DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ih and Hcn3

DIOPT Version :9

Sequence 1:NP_001033948.1 Gene:Ih / 36589 FlyBaseID:FBgn0263397 Length:1327 Species:Drosophila melanogaster
Sequence 2:NP_446137.1 Gene:Hcn3 / 114245 RGDID:620691 Length:780 Species:Rattus norvegicus


Alignment Length:588 Identity:328/588 - (55%)
Similarity:423/588 - (71%) Gaps:44/588 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   684 TPKEEPMPNIPIVSEKVSANFLKS-------QLQSWFQPTDNRLAMKLFGSRKALVKERIRQKTS 741
            ||..|..|..|..:...|....:|       ||.:..|||.|:.::::|||.||:..|:.|.|::
  Rat    16 TPARETPPAAPAQARAASGGVPESAPEPKRRQLGTLLQPTVNKFSLRVFGSHKAVEIEQERVKSA 80

  Fly   742 GHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFR 806
            |.|:|||.|.|||||||.||||:|.|||:|||.|:||.::.|..||.||.||||.||:|:|:|||
  Rat    81 GAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPPWIVFNVLSDTFFLLDLVLNFR 145

  Fly   807 TGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGR 871
            |||:.::.|| ::|.|:.|...||||||.:|||||||:|||||    :::|:...|: ::....|
  Rat   146 TGIVVEEGAE-ILLAPRAIRTRYLRTWFLVDLISSIPVDYIFL----VVELEPRLDA-EVYKTAR 204

  Fly   872 ALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILK 936
            ||||:|..|:|||:||||||||:||:.||||::.:.                             
  Rat   205 ALRIVRFTKILSLLRLLRLSRLIRYMHQWEEIFHMT----------------------------- 240

  Fly   937 FLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSINELQESYWLEQYSWALFKA 1001
             .::||..:||||||.||||:.||.|||||||||||.|||:.|||:|.:....|..|||.|||||
  Rat   241 -YDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPSDCWVSMNRMVNHSWGRQYSHALFKA 304

  Fly  1002 MSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEY 1066
            ||||||||||:..|..:.|:||||||||.||||||:|:||||.||||||||||||:||.||||:|
  Rat   305 MSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQY 369

  Fly  1067 MAYRKLPRDMRQRITEYFEHRYQGKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSN 1131
            |::.|||.|.||||.||:|||||||.||||.|||||||.|||::||:.||.|||.:|.||:||.:
  Rat   370 MSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPS 434

  Fly  1132 FVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYFGEICLLTN 1196
            ||:.|:|||::|||||||::::||::|.||||||.|::. |:|.|...|.|:||||||||||||.
  Rat   435 FVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLS-VLARGARDTRLTDGSYFGEICLLTR 498

  Fly  1197 ARRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAERLNKIGKNPNIMHQKDEQLSNP 1261
            .||.|||||:|||.|:||||||||.||:::|:||:..||||.:||.:|||..:|:.:|..:.|..
  Rat   499 GRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLRRIGKKNSILQRKRSEPSPG 563

  Fly  1262 ESN 1264
            .|:
  Rat   564 SSS 566

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IhNP_001033948.1 Ion_trans_N 709..751 CDD:285597 18/41 (44%)
Ion_trans 771..1054 CDD:278921 154/282 (55%)
Crp 1118..>1241 CDD:223736 76/122 (62%)
CAP_ED 1124..1233 CDD:237999 68/108 (63%)
Hcn3NP_446137.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..47 7/30 (23%)
Involved in subunit assembly. /evidence=ECO:0000250 45..90 19/44 (43%)
Ion_trans_N 48..90 CDD:285597 18/41 (44%)
Ion_trans 110..357 CDD:278921 154/282 (55%)
Interaction with KCTD3. /evidence=ECO:0000250|UniProtKB:O88705 353..780 135/215 (63%)
Crp 421..>557 CDD:223736 82/136 (60%)
CAP_ED 427..535 CDD:237999 68/108 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 549..569 4/18 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 687..780
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166338703
Domainoid 1 1.000 178 1.000 Domainoid score I3458
eggNOG 1 0.900 - - E1_KOG0498
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000897
OrthoInspector 1 1.000 - - otm46198
orthoMCL 1 0.900 - - OOG6_101339
Panther 1 1.100 - - LDO PTHR45689
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X717
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
109.740

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