Protein Alignment Ih and KCNH4

DIOPT Version :10

• Sequence 1: NP_001033948.1
• Gene: Ih / 36589
• FlyBaseID: FBgn0263397
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: NP_036417.1
• Gene: KCNH4 / 23415
• HGNCID: 6253
• Length: 1017
• Species: Homo sapiens
• Alignment Length: 695
• Identity: 156/695 - (22%)
• Similarity: 265/695 - (38%)
• Gaps: 220/695 - (31%)

  Fly   688 EPMPNIPIVSEKVSANFLKSQLQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSSF 752
            ||.|::|  ..||::                     :.|||..|:          |:     |..
Human   199 EPKPSVP--EYKVAS---------------------VGGSRCLLL----------HY-----SVS 225

  Fly   753 RFYWDLCMLLLLVANLIILPVAISFFNDD----LSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQD 813
            :..||..:||......:.:|..:.|..||    .|...:..:...:.:|::||::||||..:.|.
Human   226 KAIWDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQS 290

  Fly   814 NAEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRL 878
            .  |||..|:.|..|||.||||:|||:::|.|.:: |||                    :.:..|
Human   291 G--QVISAPRSIGLHYLATWFFIDLIAALPFDLLY-IFN--------------------ITVTSL 332

  Fly   879 AKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASV 943
            ..||..||||||.||            ||.|::.|               ..|.::|..|
Human   333 VHLLKTVRLLRLLRL------------LQKLERYS---------------QCSAVVLTLL----- 365

  Fly   944 FMRIFNLICMMLLIGHWSGCLQFLV---------PMLQGFPSNSWVSINELQESYWLEQ------ 993
             |.:|      .|:.||..|:.:::         |:|       |       :..||.:
Human   366 -MSVF------ALLAHWMACIWYVIGRREMEANDPLL-------W-------DIGWLHELGKRLE 409

  Fly   994 ----------------YSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYALFLGHA 1042
                            |..||:..:|.:..:|:|.....:..:...::.:|:.||..:|:..|:.
Human   410 VPYVNGSVGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNV 474

  Fly  1043 TNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRYQ-GKFFDEELILGELSEKL 1106
            |.:||.:.|.|..|..::|.:::::...:|||.::||:.|||:..:. ....|...:|.:..::|
Human   475 TAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDEL 539

  Fly  1107 REDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDI 1171
            |.|:..:..|.:: .:|.|..|....:..:...:|.....||:.:::.|......|::..|.:::
Human   540 RADIAMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEV 603

  Fly  1172 VMANGEVATSLSDGSYFG----------------EICLLTNARRVASVRAETYCNLFSLSVDHFN 1220
            :..| .|...|..|...|                ...|.|:    |.|:|.|||.|..||.....
Human   604 LRDN-MVLAILGKGDLIGADIPEPGQEPGLGADPNFVLKTS----ADVKALTYCGLQQLSSRGLA 663

  Fly  1221 CVLDQYP----------------LMRKTMETVAAERLNKIGKNPNIMHQKDEQLSNPESNTITAV 1269
            .||..||                .:|:..:|   ..|::..::|.:...:.|.|.:....|:.::
Human   664 EVLRLYPEYGAAFRAGLPRDLTFNLRQGSDT---SGLSRFSRSPRLSQPRSESLGSSSDKTLPSI 725

  Fly  1270 VNALAAEADDCKDDDMDLKENLLHGSESSIAEPVQTIREGLPRPR 1314
            ..|                        .|.|||     .|.||||
Human   726 TEA------------------------ESGAEP-----GGGPRPR 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:400630	5/41 (12%)
		PLN03192	741..>1214	CDD:215625	123/524 (23%)
KCNH4	NP_036417.1	PRK13559	41..>179	CDD:237427
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	138..157
		PLN03192	177..>620	CDD:215625	123/536 (23%)
		Selectivity filter. /evidence=ECO:0000250	439..444		1/4 (25%)
		cNMP-binding domain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00060	556..620		12/64 (19%)
		cNMP_binding	578..667	CDD:459637	22/93 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	691..749		16/83 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	772..803
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	821..875
		PHA02682	838..>999	CDD:177464
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	971..1017