DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ih and CNGB1

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_001288.3	Gene:	CNGB1 / 1258	HGNCID:	2151	Length:	1251	Species:	Homo sapiens

Alignment Length:	1042	Identity:	228/1042 - (21%)
Similarity:	396/1042 - (38%)	Gaps:	231/1042 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 LQPQVASTSSSINTTHPQASSAPASSSSTCTKAP-QLPA--LSAVAARQQQLLLNGSLKGKGQSQ 377
            |||:  ..........||..|...:||...|:.| :|.|  |..:.....|.:|:|.: |:.:..
Human   221 LQPK--EEPKEAPAPEPQPGSQAQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKI-GEQEPD 282

  Fly   378 SQG----QSRQTLPG-------------------HRASVRSESGSGSSHTIPATGKSPPVPHSLA 419
            |.|    |:...|||                   |:....|..|   :..:||..:.......:.
Human   283 SPGICDVQTISILPGGQVEPDLVLEEVEPPWEDAHQDVSTSPQG---TEVVPAYEEENKAVEKMP 344

  Fly   420 AKIS-------------SSASGSKNCNLLSASSNSCHKLNAHAQGSGAGSGSGSGSGSGPPGHSH 471
            .::|             ......:...:.....:||       ..|..|.|.....|:.|
Human   345 RELSRIEEEKEDEEEEEEEEEEEEEEEVTEVLLDSC-------VVSQVGVGQSEEDGTRP----- 397

  Fly   472 YAAASPKSSVSSNGHLNKYCLTDLTRRKAEFNRQLSAPTDYTHHSSSNGSQQEGSSEANEGHEPV 536
             .:.|.:......|...|....:..:.:||             ..:...:::|....|....||
Human   398 -QSTSDQKLWEEVGEEAKKEAEEKAKEEAE-------------EVAEEEAEKEPQDWAETKEEP- 447

  Fly   537 GESTITVASAGVSYPHPYSYPYHYAHHASSATAPANLKASLQLHSFGSHHPCPYPAR------PT 595
             |:....||:||  |....:|........:.:.|  |.|.....|  :..|.|.||:      |:
Human   448 -EAEAEAASSGV--PATKQHPEVQVEDTDADSCP--LMAEENPPS--TVLPPPSPAKSDTLIVPS 505

  Fly   596 STSCTNSFNRRHIRRHKGKL------GDRLLSGDSEESVRCSYCSVLNVNDNDLRISFENTCTDS 654
            |.|.|          |:.||      .:.|.:....||...::.......|.|.:....:|.:.:
Human   506 SASGT----------HRKKLPSEDDEAEELKALSPAESPVVAWSDPTTPKDTDGQDRAASTASTN 560

  Fly   655 LVTAFD--DEALLICDQGTE-----MVHFDDVSLYGTPK-------EEPMPNI-PIVSEKVSANF 704
            .....|  .|.:.:..:.||     ::..|..|...:||       .||.|:. |..:|.|....
Human   561 SAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKPSPAKKAPEPAPDTKPAEAEPVEEEH 625

  Fly   705 LKSQLQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSSFRF-YWDLCMLLLLVANL 768
            ....|...|                   |.|..:|......|.|.::..: .|...:::....|.
Human   626 YCDMLCCKF-------------------KHRPWKKYQFPQSIDPLTNLMYVLWLFFVVMAWNWNC 671

  Fly   769 IILPV--AISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLR 831
            .::||  |..:...|....|:..:.|.|.|:.:||.| |:|. :|......:|.|.|.:..:||:
Human   672 WLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITV-FQTR-LQFVRGGDIITDKKDMRNNYLK 734

  Fly   832 T-WFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVR 895
            : .|.:||:|.:|||:::|                               .:.:..||||.|.::
Human   735 SRRFKMDLLSLLPLDFLYL-------------------------------KVGVNPLLRLPRCLK 768

  Fly   896 YVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHW 960
            |::.:|....|:::                            |:.|.|: |:......:|...|.
Human   769 YMAFFEFNSRLESI----------------------------LSKAYVY-RVIRTTAYLLYSLHL 804

  Fly   961 SGCLQFLVPMLQGFPSNSWVSINELQESYWLEQYSWALFKAMSHMLCIGYGRFPPQSLTDMWLTM 1025
            :.||.:.....||..|..|| .:.:..|| :..|    :.|:..::.|| |...|::|.::...:
Human   805 NSCLYYWASAYQGLGSTHWV-YDGVGNSY-IRCY----YFAVKTLITIG-GLPDPKTLFEIVFQL 862

  Fly  1026 LSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRYQG 1090
            |:..:|...:::.:|...:::.:..:.:..||..:....:||.:.|:|:.::.|:..::|:.:..
Human   863 LNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHS 927

  Fly  1091 K-FFDEELILGELSEKLREDV---INYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDII 1151
            : ..||..::.:|.:|:|.|:   :|||   :|:.|..|...|...:.|::.:|:..|:.|.|.:
Human   928 QGMLDESELMVQLPDKMRLDLAIDVNYN---IVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYV 989

  Fly  1152 IKEGTIGTKMYFIQEGVVDIVMA-NGE-VATSLSDGSYFGEICLLT---NARRVASVRAETYCNL 1211
            .|:|.||.:||.||.|.|.::.. :|: |..:|..||.||||.||.   ..||.|:|.|..:.||
Human   990 CKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNL 1054

  Fly  1212 FSLSVDHFNCVLDQYP----LMRKTMETVAAERLNKIGKNPNIMHQKDEQLSNPESNTITAVVNA 1272
            |.|.....|.:|..||    |:||     .|.|:.:....|.  .:|...:..|.:.|......|
Human  1055 FILDKKDLNEILVHYPESQKLLRK-----KARRMLRSNNKPK--EEKSVLILPPRAGTPKLFNAA 1112

  Fly  1273 LA 1274
            ||
Human  1113 LA 1114

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	7/41 (17%)
		Ion_trans	771..1054	CDD:278921	60/285 (21%)
		Crp	1118..>1241	CDD:223736	47/131 (36%)
		CAP_ED	1124..1233	CDD:237999	44/117 (38%)
CNGB1	NP_001288.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..75
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..151
		Trypan_PARP	<171..257	CDD:114603	11/37 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	172..252		9/32 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	314..561		50/293 (17%)
		IQ-like	568..578		1/9 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..619		8/33 (24%)
		Ion_trans	674..881	CDD:278921	60/275 (22%)
		Crp	956..>1093	CDD:223736	49/143 (34%)
		CAP_ED	962..1071	CDD:237999	40/108 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1151..1251
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920