Protein Alignment Ih and CngA

DIOPT Version :10

• Sequence 1: NP_001033948.1
• Gene: Ih / 36589
• FlyBaseID: FBgn0263397
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: XP_061510131.1
• Gene: CngA / 1280008
• VectorBaseID: AGAMI1_009565
• Length: 853
• Species: Anopheles gambiae
• Alignment Length: 1028
• Identity: 202/1028 - (19%)
• Similarity: 358/1028 - (34%)
• Gaps: 334/1028 - (32%)

  Fly   328 NTTH--PQASSAPASSSSTCTKAPQLPALSAVAARQQQLLLNGSLKGKGQSQSQGQSRQTLPGHR 390
            ||||  ||.|:.|.|.|:|       |.              ||     .:..|....||
Mosquito    46 NTTHRAPQLSNGPVSISTT-------PF--------------GS-----NTIYQSYMPQT----- 79

  Fly   391 ASVRSESGSGSSHTIPATGKSPPVPHSLAAKISSSASGSKNCNLLSASSNSCHKLNAHAQGSGAG 455
            ||:.|.:...::.:...||.:||.|...:.:::.:
Mosquito    80 ASLDSFNSVATNPSFSTTGGTPPPPLGGSGRVAPA------------------------------ 114

  Fly   456 SGSGSGSGSGP-PGHSHYAAASPKSSVSSNGHLNKYCLTDLTRRKAEFNRQLSAPTDYTHHS--- 516
                :|||:.| .|....|||:               |...||.:.|...:|.......|.|
Mosquito   115 ----TGSGTTPTAGRRQQAAAA---------------LPFTTRNRPEVATELPVTPKNNHLSQAV 160

  Fly   517 --SSNGSQQEGSSEANEG-----HEPVGESTITVASAGVSYPHPYSYPYHYAHHASSATAPANLK 574
              |..|..|:..|....|     ...:......::..|.|.|     |..:....|:|:|.::.:
Mosquito   161 IESERGDVQDQPSAGRRGKLSSLRRSLNALRCRISKRGRSKP-----PDQFLDKFSAASATSDTR 220

  Fly   575 ASLQLHSFGSHHPCPYPARPTSTSCTNSFNRRHIRRHKGKLGDRLLSGDSEESVRCSYCSVLNVN 639
                ||..|...|...|:.                                     ..||.|:|:
Mosquito   221 ----LHQAGCVAPQAVPSD-------------------------------------GVCSRLSVD 244

  Fly   640 DNDLRISFENTCTDSLVTAFDDEALLICDQGTEMVHFDDVSLYGTPKEEPMPNIPIVSEKVSANF 704
                                                               |::|
Mosquito   245 ---------------------------------------------------PSLP---------- 248

  Fly   705 LKSQLQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSSFRFYWDLCMLLLLVANLI 769
                                                         |.:|  | |.::.|.|...|
Mosquito   249 ---------------------------------------------SHYR--W-LSVVSLAVLYNI 265

  Fly   770 ILPVAISFF---NDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYL- 830
            |..:..:.|   |...|..|...:.|.|.|:|.|.:|:...|.::|.   .::.|...:.|||.
Mosquito   266 IFVIGRAVFWELNKQASVLWWILDYLCDFIYLTDTLVHCHEGYLEQG---LLVRDAPKLRKHYFS 327

  Fly   831 --RTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRL 893
              |.|  ||::|.:|.|..:                 |..|..:....||...:    ::|::||
Mosquito   328 KQRWW--LDVVSMLPTDLAY-----------------IWWAPSSCAATRLPCPI----IVRINRL 369

  Fly   894 VRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIG 958
            :|....||..       .::....|..|.                      .||..::..:|::.
Mosquito   370 LRLPRMWEWF-------DRTETATGYPNA----------------------FRICKVVLAILVLI 405

  Fly   959 HWSGCLQFLVPMLQGFPSNSWV-SINELQESYWLEQYSWALFKAMSHMLCIGYGRFP-PQSLTDM 1021
            ||:.||.|.:....||.:::|| :||..:......||.::.:  .|.:.....|..| |::..:.
Mosquito   406 HWNACLYFAISYALGFSTDNWVYNINGPKNLTLSRQYIYSFY--WSTLTLTTIGETPTPENDAEY 468

  Fly  1022 WLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEH 1086
            ...:...::|...:|..:|:..::|.:::.:|.:::.::..|::|||:||:..::..|:..:|.:
Mosquito   469 LFVVADFLAGVLIFATIVGNIGSMISNMNVTRVEFQNRMDGVKQYMAFRKVGGELEARVIRWFAY 533

  Fly  1087 RY-QGKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDI 1150
            .: |....|||.:|..|.:||:.::........:..|..|.:.:...:..:|.|||.:||.|||.
Mosquito   534 TWAQSGALDEERVLAALPDKLKAEIAIRVHMDTLRQVRIFQDCEPGLLEALVLKLKLQVFSPGDY 598

  Fly  1151 IIKEGTIGTKMYFIQEGVVDIVMANG-EVATSLSDGSYFGEICLL------TNARRVASVRAETY 1208
            |.::|.:|.:||.::.|.:.:|..:| .|..:|..||.|||:.:|      |..||.|:||:..|
Mosquito   599 ICRKGDVGKEMYIVKRGSLSVVADDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSIGY 663

  Fly  1209 CNLFSLSVDHFNCVLDQYPLMRKTMETVAAERLNKIGKNPNIMHQKDEQLSNPESNTITAVVNAL 1273
            .:||.|:.......|..||..|.::.....:.|.|.|       ..||.:......|..::.:.:
Mosquito   664 SDLFCLAKRDLWETLADYPEARASLTERGCQLLRKDG-------LLDEAVFANAQQTQDSLESGV 721

  Fly  1274 AAEADDCKDDDMDLKENLLH--GSESSIAEPVQTIREGLPRP----RSGEFRA 1320
            |......::.::.|...|..  .|::.:.:.:..:.:.:.:|    |..|.:|
Mosquito   722 ARLEQTVENLNLRLARLLAEYSASQAKLKQRISKLEDRVQKPSPTSRGAEAKA 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:400630	0/41 (0%)
		PLN03192	741..>1214	CDD:215625	120/488 (25%)
CngA	XP_061510131.1	None