DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ih and Hcn2

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_446136.1	Gene:	Hcn2 / 114244	RGDID:	620689	Length:	863	Species:	Rattus norvegicus

Alignment Length:	592	Identity:	336/592 - (56%)
Similarity:	426/592 - (71%)	Gaps:	53/592 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   685 PKEEPMPNIPIVSEKVSANFLKSQLQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPC 749
            |..||..:        .|:||:.|..:..||..|:.::::|||:||:.:|:.|.|::|.|:|||.
  Rat   124 PAGEPRGS--------QASFLQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPY 180

  Fly   750 SSFRFYWDLCMLLLLVANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDN 814
            |.||||||..|||.:|.||||:||.|:||.|:.:..||.||.:|||.||:|:|:||||||:.:||
  Rat   181 SDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDN 245

  Fly   815 AEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLA 879
            .| :||||:.|.|.||||||.:|.:||||:||||||      ::...|| ::....|||||:|..
  Rat   246 TE-IILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLI------VEKGIDS-EVYKTARALRIVRFT 302

  Fly   880 KLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVF 944
            |:|||:||||||||:||:.||||::.:.                              .::||..
  Rat   303 KILSLLRLLRLSRLIRYIHQWEEIFHMT------------------------------YDLASAV 337

  Fly   945 MRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSINELQESYWLEQYSWALFKAMSHMLCIG 1009
            |||.|||.||||:.||.|||||||||||.|||:.|||||.:....|.|.||:|||||||||||||
  Rat   338 MRICNLISMMLLLCHWDGCLQFLVPMLQDFPSDCWVSINNMVNHSWSELYSFALFKAMSHMLCIG 402

  Fly  1010 YGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPR 1074
            |||..|:|:||:||||||||.||||||:|:||||.||||||||||||:||.||||:||::.|||.
  Rat   403 YGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPA 467

  Fly  1075 DMRQRITEYFEHRYQGKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTK 1139
            |.||:|.:|:|||||||.|||:.|||||:..|||:::|:|||.||||:|.|||||.|||:.::||
  Rat   468 DFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTK 532

  Fly  1140 LKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYFGEICLLTNARRVASVR 1204
            ||:|||||||.||:|||||.||||||.|||. |:..|.....||||||||||||||..||.||||
  Rat   533 LKFEVFQPGDYIIREGTIGKKMYFIQHGVVS-VLTKGNKEMKLSDGSYFGEICLLTRGRRTASVR 596

  Fly  1205 AETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAERLNKIG-KNPNIMHQKDEQLS-----NPES 1263
            |:|||.|:|||||:||.||::||:||:..||||.:||::|| ||..::|:....||     |.|:
  Rat   597 ADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLSSGVFNNQEN 661

  Fly  1264 NTITAVV 1270
            ..|..:|
  Rat   662 AIIQEIV 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	16/41 (39%)
		Ion_trans	771..1054	CDD:278921	159/282 (56%)
		Crp	1118..>1241	CDD:223736	84/122 (69%)
		CAP_ED	1124..1233	CDD:237999	75/108 (69%)
Hcn2	NP_446136.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..131		3/6 (50%)
		Involved in subunit assembly. /evidence=ECO:0000250	131..182		20/58 (34%)
		Ion_trans_N	140..182	CDD:285597	16/41 (39%)
		Ion_trans	202..447	CDD:278921	159/282 (56%)
		Crp	511..>646	CDD:223736	90/135 (67%)
		CAP_ED	517..625	CDD:237999	75/108 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	730..863
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	178	1.000	Domainoid score	I3458
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000897
OrthoInspector	1	1.000	-	-		otm46198
orthoMCL	1	0.900	-	-		OOG6_101339
Panther	1	1.100	-	-	O	PTHR45689
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X717
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.810