DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ih and Kcnh6

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_001032801.1	Gene:	Kcnh6 / 192775	MGIID:	2684139	Length:	950	Species:	Mus musculus

Alignment Length:	669	Identity:	156/669 - (23%)
Similarity:	258/669 - (38%)	Gaps:	183/669 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   735 RIRQKTSGHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISFF---NDDLSTRWIAFNC----- 791
            ||.:.|..|:     |.|:..||..:|||::...:..|.:.:|.   .||.......:.|
Mouse   243 RIHRGTILHY-----SPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDDSQRGTCGYTCSPLTV 302

  Fly   792 ---LSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQ 853
               :.|.:|::|||:||||..:..:  ::|:..|:.||.||.:.||.:|::::||.|  .|||
Mouse   303 VDLIVDIMFVVDIVINFRTTYVNTN--DEVVSHPRRIAVHYFKGWFLIDMVAAIPFD--LLIF-- 361

  Fly   854 IMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRG 918
                :..||....|     :.:|:.|:||.|||:.|  :|.||......|
Mouse   362 ----RTGSDETTTL-----IGLLKTARLLRLVRVAR--KLDRYSEYGAAV--------------- 400

  Fly   919 RMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSIN 983
                                        :|.|:|...||.||..|:              |.:|.
Mouse   401 ----------------------------LFLLMCTFALIAHWLACI--------------WYAIG 423

  Fly   984 ELQESY------WL-----------------------EQYSWALFKAMSHMLCIGYGRFPPQSLT 1019
            .::..|      ||                       ::|..||:...|.:..:|:|...|.:.:
Mouse   424 NVERPYLEPKIGWLDSLGAQLGKHYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNS 488

  Fly  1020 DMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYF 1084
            :...::..|:.|:..||...|:.:.:||.|.|...:|..::.:|:|::.:.::|..:|||:.|||
Mouse   489 EKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYF 553

  Fly  1085 EHRYQ-GKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPG 1148
            :|.:. ....|...:|....|.|:.|:..:..|:|:...|.|..|....:..:..|.|.....||
Mouse   554 QHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFRGASKGCLRALAVKFKTTHAPPG 618

  Fly  1149 DIIIKEGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYFGEICLLTNAR---RVASVRAETYCN 1210
            |.::..|.:.:.:|||..|.::| :.:..|...|.....|||...| :||   ..|.|||.|||:
Mouse   619 DTLVHLGDVLSTLYFISRGSIEI-LRDDVVVAILGKNDIFGEPASL-HARPGKSSADVRALTYCD 681

  Fly  1211 LFSLSVDHFNCVLDQYPLMRKTM--------------------------------------ETVA 1237
            |..:.......|||.||....|.                                      ::.|
Mouse   682 LHKIHRADLLEVLDMYPAFADTFWNKLEVTFNLRDADGGLHSTPRQAPGNQDPQGFFLNDSQSGA 746

  Fly  1238 AERL---NKIGKNPNIMHQKDEQLSNPESNTITAVVNALAAEADDCKDDDMDLKENLLHGS---- 1295
            |..|   :..|..|.::.|......||.             |..||...::..|...|...
Mouse   747 APSLSISDTSGLWPELLQQMPPSPPNPR-------------EKLDCWPRELGFKLEQLQAQMNRL 798

  Fly  1296 ESSIAEPVQTIREGLPRPR 1314
            ||.::..:..|.:.|..|:
Mouse   799 ESRVSSDLSRILQLLQHPQ 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	4/15 (27%)
		Ion_trans	771..1054	CDD:278921	73/322 (23%)
		Crp	1118..>1241	CDD:223736	39/163 (24%)
		CAP_ED	1124..1233	CDD:237999	34/111 (31%)
Kcnh6	NP_001032801.1	PAS_9	29..132	CDD:290162
		PAS	41..132	CDD:238075
		Ion_trans	296..520	CDD:278921	68/297 (23%)
		Ion_trans_2	<463..517	CDD:285168	13/53 (25%)
		Crp	588..>701	CDD:223736	36/114 (32%)
		CAP_ED	594..705	CDD:237999	35/112 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810