Protein Alignment Ih and Kcnh2

DIOPT Version :9

• Sequence 1: NP_001033948.1
• Gene: Ih / 36589
• FlyBaseID: FBgn0263397
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: XP_006235929.2
• Gene: Kcnh2 / 117018
• RGDID: 621414
• Length: 1234
• Species: Rattus norvegicus
• Alignment Length: 1003
• Identity: 219/1003 - (21%)
• Similarity: 344/1003 - (34%)
• Gaps: 361/1003 - (35%)

  Fly   305 LNLYLVEKKHSLQPQVASTSSSINTTHPQASSAPASSSSTCTKAPQLPALSAVAARQQQLLLNGS 369
            ||..:|.:|..:      .|.:.:|.|...|::..:|....|...:||||.|:.||:..:
  Rat   198 LNFEVVMEKDMV------GSPAHDTNHRGPSTSWLASGRAKTFRLKLPALLALTARESPM----- 251

  Fly   370 LKGKGQSQSQGQSRQTLPGHRASVRSESGSGSSHTIPATGKSPPVPHSLAAKI--SSSASGSKNC 432
                                      .:||        || ||..|.::...:  :.:|..|::.
  Rat   252 --------------------------RTGS--------TG-SPGAPGAVVVDVDLTPAAPSSESL 281

  Fly   433 NL--LSASSNSCHKLNAHAQGSG--------AGSGSGS------GSGSGPPGHSHYAAASPKSSV 481
            .|  :||..|       |..|.|        .|..|.|      |....||..|    .:|.:|.
  Rat   282 ALDEVSAMDN-------HVAGLGPAEERRALVGPASASPVASIRGPHPSPPAQS----LNPDASG 335

  Fly   482 SSNGHLNKYCLTDLTRRKAEFNRQLSAPTDYTHHSSSNGSQQEGSSEANEGHEPVGESTITVASA 546
            ||       |....||.:                 .|..|.:..||          ...|....|
  Rat   336 SS-------CSLARTRSR-----------------ESCASVRRASS----------ADDIEAMRA 366

  Fly   547 GVSYPHPYSYPYHYAHHASSATAPANLKASLQLHSFGSHHPCPYPARPTSTSCTNSFNRRHIRRH 611
            |...|.|        .|||:                |:.||
  Rat   367 GALPPPP--------RHAST----------------GAMHP------------------------ 383

  Fly   612 KGKLGDRLLSGDSEESVRCSYCSVLNVNDNDLRISFENTCTDSLVTAFDDEALLICDQGTEMVHF 676
                                           ||....|:.:||
  Rat   384 -------------------------------LRSGLLNSTSDS---------------------- 395

  Fly   677 DDVSLYGTPKEEPMPNIPIVSEKVSANFLKSQLQSWFQPTDNR--LAMKLFGSRKALVKERIRQK 739
             |:..|.|..:.|...:..|..| ...||.|       ||.:|  :|.|: ..|...|.|::.|.
  Rat   396 -DLVRYRTISKIPQITLNFVDLK-GDPFLAS-------PTSDREIIAPKI-KERTHNVTEKVTQV 450

  Fly   740 TS----------------GHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISFFNDDLSTRWIA 788
            .|                ..|.|...|.|:..||..:|||::...:..|.:.:|...:......|
  Rat   451 LSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEDGSQA 515

  Fly   789 FNC------------LSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISS 841
            .:|            |.|.:|::||::||||..:..:  |:|:..|..||.||.:.||.:|::::
  Rat   516 PDCGYACQPLAVVDLLVDIMFIVDILINFRTTYVNAN--EEVVSHPGRIAVHYFKGWFLIDMVAA 578

  Fly   842 IPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYIL 906
            ||.|  .|||.        |.|.:::            .||...|||||.|:.|.:.::.|.
  Rat   579 IPFD--LLIFG--------SGSEELI------------GLLKTARLLRLVRVARKLDRYSEY--- 618

  Fly   907 QNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPML 971
                                             .|:|   :|.|:|...||.||..|:
  Rat   619 ---------------------------------GAAV---LFLLMCTFALIAHWLACI------- 640

  Fly   972 QGFPSNSWVSINELQESY------WL----------------------EQYSWALFKAMSHMLCI 1008
                   |.:|..:::.:      ||                      ::|..||:...|.:..:
  Rat   641 -------WYAIGNMEQPHMDSHIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSV 698

  Fly  1009 GYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLP 1073
            |:|...|.:.::...::..|:.|:..||...|:.:.:||.|.|...:|..::.:|.|::.:.::|
  Rat   699 GFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIP 763

  Fly  1074 RDMRQRITEYFEHRYQ-GKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVV 1137
            ..:|||:.|||:|.:. ....|...:|....|.|:.|:..:..|||:.....|..|....:..:.
  Rat   764 NPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALA 828

  Fly  1138 TKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATS-LSDGSYFGEICLL--TNARR 1199
            .|.|.....|||.::..|.:.|.:|||..|.::|:  .|:|..: |.....|||...|  ...:.
  Rat   829 MKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEIL--RGDVVVAILGKNDIFGEPLNLYARPGKS 891

  Fly  1200 VASVRAETYCNLFSLSVDHFNCVLDQYP 1227
            ...|||.|||:|..:..|....|||.||
  Rat   892 NGDVRALTYCDLHKIHRDDLLEVLDMYP 919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	12/59 (20%)
		Ion_trans	771..1054	CDD:278921	71/322 (22%)
		Crp	1118..>1241	CDD:223736	35/113 (31%)
		CAP_ED	1124..1233	CDD:237999	34/107 (32%)
Kcnh2	XP_006235929.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810