DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ih and Kcnh4

DIOPT Version :10

Sequence 1:NP_001033948.1 Gene:Ih / 36589 FlyBaseID:FBgn0263397 Length:1327 Species:Drosophila melanogaster
Sequence 2:NP_446082.2 Gene:Kcnh4 / 114032 RGDID:621415 Length:1016 Species:Rattus norvegicus


Alignment Length:639 Identity:148/639 - (23%)
Similarity:258/639 - (40%) Gaps:171/639 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   688 EPMPNIPIVSEKVSANFLKSQLQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSSF 752
            ||.|::|  ..||::                     :.|||..|:          |:.|.     
  Rat   199 EPKPSVP--EYKVAS---------------------VGGSRCLLL----------HYSIP----- 225

  Fly   753 RFYWDLCMLLLLVANLIILPVAISFFNDD----LSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQD 813
            :..||..:||......:.:|..:.|..||    .|...:..:...:.:|::||::||||..:.|.
  Rat   226 KAVWDGLILLATFYVAVTVPYNVCFAGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQS 290

  Fly   814 NAEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRL 878
            .  ||:..|:.|..|||.||||:|||:::|.|.:: :||                    :.:..|
  Rat   291 G--QVVSAPRSIGLHYLATWFFVDLIAALPFDLLY-VFN--------------------ITVTSL 332

  Fly   879 AKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASV 943
            ..||..||||||.||            ||.|::.|               ..|.::|..|     
  Rat   333 VHLLKTVRLLRLLRL------------LQKLERYS---------------QCSAVVLTLL----- 365

  Fly   944 FMRIFNLICMMLLIGHWSGCLQFLV---------PMLQGFPSNSWVSI--NELQESY-------- 989
             |.:|      .|:.||..|:.:::         |:|...   .|:..  ..|:|.|        
  Rat   366 -MSVF------ALLAHWMACVWYVIGRREMEANDPLLWDI---GWLHELGKRLEEPYVNGSAGGP 420

  Fly   990 -WLEQYSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSR 1053
             ....|..||:..:|.:..:|:|.....:..:...::.:|:.||..:|:..|:.|.:||.:.|.|
  Rat   421 SRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRR 485

  Fly  1054 RQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRYQ-GKFFDEELILGELSEKLREDVINYNCRS 1117
            ..|..::|.:::::...:|||.::||:.|||:..:. ....|...:|.:..::||.|:..:..|.
  Rat   486 SLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNRE 550

  Fly  1118 LVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATSL 1182
            :: .:|.|..|....:..:...:|.....||:.:::.|......|::..|.::::..| .|...|
  Rat   551 IL-QLPLFGAASRGCLRALSLHIKTSFCAPGEFLLRRGDALQAHYYVCSGSLEVLRDN-TVLAIL 613

  Fly  1183 SDGSYFG----EI---------CLLTNARRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTME 1234
            ..|...|    |:         |:|..:   |.|:|.|||.|..||......||..||      |
  Rat   614 GKGDLIGADIPELGQEPGAGAGCVLKTS---ADVKALTYCGLQQLSSRGLAEVLRLYP------E 669

  Fly  1235 TVAAER-------------------LNKIGKNPNIMHQKDEQLSNPESNTITAV 1269
            .|||.|                   |.:..::|.:...:.:.|.:....|:.::
  Rat   670 YVAAFRAGLPRDLTFNLRQGSENNGLGRFSRSPRLSQARSDTLGSSSDKTLPSI 723

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IhNP_001033948.1 Ion_trans_N 709..751 CDD:400630 6/41 (15%)
PLN03192 741..>1214 CDD:215625 123/510 (24%)
Kcnh4NP_446082.2 PRK13559 41..>134 CDD:237427
PLN03192 177..>620 CDD:215625 122/525 (23%)
Selectivity filter. /evidence=ECO:0000250 439..444 1/4 (25%)
cNMP-binding domain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00060 556..620 12/64 (19%)
cNMP_binding 578..665 CDD:459637 23/90 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 689..748 4/35 (11%)
PHA03247 <732..1007 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 770..869
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 971..1016
Blue background indicates that the domain is not in the aligned region.

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