DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ih and Kcnh3

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	XP_006520546.1	Gene:	Kcnh3 / 16512	MGIID:	1341723	Length:	1101	Species:	Mus musculus

Alignment Length:	708	Identity:	160/708 - (22%)
Similarity:	270/708 - (38%)	Gaps:	189/708 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   705 LKSQLQSWFQPT-DNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSSFRFYWDLCMLL--LLVA 766
            |...||.  ||. .::|...:||.:..|.:.::.......:::..|.:.|..||..:||  |.||
Mouse   183 LSGHLQK--QPKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVA 245

  Fly   767 NLIILPVAISFFNDDLSTRWIAFNC--LSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHY 829
            ..:...|.:|...:..:.|.....|  ..:.:|::|||:||||..:.:..  ||:..||.|..||
Mouse   246 VTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSG--QVVFAPKSICLHY 308

  Fly   830 LRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLV 894
            :.|||.||:|:::|                    |.:|||.: :.:...|.||..||||||.||:
Mouse   309 VTTWFLLDVIAALP--------------------FDLLHAFK-VNVYVGAHLLKTVRLLRLLRLL 352

  Fly   895 ----RYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMML 955
                || ||:..|.:                                    ::.|.:|      .
Mouse   353 PRLDRY-SQYSAVVL------------------------------------TLLMAVF------A 374

  Fly   956 LIGHWSGCLQFLVPMLQGFPSNSWVSINELQESYWLEQ--------------------------- 993
            |:.||..|:.|.:...:...|.|     ||.|..||::
Mouse   375 LLAHWVACVWFYIGQQEIESSES-----ELPEIGWLQELARRLETPYYLVSRSPDGGNSSGQSEN 434

  Fly   994 ----------------------------------YSWALFKAMSHMLCIGYGRFPPQSLTDMWLT 1024
                                              |..:|:.|:|.:..:|:|.....:.|:...:
Mouse   435 CSSSSSSSGSGGGRGSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFS 499

  Fly  1025 MLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRYQ 1089
            :.:|:.||..:|:..|:.|.:||.:.:.|..|..:.:.:.:|:...::|:.::||:.|||:..:.
Mouse   500 ICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWA 564

  Fly  1090 -GKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIK 1153
             ....|...:|..|.::||.| |..:....|..:|.|..|....:..:...|:.....||:.:|.
Mouse   565 VNNGIDTTELLQSLPDELRAD-IAMHLHKEVLQLPLFEAASRGCLRALSLALRPAFCTPGEYLIH 628

  Fly  1154 EGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYFGEICLLTNARRV----ASVRAETYCNLFSL 1214
            :|.....:||:..|.:: |:..|.|...|..|...|  |.|....:|    |.|:..|||.|..|
Mouse   629 QGDALQALYFVCSGSME-VLKGGTVLAILGKGDLIG--CELPQREQVVKANADVKGLTYCVLQCL 690

  Fly  1215 SVDHFNCVLDQYPLMRKTMETVAAERLNKIGKNPNIMHQKDEQLSNPESNTITAVVNALAAEADD 1279
            .:...:..|..||..        |.|.::        ..:.|...|..:..::|.|:..:...|:
Mouse   691 QLAGLHESLALYPEF--------APRFSR--------GLRGELSYNLGAGGVSAEVDTSSLSGDN 739

  Fly  1280 CKDDDMDLKEN--------------------LLHG-SESSIAEPVQTIREGLPRPRSG 1316
            .....::.||.                    |..| :.||.|..:.:.|...||||.|
Mouse   740 TLMSTLEEKETDGEQGHTVSPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLG 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	9/42 (21%)
		Ion_trans	771..1054	CDD:278921	75/349 (21%)
		Crp	1118..>1241	CDD:223736	32/126 (25%)
		CAP_ED	1124..1233	CDD:237999	29/112 (26%)
Kcnh3	XP_006520546.1	PAS_9	40..135	CDD:379177
		PLN03192	233..>668	CDD:215625	118/509 (23%)
		cyc_nuc_ocin	<623..718	CDD:274839	28/113 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835138
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740