DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ih and Cnga4

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_001028489.1	Gene:	Cnga4 / 233649	MGIID:	2664099	Length:	575	Species:	Mus musculus

Alignment Length:	636	Identity:	156/636 - (24%)
Similarity:	267/636 - (41%)	Gaps:	143/636 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   744 W--VIHPCSSFRFYWDLCMLLLLVANLIILPVAISFFNDDLS----TRWIAFNCLSDTIFLIDIV 802
            |  |:.|...:.::|...|:..::.||||:.....|  .||.    ..|...:..||.::|:||.
Mouse    23 WLPVLDPSGDYYYWWLNTMVFPIMYNLIIVVCRACF--PDLQHSYLVAWFVLDYTSDLLYLLDIG 85

  Fly   803 VNFRTGIMQQDNAEQVILDPKLIAKHYLRTW-FFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQI 866
            |.|.||.::|.   .:::|..:||..|:||| |.|||.|.:|.|..:
Mouse    86 VRFHTGFLEQG---ILVVDKSMIASRYVRTWSFLLDLASLVPTDAAY------------------ 129

  Fly   867 LHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKS 931
            :..|..:..|||.      |.||:.||.....:.|......|.
Mouse   130 VQLGPHIPTLRLN------RFLRVPRLFEAFDRTETRTAYPNA---------------------- 166

  Fly   932 NLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSINELQESY--WLEQY 994
                         .||..|:..:.::.||:.||.|.:....||..::||..:..|..:  ...||
Mouse   167 -------------FRIAKLMIYIFVVIHWNSCLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQY 218

  Fly   995 SWALFKAMSHMLCIGYGRFPPQSLTDMWLTML-SMISGATCYALFLGHATNLIQSLDSSRRQYRE 1058
            .::.:  .|.::....|..|..:..:.:|.|: ..:.....:|..:|..:::|.:::::...:..
Mouse   219 LYSFY--FSTLILTTVGDTPLPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYP 281

  Fly  1059 KVKQVEEYMAYRKLPRDMRQRITEYFEH-RYQGKFFDEELILGELSEKLREDVINYNCRSLVASV 1122
            ....|::||..:.:.|.:.:|:.::::| :...|..:|..||..|.|:||.:|......|.::.|
Mouse   282 DHALVKKYMKLQHVNRRLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRV 346

  Fly  1123 PFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATS-LSDGS 1186
            ..|.|.:::.:.::|.||:.:.:.||:.:.::|.||.:||.|:||.:.:|..:|....: |..|.
Mouse   347 QIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGREMYIIREGQLAVVADDGVTQYAVLGAGL 411

  Fly  1187 YFGEICL------LTNARRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAERLNKIG 1245
            |||||.:      ::..||.|::::..|.:||.||.:....||.:||..:..||....|.|.|:.
Mouse   412 YFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQAVMEEKGREILLKMN 476

  Fly  1246 KNPNIMHQKDEQLSNPESNTITAVVNALAAEAD------------DCKDDDMDLK-ENLLHGSES 1297
            |                     ..|||.|||..            |.:.||:..| ..||...||
Mouse   477 K---------------------LDVNAEAAEIALQEATESRLKGLDQQLDDLQTKFARLLAELES 520

  Fly  1298 S---IAEPVQTI----REGLPRP-----------------RSGEFRALFEG 1324
            |   ||..::.:    || .|.|                 :.||.:|..||
Mouse   521 SALKIAYRIERLEWQTRE-WPMPDDMGEADDEAEPGEGTSKDGEEKAGQEG 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	3/8 (38%)
		Ion_trans	771..1054	CDD:278921	62/290 (21%)
		Crp	1118..>1241	CDD:223736	40/129 (31%)
		CAP_ED	1124..1233	CDD:237999	36/115 (31%)
Cnga4	NP_001028489.1	Ion_trans	34..273	CDD:366146	68/304 (22%)
		IQ-type. /evidence=ECO:0000250	292..302		1/9 (11%)
		CAP_ED	348..464	CDD:237999	36/115 (31%)
		CLZ	464..534	CDD:374604	23/90 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..575		9/36 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920