DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ih and Cngl

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster

Alignment Length:	862	Identity:	191/862 - (22%)
Similarity:	338/862 - (39%)	Gaps:	222/862 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   421 KISSS---ASGSKNCNLLSASSNSCHKLNAHAQGSGAGSGSGSGSGSGPPGHSHYAAASPKSSVS 482
            |:|.|   |..|.:..:||:..:|  :||..:.|:.|.|.|.||           |.|:...::.
  Fly     2 KLSVSAYRAHASAHKKILSSGYHS--QLNYGSTGAAAASSSSSG-----------ATATGLYTME 53

  Fly   483 SNGHLNKYCLTDLTRRKAEFN--RQLSAP--TDYTHHSSSNGSQQEGSSEANEGHEPVGESTITV 543
            ::.|.....:.|:.|:..:.|  ..:.:|  |..:......|:...|.|....||...|
  Fly    54 AHEHEAGKFVKDVARQVHDCNSDTDVISPTGTSISGGGGGGGAGGAGGSGGAGGHSDGG------ 112

  Fly   544 ASAGVSYPHPYSYPYHYAHHASSATAPANLKASLQLHSFGSHHPCPYPARPTSTSCTNSFNRRHI 608
                          ||..||........|..|:   ||..|..|
  Fly   113 --------------YHKRHHHKMVRDDDNNSAA---HSSDSKSP--------------------- 139

  Fly   609 RRHKGKLGDRLLSGDSEESVRCSYCSVLNVNDNDLRISFENTCTDSLVTAFDDEALLICDQGTEM 673
            .:.|.::||.....||:.:           ..|...:....|
  Fly   140 SQRKSRIGDGASDPDSDWT-----------RSNQRWMKLRTT----------------------- 170

  Fly   674 VHFDDVSLYGTPKEEPMPNIPIVSEKVSANFLK-------SQLQSWFQPTDNRLAMKLFGSRKAL 731
                 |.:....:::|    |:..|.   :|||       .:.|...:.|.:..|.   |.....
  Fly   171 -----VQISSAIQKKP----PLKRED---SFLKRFSTRQIPETQETVEDTGSESAS---GDVDKS 220

  Fly   732 VKERIRQKTSGHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISF--FNDDLSTRWIAFNCLSD 794
            ||.|.|.......|::|..:|.|||.:.:.:.::.||..|.|..||  ....:.|.|:..:.::|
  Fly   221 VKRRRRYLQKRRSVVNPDENFYFYWLMMLTVCVLYNLWTLIVRQSFPELQQSVPTFWLICDSMTD 285

  Fly   795 TIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTW-FFLDLISSIPLDYIFLIFNQIMKLQ 858
            .:|::||:|..|||.::|.   .::.|.:.:|.||:.:. |..|:|:.||||.:.|...
  Fly   286 VVFILDIIVQLRTGYLEQG---LMVYDDRKLACHYVHSRDFIFDMIALIPLDLLQLKMG------ 341

  Fly   859 DFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRK 923
                    .|.     :||..:...:.|.:|...:|...:.|..::
  Fly   342 --------THP-----LLRFTRFFKVYRSVRFYYIVESRTVWPNLW------------------- 374

  Fly   924 DKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWV-------- 980
                                  |:.|||.::|::.||.||..||:...:|| ...||
  Fly   375 ----------------------RVVNLIHILLILAHWFGCFYFLLSEAEGF-QGDWVYPYRPGDY 416

  Fly   981 ---SINELQESYWLEQYSWALFKAMSHMLCIGYGRFP-PQSLTDMWLTMLSMISGATCYALFLGH 1041
               :...|...||            |.:.....|..| |::..:...|::|.:.|...:|..:|.
  Fly   417 ATLTRKYLGSLYW------------STLTLTTIGDLPTPETNAEYIFTIVSYLIGVFIFATIVGQ 469

  Fly  1042 ATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEH-----RYQGKFFDEELILGE 1101
            ..|:|.:.:::|.::...:...:.||.:.|:|..|::|:..::::     |.||. .|....||.
  Fly   470 VGNVITNRNANRLEFERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGG-GDINTALGL 533

  Fly  1102 LSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQE 1166
            |.:||:.::..:...|::..|..|......|:.|:|.|:|..:|.|||.|.::|.:..:|:.|.:
  Fly   534 LPDKLKTELALHVNLSVLKKVTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIAD 598

  Fly  1167 GVVDIVMANGEVATSLSDGSYFGEICLLT----NARRVASVRAETYCNLFSLSVDHFNCVLDQYP 1227
            |:::::...|:|.|::..|.:||||.:|.    | :|.|.||:..|..|||||.:.....:..||
  Fly   599 GILEVLSETGKVLTTMKAGDFFGEIGILNLDGLN-KRTADVRSVGYSELFSLSREDVLAAMKDYP 662

  Fly  1228 LMRKTMETVAAERLNKI 1244
            ..::.::|:..:||.::
  Fly   663 DAQEILQTLGRKRLMEV 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	10/41 (24%)
		Ion_trans	771..1054	CDD:278921	63/297 (21%)
		Crp	1118..>1241	CDD:223736	39/126 (31%)
		CAP_ED	1124..1233	CDD:237999	37/112 (33%)
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	63/296 (21%)
		Ion_trans_2	382..476	CDD:285168	25/106 (24%)
		Crp	550..>680	CDD:223736	41/131 (31%)
		CAP_ED	556..668	CDD:237999	37/112 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445388
Domainoid	1	1.000	45	1.000	Domainoid score	I4624
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2706
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850