DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ih and Kcnh4

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_446082.2	Gene:	Kcnh4 / 114032	RGDID:	621415	Length:	1016	Species:	Rattus norvegicus

Alignment Length:	639	Identity:	148/639 - (23%)
Similarity:	258/639 - (40%)	Gaps:	171/639 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   688 EPMPNIPIVSEKVSANFLKSQLQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSSF 752
            ||.|::|  ..||::                     :.|||..|:          |:.|.
  Rat   199 EPKPSVP--EYKVAS---------------------VGGSRCLLL----------HYSIP----- 225

  Fly   753 RFYWDLCMLLLLVANLIILPVAISFFNDD----LSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQD 813
            :..||..:||......:.:|..:.|..||    .|...:..:...:.:|::||::||||..:.|.
  Rat   226 KAVWDGLILLATFYVAVTVPYNVCFAGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQS 290

  Fly   814 NAEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRL 878
            .  ||:..|:.|..|||.||||:|||:::|.|.:: :||                    :.:..|
  Rat   291 G--QVVSAPRSIGLHYLATWFFVDLIAALPFDLLY-VFN--------------------ITVTSL 332

  Fly   879 AKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASV 943
            ..||..||||||.||            ||.|::.|               ..|.::|..|
  Rat   333 VHLLKTVRLLRLLRL------------LQKLERYS---------------QCSAVVLTLL----- 365

  Fly   944 FMRIFNLICMMLLIGHWSGCLQFLV---------PMLQGFPSNSWVSI--NELQESY-------- 989
             |.:|      .|:.||..|:.:::         |:|...   .|:..  ..|:|.|
  Rat   366 -MSVF------ALLAHWMACVWYVIGRREMEANDPLLWDI---GWLHELGKRLEEPYVNGSAGGP 420

  Fly   990 -WLEQYSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSR 1053
             ....|..||:..:|.:..:|:|.....:..:...::.:|:.||..:|:..|:.|.:||.:.|.|
  Rat   421 SRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRR 485

  Fly  1054 RQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRYQ-GKFFDEELILGELSEKLREDVINYNCRS 1117
            ..|..::|.:::::...:|||.::||:.|||:..:. ....|...:|.:..::||.|:..:..|.
  Rat   486 SLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNRE 550

  Fly  1118 LVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATSL 1182
            :: .:|.|..|....:..:...:|.....||:.:::.|......|::..|.::::..| .|...|
  Rat   551 IL-QLPLFGAASRGCLRALSLHIKTSFCAPGEFLLRRGDALQAHYYVCSGSLEVLRDN-TVLAIL 613

  Fly  1183 SDGSYFG----EI---------CLLTNARRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTME 1234
            ..|...|    |:         |:|..:   |.|:|.|||.|..||......||..||      |
  Rat   614 GKGDLIGADIPELGQEPGAGAGCVLKTS---ADVKALTYCGLQQLSSRGLAEVLRLYP------E 669

  Fly  1235 TVAAER-------------------LNKIGKNPNIMHQKDEQLSNPESNTITAV 1269
            .|||.|                   |.:..::|.:...:.:.|.:....|:.::
  Rat   670 YVAAFRAGLPRDLTFNLRQGSENNGLGRFSRSPRLSQARSDTLGSSSDKTLPSI 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	6/41 (15%)
		Ion_trans	771..1054	CDD:278921	76/306 (25%)
		Crp	1118..>1241	CDD:223736	35/154 (23%)
		CAP_ED	1124..1233	CDD:237999	29/121 (24%)
Kcnh4	NP_446082.2	PRK13559	41..>134	CDD:237427
		PLN03192	177..>620	CDD:215625	122/525 (23%)
		Selectivity filter. /evidence=ECO:0000250	439..444		1/4 (25%)
		CAP_ED	578..667	CDD:412130	24/92 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	689..748		4/35 (11%)
		PHA03247	<732..1007	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	770..869
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	971..1016
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810