Protein Alignment Ih and Kcnh5

DIOPT Version :10

• Sequence 1: NP_001033948.1
• Gene: Ih / 36589
• FlyBaseID: FBgn0263397
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: NP_766393.2
• Gene: Kcnh5 / 238271
• MGIID: 3584508
• Length: 988
• Species: Mus musculus
• Alignment Length: 809
• Identity: 180/809 - (22%)
• Similarity: 305/809 - (37%)
• Gaps: 223/809 - (27%)

  Fly   596 STSCTNSFNRRHIRRHKGKLGDRLLSGDSEESVRCSYCSVLNVNDNDLRISFENTCTDSLV---- 656
            |::|:..:         |:|.|:    .:.|.||.::       ||     :|:.|.:.|:
Mouse    62 SSTCSFMY---------GELTDK----KTIEKVRQTF-------DN-----YESNCFEVLLYKKN 101

  Fly   657 --------------TAFDDEALLICDQGTEMVHFDDVSLYGTPKEEPMPNIPIVSEKVSANFL-- 705
                          ...:...|.:|.       |.|::|:..|.|:.       |.|....|.
Mouse   102 RTPVWFYMQIAPIRNEHEKVVLFLCT-------FKDITLFKQPIEDD-------STKGWTKFARL 152

  Fly   706 -------KSQLQSWFQPTD--------NRLAMKL-FGSRKALVKERIRQKTSGHWVIHPCSSFRF 754
                   :|.||. ..|.:        :|||..| .||......::...||..|.::|.| :|:.
Mouse   153 TRALTNSRSVLQQ-LTPMNKTETVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYC-AFKT 215

  Fly   755 YWDLCMLLLLVANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVI 819
            .||..:|:|.....|::|..:||.....:..|:..:.:.|.|||:|||:||.|..:....  :||
Mouse   216 TWDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGG--EVI 278

  Fly   820 LDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSL 884
            .|||||..:||:|||.:||:|.:|.|.|              ::|:.:..|    |..|...|.:
Mouse   279 SDPKLIRMNYLKTWFVIDLLSCLPYDII--------------NAFENVDEG----ISSLFSSLKV 325

  Fly   885 VRLLRLSRLVR----YVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFM 945
            ||||||.|:.|    |:.....|.:|
Mouse   326 VRLLRLGRVARKLDHYLEYGAAVLVL--------------------------------------- 351

  Fly   946 RIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSI----------NELQESYWLEQ------- 993
                |:|:..|:.||..|:              |.||          |.:|...||.|
Mouse   352 ----LVCVFGLVAHWLACI--------------WYSIGDYEVIDEVTNTIQIDSWLYQLALSIGT 398

  Fly   994 --------------------YSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYALF 1038
                                |..:|:..|:.:..||:|...|.:..:...::..|:.|:..||..
Mouse   399 PYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATI 463

  Fly  1039 LGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRY-QGKFFDEELILGEL 1102
            .|:.|.:.|.:.::..:|.|.:..|.:::...::|:.:.:|:.:|....: ..|..|.|.:|...
Mouse   464 FGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSIC 528

  Fly  1103 SEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEG 1167
            .:.:|.|:..:..|.:....|.|..|....:..:..:.:.....|||:|...|.....:.|:..|
Mouse   529 PKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSG 593

  Fly  1168 VVDIVMANGEVATSLSDGSYFGEICL--LTNARRVASVRAETYCNLFSLSVDHFNCVLDQYPLMR 1230
            .::::. :.||...|..|..||:|..  .|.|...|:|||.|||:|..:..:....|||.|....
Mouse   594 SLEVIQ-DEEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFA 657

  Fly  1231 KTM-----------ETVAAERLNKIGK-NPNIMHQKDE-QLSNPESNTITAVVNALAAEADDCKD 1282
            .:.           :.:...:::.:.| ....:.||:| .||.|..:.:..:......:
Mouse   658 NSFSRNLTLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQ------ 716

  Fly  1283 DDMDLKENLLHGSESSIAEPVQTIREGLP 1311
                 ||..:.||..|..|..|...|..|
Mouse   717 -----KELRIQGSAQSDPERSQLQVESRP 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:400630	14/50 (28%)
		PLN03192	741..>1214	CDD:215625	125/516 (24%)
Kcnh5	NP_766393.2	PAS_9	39..132	CDD:463873	17/101 (17%)
		PLN03192	217..>616	CDD:215625	110/476 (23%)
		Selectivity filter. /evidence=ECO:0000250	432..437		2/4 (50%)
		Crp	551..758	CDD:440428	46/202 (23%)
		Calmodulin-binding. /evidence=ECO:0000255	704..715		0/10 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	721..741		7/20 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	838..893
		CAD (involved in subunit assembly). /evidence=ECO:0000250	909..948