mouse   141 GEDRTPPGLAT---------------EPERPATAAQPAASP----------------PPQQPPQP 174

  Fly   595 TSTSCTNSFNRRHIRRHKG-KLGDRLLSGDSEESVRCSYCSVLNVNDNDLRISFENTCTDSLVTA 658
            .|.||........|:...| ...|::|   .|..||..
Mouse   175 ASASCEQPSADTAIKVEGGAAASDQIL---PEAEVRLG--------------------------- 209

  Fly   659 FDDEALLICDQGTEMVHFDDVSLYGTPKEEPMPNIPIVSEKVSANFLKSQLQSWFQPTDNRLAMK 723
                                                      .:.|::.|..:..||..|:.:::
Mouse   210 ------------------------------------------QSGFMQRQFGAMLQPGVNKFSLR 232

  Fly   724 LFGSRKALVKERIRQKTSGHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISFFNDDLSTRWIA 788
            :|||:||:.:|:.|.|::|.|:|||.|.|||||||.||||:|.||||:||.|:||.|:.:|.||.
Mouse   233 MFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIV 297

  Fly   789 FNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQ 853
            ||.:|||.||||:|:||||||:.:||.| :||||:.|...||::||.:|.|||||:||||||
Mouse   298 FNVVSDTFFLIDLVLNFRTGIVVEDNTE-IILDPQRIKMKYLKSWFVVDFISSIPVDYIFLI--- 358

  Fly   854 IMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRG 918
               ::...|| ::....|||||:|..|:|||:||||||||:||:.||||::.:.
Mouse   359 ---VETRIDS-EVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMT----------- 408

  Fly   919 RMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSIN 983
                               .::||..:||.|||.||||:.||.|||||||||||.||.:.|||||
Mouse   409 -------------------YDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPHDCWVSIN 454

  Fly   984 ELQESYWLEQYSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQS 1048
            .:..:.|.:|||:||||||||||||||||..|..::|:||||||||.||||||:|:||||.||||
Mouse   455 GMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQS 519

  Fly  1049 LDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRYQGKFFDEELILGELSEKLREDVINY 1113
            ||||||||:||.||||:||::.|||.|.||||.:|:|||||||.||||.|||||||.|||::||:
Mouse   520 LDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINF 584

  Fly  1114 NCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEV 1178
            |||.||||:|.|||||.|||:.::|||::|||||||.||:|||||.||||||.|||. |:..|..
Mouse   585 NCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVS-VLTKGNK 648

  Fly  1179 ATSLSDGSYFGEICLLTNARRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAERLNK 1243
            .|.|:||||||||||||..||.|||||:|||.|:|||||:||.||::||:||:..||||.:||::
Mouse   649 ETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDR 713

  Fly  1244 IGKNPNIM-----HQKDEQLSNPESNTITAVVNALAAEADDCKDDDMDLKENLLHGSE-SSIAEP 1302
            |||..:|:     |..:..:.|.:.|.|                    :::.:.|..| :..|..
Mouse   714 IGKKNSILLHKVQHDLNSGVFNYQENEI--------------------IQQIVRHDREMAHCAHR 758

  Fly  1303 VQTIREGLPRP 1313
            ||......|.|
Mouse   759 VQAAASATPTP 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	16/41 (39%)
		Ion_trans	771..1054	CDD:278921	155/282 (55%)
		Crp	1118..>1241	CDD:223736	83/122 (68%)
		CAP_ED	1124..1233	CDD:237999	74/108 (69%)
Hcn4	NP_001074661.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..121		24/130 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	135..183		17/78 (22%)
		Involved in subunit assembly. /evidence=ECO:0000250	209..260		18/119 (15%)
		Ion_trans_N	218..260	CDD:285597	16/41 (39%)
		Ion_trans	280..525	CDD:278921	155/282 (55%)
		Crp	589..>724	CDD:223736	89/135 (66%)
		CAP_ED	595..703	CDD:237999	74/108 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	804..902
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	914..1201
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	176	1.000	Domainoid score	I3586
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000897
OrthoInspector	1	1.000	-	-		otm44108
orthoMCL	1	0.900	-	-		OOG6_101339
Panther	1	1.100	-	-	O	PTHR45689
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8291
SonicParanoid	1	1.000	-	-		X717
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.840