Protein Alignment Ih and kcnh4

DIOPT Version :10

• Sequence 1: NP_001033948.1
• Gene: Ih / 36589
• FlyBaseID: FBgn0263397
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: XP_002942364.2
• Gene: kcnh4 / 100488431
• XenbaseID: XB-GENE-1014062
• Length: 1074
• Species: Xenopus tropicalis
• Alignment Length: 701
• Identity: 159/701 - (22%)
• Similarity: 276/701 - (39%)
• Gaps: 186/701 - (26%)

  Fly   682 YGTPKEEPMPNIPIVSEKVSANFLKSQLQS------------WFQPTDNRLAMKLFGSRKALVKE 734
            |...|||...|    ....|::|..|:.||            ....:|.:|...|..::.:|.:.
 Frog   142 YSDKKEEKHKN----RRSGSSHFRSSRRQSRTMMCQMSGQVAGRNKSDLKLNSNLLDNKPSLPEY 202

  Fly   735 RIRQKTSGHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISFFNDDLSTRWIAFNCLSD----T 795
            ::.......:::...|.|:..||..:||......:.:|..:.|...|.|........:||    .
 Frog   203 KVASAEKPRFILLHYSIFKALWDWLILLATFYVAVTVPYNVCFTGHDDSVSAARSTIVSDIAVEM 267

  Fly   796 IFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQIMKLQDF 860
            :|:|||::||||..:  .::.||:.:.:.|..|||.||||:|||:::|.|.:: .||
 Frog   268 LFIIDIILNFRTTYV--SHSGQVVYETRSICIHYLATWFFVDLIAALPFDLLY-AFN-------- 321

  Fly   861 SDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRKDK 925
                        :.:..|..||..:|||||.||::.:.::.:.
 Frog   322 ------------VTVTSLVHLLKTIRLLRLLRLLQKLDRYSQY---------------------- 352

  Fly   926 DGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSN---SWVSINELQE 987
                 |.::|..            |:.|..|:.||..|:.:::...: ..||   :|       :
 Frog   353 -----SAMVLTL------------LMSMFALLAHWMACVWYVIGRKE-MESNDPVTW-------D 392

  Fly   988 SYWLEQ----------------------YSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMIS 1030
            ..||.:                      |..:|:..:|.:..:|:|.....:..:...::.:|:.
 Frog   393 IGWLHELGKRLEAPYINNSIGGPSIRSAYIASLYFTLSSLTSVGFGNVCANTDAEKIFSICTMLI 457

  Fly  1031 GATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRYQ-GKFFD 1094
            ||..:|:..|:.|.:||.:.|.|..|..:||.:::::....||:.::||..|||:..:. ....|
 Frog   458 GALMHAVVFGNVTAIIQRMYSRRSLYHTRVKDLKDFIRVHCLPQQLKQRTLEYFQTTWSVNNGID 522

  Fly  1095 EELILGELSEKLREDV-INYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIG 1158
            ...:|.:..::||.|: ::.|...|..||  |..|....:..:...:|.....||:.::::|...
 Frog   523 ANELLKDFPDELRADIAMHLNKDILQLSV--FETASRGCLRALSLHIKTSFCAPGEYLLRQGDAL 585

  Fly  1159 TKMYFIQEGVVDIVMANGEVATSLSDGSYFGEICLLTNARRV----ASVRAETYCNLFSLSVDHF 1219
            ...||:..|.::::..| .|...|..|...|  ..|:|..:|    |.|:|.|||:|..||:...
 Frog   586 QANYFVCSGSLEVLKDN-MVLAILGKGDLIG--ADLSNKDQVIKTNADVKALTYCDLQYLSLRGL 647

  Fly  1220 NCVLDQYPLMRKTMETVAAERLNKIGKNPNIMHQKDEQLSNPESNTITAVVNALAAEADDCKDDD 1284
            ..||:.||           |..||.  ..:|.|
 Frog   648 LEVLELYP-----------EYCNKF--RADIHH-------------------------------- 667

  Fly  1285 MDLKENLLHGSESS-----IAEPVQTIREGLPRPRSG-----EFRALFEGN 1325
             ||..||..|||::     ...|    |...|||.||     :..::.|.|
 Frog   668 -DLTFNLREGSETNGCYRFSRSP----RLSQPRPESGATPEKKLASILEDN 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:400630	6/53 (11%)
		PLN03192	741..>1214	CDD:215625	118/507 (23%)
kcnh4	XP_002942364.2	PAS_9	40..135	CDD:463873
		PLN03192	224..>615	CDD:215625	105/463 (23%)
		PRK11753	578..>656	CDD:236969	25/91 (27%)