Protein Alignment Ih and cngb1

DIOPT Version :10

• Sequence 1: NP_001033948.1
• Gene: Ih / 36589
• FlyBaseID: FBgn0263397
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: XP_031757189.1
• Gene: cngb1 / 100496200
• XenbaseID: XB-GENE-980342
• Length: 1922
• Species: Xenopus tropicalis
• Alignment Length: 1439
• Identity: 279/1439 - (19%)
• Similarity: 527/1439 - (36%)
• Gaps: 327/1439 - (22%)

  Fly    21 NDQRASRDNLCPDNQQQQQQRHSHSHQHL-VRQSLVSLSNGQPAASAAPDSVSLLRAGDDQQQHP 84
            |.:....||  .|...|.:.:...:|..| :.::::.....|....:....::.::..::||..|
 Frog   536 NARDVKTDN--EDGHWQDKAKGKVAHNRLSLEETIIIKQTQQMIIKSQSLELTQIQPSEEQQNKP 598

  Fly    85 QQ-PHLQQQQQQQQHLQQQQ-QRHRSSSSRLSTSGISKQNSSDSRSGL-RILDSSHSPVSCGTQS 146
            .. ..:...:::.|.|::.| ...|.....:.|         :||..| |.|....|....|.:.
 Frog   599 DTVADMADTKERAQELKKTQCLNERDPQPEVET---------ESRMELQRQLTEDMSFQFYGCED 654

  Fly   147 VSSTGGQSALYDACHEYS--RSLSAAAAEGAASLLKSHYSDQQLAQTEPD-----PEPDP----- 199
            :     |.||:|..::..  :..|....:....|.::.|...::...|.|     .|.||
 Frog   655 I-----QQALWDEQNQQEDIKKQSFCEIQSEKELKEAQYDIDKMPTAEEDLHKTAEETDPREKIN 714

  Fly   200 --------------ERDRDRDRDRDRDR---------ERERRHLTNLNLNLSSEYD---YSGSDK 238
                          |.:...||..::.:         |:|:|.| ::::...::.|   :..:::
 Frog   715 GQLMKDTILSRENIEHNDSGDRFDEKIKKIDIDIQPIEKEQRQL-SIDMKTDAQLDEERHVQTEE 778

  Fly   239 QQLVNETYIFKCIANSPSFLRTNKIKEQSKKLRNLSLKTRTAKKKGQIISKSNAVSDNS--LHPG 301
            :....|..:.:...........::|:.:.::.:.....:...:||.:   ..|.:|.::  ::|.
 Frog   779 RHTQTEDPVCQTAEERQLSYDEDQIQTEERETQTDERFSPPVQKKSE---HENVISQHAELVYPD 840

  Fly   302 -------DKYLNLY------LVEKKHSLQPQVASTSSSINTTHPQASSAPASSSSTCTKAPQLPA 353
                   ::...:|      .:|.||.        :|....|..|:......:..   |..||..
 Frog   841 KDAPYKKNECQEIYEVPQHNFIESKHE--------ASESQLTEQQSQDQEFQNDK---KEAQLEE 894

  Fly   354 LSAVAARQQQLLLNGSLKGKGQSQSQGQSRQTLPGHRASVRSESGSGSSHTI-PATGKSPPVPHS 417
            ::....|..|......|..|.::|::.:.:..  ..:..::||........| |..|:.....|.
 Frog   895 VNQNLERAMQNEKKMCLSEKTENQTEEEDKSN--EEKKYIQSEEEKNIEKEIFPKPGEQSVTEHV 957

  Fly   418 LAAKISSSASGSKNCNL-LSASSNSCHKLNAHAQGSGAGSGSGSGSGSGPPGHSHY-------AA 474
            .......:...|....: .|...:|..:.....:...............|...|:|       .|
 Frog   958 NQTDEERTVQSSVEIQIHYSQKRDSLEQQKIQIEEEVMNEVLRKDQNIIPEIDSNYDRNHEKEVA 1022

  Fly   475 ASPKSSVSSN-----------------GHLNKYC---------------LTDLTR---RKAE--- 501
            .:|: ::||:                 .|:...|               ||.|.:   :|.|
 Frog  1023 LTPE-AISSDQVKKELEDKDLVPVEEASHIETECSHEVMQYGDLTCDSALTTLLKSDDQKEEKGV 1086

  Fly   502 -------FNRQLSAPTDYTHHSSS---NGSQQEGSSEANEGHEPVGE-------STITVASAGV- 548
                   .|.:||..|:.....:.   :..|.|...|....||.:.|       :::.||:..|
 Frog  1087 EKEVLESENERLSWITEEDEDETELQVSYYQSESEEEIKVSHEVILEAPPEYLDTSVVVATQAVE 1151

  Fly   549 ----------------SYPHPYSYPYHYAHHASSATAPANLKASLQLHSFGSHHPCPYPARPTST 597
                            |.|.|...|:.:...:.......::..:|:...|....|.|...|..:.
 Frog  1152 ETNYLKQFPVQIAGTLSLPEPDGGPFMHPAVSVEDVDSGSITDALEHEDFVRPPPSPCKHRTLTV 1216

  Fly   598 SCTN--SFNRRHIRRHKGKLGDRLLSGDSEESVRCSYCSVLNVNDNDLRISFENTCTDSLVTAFD 660
            ..|:  :.:|:..:..:..:.:...:...:|.|.....|.::   :...|..|.  ...||..|.
 Frog  1217 PVTSLPAKSRKRTQSQEDIMEEMSDAAPEDEEVMERSASAIS---HSSAIITER--LQELVRMFK 1276

  Fly   661 D------EALLICDQGTEMVHFDDVSLYGTPKEE-----PMPNIPIVSEKVSAN----------- 703
            |      |.|:..:..:|     |.|...:|.::     |.|..|...:||...
 Frog  1277 DRTERVKEKLIDPELSSE-----DESPSASPSKKSAPPPPPPPPPAEEKKVEVEAQAEEEHYCEM 1336

  Fly   704 -FLKSQLQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSSFRF-YWDLCMLLLLVA 766
             ..|.:.:.|   .|..|.:|...|                  |.|.::..: .|...::|....
 Frog  1337 LCCKFKTRPW---RDRLLKLKFPSS------------------IDPLTNVMYVLWLFFVVLAWNW 1380

  Fly   767 NLIILPVAISFFNDDLST--RWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHY 829
            |..::||..:|.....|.  .|:..:.|.|.|:|:||.| |::. :|......:|.:.|.:.:||
 Frog  1381 NCWLIPVRWAFPYQTPSNIHYWLLMDYLCDLIYLLDITV-FQSR-LQFVRGGDIITNKKDMREHY 1443

  Fly   830 LRT-WFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRL 893
            .:: .|.:||||.:|||.::|.|                               .:..||||.|:
 Frog  1444 FKSERFKMDLISLLPLDLLYLKF-------------------------------GVKSLLRLPRI 1477

  Fly   894 VRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIG 958
            ::|::.:|                            .:|.:...|:.|.:: |:......:|...
 Frog  1478 LKYMAFFE----------------------------FNNRLEAILSKAYIY-RVIRTTAYLLYCL 1513

  Fly   959 HWSGCLQFLVPMLQGFPSNSWVSINELQESYWLEQYSWALFKAMSHMLCIGYGRFPPQSLTDMWL 1023
            |.:.||.:.....:|..|..|| .:.:..|| :..|.|    |:..::.|| |...|.:|.::|.
 Frog  1514 HMNACLYYWASDYEGLSSTPWV-FDGVGNSY-IRCYYW----AVKTLITIG-GLPDPDTLFELWF 1571

  Fly  1024 TMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRY 1088
            .:|:...|...:::.:|...:::.:..:.:..||..:....:||...|:||.::.|:..::|:.:
 Frog  1572 QLLNYFMGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTIKYMNCYKIPRSVQNRVKMWYEYTW 1636

  Fly  1089 QGK-FFDEELILGELSEKLREDV---INYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGD 1149
            |.: ..||..::.:|.:|:|.|:   :||   |:|:.|..|...|...:.|::.:|:..|:.|||
 Frog  1637 QSQGMLDESELMVQLPDKMRLDLAIDVNY---SIVSKVILFQGCDRQMIYDMLKRLRSVVYLPGD 1698

  Fly  1150 IIIKEGTIGTKMYFIQEGVVDIVMA-NGE-VATSLSDGSYFGEICLLT---NARRVASVRAETYC 1209
            .:.|:|.||.:||.|:.|.|.::.. :|: |..||..||.||||.||.   ..||.|:|.|..:.
 Frog  1699 YVCKKGEIGREMYIIKAGQVQVLGGPDGKTVLVSLKAGSVFGEISLLAVGGGNRRTANVVAHGFT 1763

  Fly  1210 NLFSLSVDHFNCVLDQYPLMRKTMETVAAERLNKIGKNPNIMHQKDE--------QLSNPESNTI 1266
            |||.|.....|.:|..||..:|.:...|.:.|....|      .|||        .:..|...|.
 Frog  1764 NLFILDKKDLNEILLHYPESQKLLRKKAKKMLKNSSK------PKDEPGQEKGFLHIIPPRPETP 1822

  Fly  1267 TAVVNALAA 1275
            ..:..|:||
 Frog  1823 KLLKAAIAA 1831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:400630	7/41 (17%)
		PLN03192	741..>1214	CDD:215625	124/485 (26%)
cngb1	XP_031757189.1	PTZ00121	<507..1098	CDD:173412	89/595 (15%)
		PLN03192	1359..>1745	CDD:215625	114/457 (25%)
		CAP_ED	1673..1782	CDD:237999	41/108 (38%)