Protein Alignment Ih and hcn2

DIOPT Version :10

• Sequence 1: NP_001033948.1
• Gene: Ih / 36589
• FlyBaseID: FBgn0263397
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: XP_031761796.1
• Gene: hcn2 / 100487897
• XenbaseID: XB-GENE-1218175
• Length: 923
• Species: Xenopus tropicalis
• Alignment Length: 631
• Identity: 349/631 - (55%)
• Similarity: 452/631 - (71%)
• Gaps: 52/631 - (8%)

  Fly   698 EKVSANFLKSQLQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSSFRFYWDLCMLL 762
            ::..:.|::.||.:..||..|:.::::|||:||:.:|:.|.|::|.|:|||.|.||||||..|||
 Frog    96 DETRSGFMQRQLSAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLL 160

  Fly   763 LLVANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAK 827
            .:|.||||:||.|:||.|:.:|.||.||.:|||.||:|:|:||||||:.:||.| :||||:.|.:
 Frog   161 FMVGNLIIIPVGITFFKDETTTPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTE-IILDPQKIKR 224

  Fly   828 HYLRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSR 892
            .||||||.:|.:||||:||||||      ::...|| ::....|||||:|..|:|||:|||||||
 Frog   225 KYLRTWFVVDFVSSIPVDYIFLI------VEKGIDS-EVYKTARALRIVRFTKILSLLRLLRLSR 282

  Fly   893 LVRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNM----ASVFMRIFNLICM 953
            |:||:.||||||: :.|..:||            ||...::..|..:|    ||..|||||||.|
 Frog   283 LIRYIHQWEEVYV-EKLWTRSA------------GLFFKSVCFKIFHMTYDLASAVMRIFNLIAM 334

  Fly   954 MLLIGHWSGCLQFLVPMLQGFPSNSWVSINELQESYWLEQYSWALFKAMSHMLCIGYGRFPPQSL 1018
            |||:.||.|||||||||||.||:|.|||||::....|.|.||:||||||||||||||||..|:|:
 Frog   335 MLLLCHWDGCLQFLVPMLQDFPTNCWVSINKMVNDSWSELYSFALFKAMSHMLCIGYGRQAPESM 399

  Fly  1019 TDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEY 1083
            :|:||||||||.||||||:|:||||.||||||||||||:||.||||:||::.|||.|.|||:.:|
 Frog   400 SDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQRLHDY 464

  Fly  1084 FEHRYQGKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPG 1148
            :|||||||.|||:.|||||:|.|||:::|:|||.||||:|.|||||.:||:.::||||:|||||.
 Frog   465 YEHRYQGKMFDEDSILGELNEPLREEIVNFNCRKLVASMPLFANADPSFVTAMLTKLKFEVFQPT 529

  Fly  1149 DIIIKEGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYFGEICLLTNARRVASVRAETYCNLFS 1213
            |.||:|||||.||||||.|||. |:..|.....||||||||||||||..||.|||||:|||.|:|
 Frog   530 DYIIREGTIGKKMYFIQHGVVS-VLTKGNKEVKLSDGSYFGEICLLTRGRRTASVRADTYCRLYS 593

  Fly  1214 LSVDHFNCVLDQYPLMRKTMETVAAERLNKIG-KNPNIMHQKDEQL-----SNPESNTITAVVNA 1272
            |||||||.||::||:||:..||||.:||::|| ||..:||:....|     :|.|:..|..:|.
 Frog   594 LSVDHFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILMHKVQHDLNSGVFNNKENEIIQEIVK- 657

  Fly  1273 LAAEADDCKDDDM----DLKENLLHGSESSIAEPVQTIREGLPRPR 1314
                    .|.:|    :|.:.|..|..::...|       .|:|:
 Frog   658 --------YDREMVHQAELNQQLAGGMYATCNPP-------SPQPQ 688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:400630	17/41 (41%)
		PLN03192	741..>1214	CDD:215625	296/476 (62%)
hcn2	XP_031761796.1	PLN03192	81..>649	CDD:215625	338/574 (59%)
		CAP_ED	505..613	CDD:237999	74/108 (69%)
		Atrophin-1	<682..>846	CDD:460830	3/14 (21%)