DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ih and Kcnh8

DIOPT Version :10

Sequence 1:NP_001033948.1 Gene:Ih / 36589 FlyBaseID:FBgn0263397 Length:1327 Species:Drosophila melanogaster
Sequence 2:NP_659563.1 Gene:Kcnh8 / 246325 RGDID:2549 Length:1102 Species:Rattus norvegicus


Alignment Length:666 Identity:150/666 - (22%)
Similarity:278/666 - (41%) Gaps:143/666 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   718 NRLAM--KLFGSRKALVKERIRQKTSGHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISFF-N 779
            |:|.:  .:|..:.|..:.::.......:::...|:|:..||..:||......:.:|..:.|. |
  Rat   184 NKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGN 248

  Fly   780 DDLSTRWIAFNCLSD----TIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLIS 840
            :||||  .....:||    .:|:|||::||||..:.:..  |||.:.:.|..||:.|||.:|||:
  Rat   249 EDLST--TRSTTVSDIAVEILFIIDIILNFRTTYVSKSG--QVIFEARSICIHYVTTWFIIDLIA 309

  Fly   841 SIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYI 905
            ::|.|.:: .||                    :.::.|..||..||||||.||            
  Rat   310 ALPFDLLY-AFN--------------------VTVVSLVHLLKTVRLLRLLRL------------ 341

  Fly   906 LQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPM 970
            ||.|.:.|               ..|.::|..            |:.|..|:.||..|:.:::..
  Rat   342 LQKLDRYS---------------QHSTIVLTL------------LMSMFALLAHWMACIWYVIGK 379

  Fly   971 LQGFPSNS---WVSINELQESYWLEQ-----------------------YSWALFKAMSHMLCIG 1009
            ::. ..||   |       |..||.:                       |..||:..:|.:..:|
  Rat   380 MER-EDNSLLKW-------EVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVG 436

  Fly  1010 YGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPR 1074
            :|.....:..:...::.:|:.||..:||..|:.|.:||.:.|....|..:.|.:::::....||:
  Rat   437 FGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQ 501

  Fly  1075 DMRQRITEYFEHRYQ-GKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVT 1138
            .::||:.|||:..:. ....|...:|.:..::||.| |..:....:..:..|..|....:..:..
  Rat   502 QLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSD-ITMHLNKEILQLSLFECASRGCLRSLSL 565

  Fly  1139 KLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYFG------EICLLTNA 1197
            .:|.....||:.::::|.....:||:..|.:: |:.:..|...|..|...|      :..:.|| 
  Rat   566 HIKTSFCAPGEYLLRQGDALQAIYFVCSGSME-VLKDSMVLAILGKGDLIGANLSIKDQVIKTN- 628

  Fly  1198 RRVASVRAETYCNLFSLSVDHFNCVLDQYP-LMRKTMETVAAERLNKIGKNPNIMHQKD--EQLS 1259
               |.|:|.|||:|..:.:.....||..|| ...|.:|.:..:....:.:.    |:.|  .:||
  Rat   629 ---ADVKALTYCDLQCIILKGLFEVLGLYPEYAHKFVEDIQHDLTYNLREG----HESDVISRLS 686

  Fly  1260 N--------PESNTITAVVNALAAEADDCKDDDMDLKENL----LHGSESSIAEPVQTIREGLPR 1312
            |        |:.|  .::...|.:..:|.::::::.:|..    ::...||::...:|   |..:
  Rat   687 NKSTVPQAEPKGN--GSIKKRLPSIVEDEEEEEVEEEETTSLSPIYTRGSSVSHSKKT---GSSK 746

  Fly  1313 PRSG-EFRALFEGNTP 1327
            ...| ..:.|..|..|
  Rat   747 SYLGLSLKQLTSGTVP 762

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IhNP_001033948.1 Ion_trans_N 709..751 CDD:400630 4/34 (12%)
PLN03192 741..>1214 CDD:215625 122/510 (24%)
Kcnh8NP_659563.1 PAS_9 40..135 CDD:463873
PLN03192 175..>615 CDD:215625 116/504 (23%)
Selectivity filter. /evidence=ECO:0000250 434..439 1/4 (25%)
cNMP-binding domain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00060 551..668 29/121 (24%)
PRK11753 578..>656 CDD:236969 21/82 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 683..744 11/65 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 762..793 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 818..845
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 960..983
Blue background indicates that the domain is not in the aligned region.

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