Protein Alignment Ih and Kcnh5

DIOPT Version :10

• Sequence 1: NP_001033948.1
• Gene: Ih / 36589
• FlyBaseID: FBgn0263397
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: NP_598294.1
• Gene: Kcnh5 / 171146
• RGDID: 621417
• Length: 988
• Species: Rattus norvegicus
• Alignment Length: 761
• Identity: 171/761 - (22%)
• Similarity: 294/761 - (38%)
• Gaps: 204/761 - (26%)

  Fly   596 STSCTNSFNRRHIRRHKGKLGDRLLSGDSEESVRCSYCSVLNVNDNDLRISFENTCTDSLV---- 656
            |::|:..:         |:|.|:    .:.|.||.::       ||     :|:.|.:.|:
  Rat    62 SSTCSFMY---------GELTDK----KTIEKVRQTF-------DN-----YESNCFEVLLYKKN 101

  Fly   657 --------------TAFDDEALLICDQGTEMVHFDDVSLYGTPKEEPMPNIPIVSEKVSANFL-- 705
                          ...:...|.:|.       |.|::|:..|.|:.       |.|....|.
  Rat   102 RTPVWFYMQIAPIRNEHEKVVLFLCT-------FKDITLFKQPIEDD-------STKGWTKFARL 152

  Fly   706 -------KSQLQSWFQPTD--------NRLAMKL-FGSRKALVKERIRQKTSGHWVIHPCSSFRF 754
                   :|.||. ..|.:        :|||..| .||......::...||..|.::|.| :|:.
  Rat   153 TRALTNSRSVLQQ-LTPMNKTETVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYC-AFKT 215

  Fly   755 YWDLCMLLLLVANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVI 819
            .||..:|:|.....|::|..:||.....:..|:..:.:.|.|||:|||:||.|..:....  :||
  Rat   216 TWDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGG--EVI 278

  Fly   820 LDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSL 884
            .|||||..:||:|||.:||:|.:|.|.|              ::|:.:..|    |..|...|.:
  Rat   279 SDPKLIRMNYLKTWFVIDLLSCLPYDII--------------NAFENVDEG----ISSLFSSLKV 325

  Fly   885 VRLLRLSRLVR----YVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFM 945
            ||||||.|:.|    |:.....|.:|
  Rat   326 VRLLRLGRVARKLDHYLEYGAAVLVL--------------------------------------- 351

  Fly   946 RIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSI----------NELQESYWLEQ------- 993
                |:|:..|:.||..|:              |.||          |.:|...||.|
  Rat   352 ----LVCVFGLVAHWLACI--------------WYSIGDYEVIDEVTNTIQIDSWLYQLALSIGT 398

  Fly   994 --------------------YSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYALF 1038
                                |..:|:..|:.:..||:|...|.:..:...::..|:.|:..||..
  Rat   399 PYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATI 463

  Fly  1039 LGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRY-QGKFFDEELILGEL 1102
            .|:.|.:.|.:.::..:|.|.:..|.:::...::|:.:.:|:.:|....: ..|..|.|.:|...
  Rat   464 FGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSIC 528

  Fly  1103 SEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEG 1167
            .:.:|.|:..:..|.:....|.|..|....:..:..:.:.....|||:|...|.....:.|:..|
  Rat   529 PKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSG 593

  Fly  1168 VVDIVMANGEVATSLSDGSYFGEICL--LTNARRVASVRAETYCNLFSLSVDHFNCVLDQYPLMR 1230
            .::::. :.||...|..|..||:|..  .|.|...|:|||.|||:|..:..:....|||.|....
  Rat   594 SLEVIQ-DEEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFA 657

  Fly  1231 KTME---TVAAERLNKI--GKNPNIMHQKDEQLSNPESNTITAVVN 1271
            .:..   |:......:|  .|..::..:::|:|......|::..|:
  Rat   658 NSFSRNLTLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTLSIPVD 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:400630	14/50 (28%)
		PLN03192	741..>1214	CDD:215625	125/516 (24%)
Kcnh5	NP_598294.1	PAS_9	39..132	CDD:463873	17/101 (17%)
		PLN03192	217..>616	CDD:215625	110/476 (23%)
		Selectivity filter. /evidence=ECO:0000250	432..437		2/4 (50%)
		Crp	551..758	CDD:440428	37/154 (24%)
		Calmodulin-binding. /evidence=ECO:0000255	704..715		171/761 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	718..742
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	839..897
		CAD (involved in subunit assembly). /evidence=ECO:0000250	909..948
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	946..965