DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ih and Kcnh3

DIOPT Version :10

Sequence 1:NP_001033948.1 Gene:Ih / 36589 FlyBaseID:FBgn0263397 Length:1327 Species:Drosophila melanogaster
Sequence 2:NP_058804.1 Gene:Kcnh3 / 27150 RGDID:71070 Length:1087 Species:Rattus norvegicus


Alignment Length:704 Identity:160/704 - (22%)
Similarity:270/704 - (38%) Gaps:189/704 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   705 LKSQLQSWFQPT-DNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSSFRFYWDLCMLL--LLVA 766
            |...||.  ||. .::|...:||.:..|.:.::.......:::..|.:.|..||..:||  |.||
  Rat   177 LSGHLQK--QPKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVA 239

  Fly   767 NLIILPVAISFFNDDLSTRWIAFNC--LSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHY 829
            ..:...|.:|...:..:.|.....|  ..:.:|::|||:||||..:.:..  ||:..||.|..||
  Rat   240 VTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSG--QVVFAPKSICLHY 302

  Fly   830 LRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLV 894
            :.|||.||:|:::|                    |.:|||.: :.:...|.||..||||||.||:
  Rat   303 VTTWFLLDVIAALP--------------------FDLLHAFK-VNVYVGAHLLKTVRLLRLLRLL 346

  Fly   895 ----RYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMML 955
                || ||:..|.:                                    ::.|.:|      .
  Rat   347 PRLDRY-SQYSAVVL------------------------------------TLLMAVF------A 368

  Fly   956 LIGHWSGCLQFLVPMLQGFPSNSWVSINELQESYWLEQ--------------------------- 993
            |:.||..|:.|.:...:...|.|     ||.|..||::                           
  Rat   369 LLAHWVACVWFYIGQQEIENSES-----ELPEIGWLQELARRLETPYYLVSRSPDGGNSSGQSEN 428

  Fly   994 --------------------------YSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGA 1032
                                      |..:|:.|:|.:..:|:|.....:.|:...::.:|:.||
  Rat   429 CSSSGGGSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGA 493

  Fly  1033 TCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRYQ-GKFFDEE 1096
            ..:|:..|:.|.:||.:.:.|..|..:.:.:.:|:...::|:.::||:.|||:..:. ....|..
  Rat   494 LMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTT 558

  Fly  1097 LILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKM 1161
            .:|..|.::||.| |..:....|..:|.|..|....:..:...|:.....||:.:|.:|.....:
  Rat   559 ELLQSLPDELRAD-IAMHLHKEVLQLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQAL 622

  Fly  1162 YFIQEGVVDIVMANGEVATSLSDGSYFGEICLLTNARRV----ASVRAETYCNLFSLSVDHFNCV 1222
            ||:..|.:: |:..|.|...|..|...|  |.|....:|    |.|:..|||.|..|.:...:..
  Rat   623 YFVCSGSME-VLKGGTVLAILGKGDLIG--CELPQREQVVKANADVKGLTYCVLQCLQLAGLHES 684

  Fly  1223 LDQYPLMRKTMET--------------VAAE--RLNKIGKNPNIMHQKDEQLSNPESNTITAVVN 1271
            |..||........              |:||  ..:..|.|..:...::::....:.:||:    
  Rat   685 LALYPEFAPRFSRGLRGELSYNLGAGGVSAEVDTSSLSGDNTLMSTLEEKETDGEQGHTIS---- 745

  Fly  1272 ALAAEADD---------CKDDDMDLKENLLHGSESSIAEPVQTIREGLPRPRSG 1316
              .|.||:         |              :.||.|..:.:.|...||||.|
  Rat   746 --PAPADEPSSPLLSPGC--------------TSSSSAAKLLSPRRTAPRPRLG 783

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IhNP_001033948.1 Ion_trans_N 709..751 CDD:400630 9/42 (21%)
PLN03192 741..>1214 CDD:215625 127/538 (24%)
Kcnh3NP_058804.1 PAS_9 40..135 CDD:463873
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 137..161
PLN03192 227..>654 CDD:215625 118/501 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 416..436 0/19 (0%)
Selectivity filter. /evidence=ECO:0000250 468..473 1/4 (25%)
cyc_nuc_ocin <609..704 CDD:274839 25/97 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 733..813 15/71 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 975..1061
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.