Protein Alignment Ih and Kcnh8

DIOPT Version :9

• Sequence 1: NP_001033948.1
• Gene: Ih / 36589
• FlyBaseID: FBgn0263397
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: XP_036016335.1
• Gene: Kcnh8 / 211468
• MGIID: 2445160
• Length: 1103
• Species: Mus musculus
• Alignment Length: 644
• Identity: 145/644 - (22%)
• Similarity: 271/644 - (42%)
• Gaps: 140/644 - (21%)

  Fly   718 NRLAM--KLFGSRKALVKERIRQKTSGHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISFF-N 779
            |:|.:  .:|..:.|..:.::.......:::...|:|:..||..:||......:.:|..:.|. |
Mouse   184 NKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGN 248

  Fly   780 DDLSTRWIAFNCLSD----TIFLI-DIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLI 839
            :||||  .....:||    .:|:| ||::||||..:.:..  |||.:.:.|..||:.|||.:|||
Mouse   249 EDLST--TRSTTVSDIAVEILFIIADIILNFRTTYVSKSG--QVIFEARSICIHYVTTWFIIDLI 309

  Fly   840 SSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVY 904
            :::|.|.:: .||                    :.::.|..||..||||||.||
Mouse   310 AALPFDLLY-AFN--------------------VTVVSLVHLLKTVRLLRLLRL----------- 342

  Fly   905 ILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVP 969
             ||.|.:.|               ..|.::|..            |:.|..|:.||..|:.:::.
Mouse   343 -LQKLDRYS---------------QHSTIVLTL------------LMSMFALLAHWMACIWYVIG 379

  Fly   970 MLQGFPSNS---WVSINELQESYWLEQ-----------------------YSWALFKAMSHMLCI 1008
            .::. ..||   |       |..||.:                       |..||:..:|.:..:
Mouse   380 KMER-EDNSLLKW-------EVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSV 436

  Fly  1009 GYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLP 1073
            |:|.....:..:...::.:|:.||..:||..|:.|.:||.:.|....|..:.|.:::::....||
Mouse   437 GFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLP 501

  Fly  1074 RDMRQRITEYFEHRYQ-GKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVV 1137
            :.::||:.|||:..:. ....|...:|.:..::||.| |..:....:..:..|..|....:..:.
Mouse   502 QQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSD-ITMHLNKEILQLSLFECASRGCLRSLS 565

  Fly  1138 TKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYFG------EICLLTN 1196
            ..:|.....||:.::::|.....:||:..|.:: |:.:..|...|..|...|      :..:.||
Mouse   566 LHIKTSFCAPGEYLLRQGDALQAIYFVCSGSME-VLKDSMVLAILGKGDLIGANLSIKDQVIKTN 629

  Fly  1197 ARRVASVRAETYCNLFSLSVDHFNCVLDQYP-LMRKTMETVAAERLNKIGKNPNIMHQKD--EQL 1258
                |.|:|.|||:|..:.:.....||..|| ...|.:|.:..:....:.:.    |:.|  .:|
Mouse   630 ----ADVKALTYCDLQCIILKGLFEVLGLYPEYAHKFVEDIQHDLTYNLREG----HESDVISRL 686

  Fly  1259 SN--------PESNTITAVVNALAAEADDCKDDDMDLKENL----LHGSESSIAEPVQT 1305
            ||        |:.|  .::...|.:..:|.::::::.:|..    ::...||::...:|
Mouse   687 SNKSTVSQAEPKGN--GSINKRLPSIVEDEEEEEVEEEETTSLSPIYTRGSSVSHSKKT 743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	4/34 (12%)
		Ion_trans	771..1054	CDD:278921	78/314 (25%)
		Crp	1118..>1241	CDD:223736	29/129 (22%)
		CAP_ED	1124..1233	CDD:237999	28/115 (24%)
Kcnh8	XP_036016335.1	PAS_9	40..135	CDD:404329
		PLN03192	175..>616	CDD:215625	116/505 (23%)
		Crp	549..708	CDD:223736	36/169 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810