DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ih and kcnh7

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	XP_031749023.1	Gene:	kcnh7 / 100486080	XenbaseID:	XB-GENE-853944	Length:	1205	Species:	Xenopus tropicalis

Alignment Length:	916	Identity:	211/916 - (23%)
Similarity:	358/916 - (39%)	Gaps:	239/916 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   503 NRQLSAP--------TDYTHHSSSNGSQQEGSSEANEGHEPVGESTITVA---------SAGVSY 550
            :|:.|.|        .|.:.||..:.:.:...|...|...| .|:..|.|         ...|:.
Frog   170 HRKQSLPQEDPDAVIVDSSKHSDDSMAMKHFKSPTKESCSP-SEADDTKALIDSHKCSTLVNVTG 233

  Fly   551 PHPYSYPYH--------------YAHHASSATAPANLKASLQLHSFG--SHHPCPYPARPTSTSC 599
            |..:|.|..              :..||.|..:..:::.:..:|...  |.||
Frog   234 PLDHSSPKRQWDQLFPDRLHAGSHISHARSKDSVCSMRRASSVHDIEGFSIHP------------ 286

  Fly   600 TNSFNRRHIRRHKGKLGDRLLSGDSEESVRCSYCSVLNVNDNDLRISFENTCTDSLVTAFDDEAL 664
                        |....||..|.|:....:.|:..:.....|.::.|...:.:||.:..:  ..:
Frog   287 ------------KSVFRDRHASEDNGRDFKVSHSWMTGGPFNHIKSSLLGSTSDSNLNKY--STI 337

  Fly   665 LICDQGTEMVHFDDVSLYGTPKEEPMPNIPIVSEK-VSANFLKSQLQSWFQPTDNRLAMKLFGS- 727
            ....|.|  ::|.||      |.|...:.|..||| :.|..:|.:..:..:.....|::   |:
Frog   338 NKIPQLT--LNFSDV------KNEKKASSPPSSEKTIIAPKVKERTHNVTEKVTQVLSL---GAD 391

  Fly   728 ---RKALVKERIRQKTSGHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISF-FND--DLSTRW 786
               ...|...||.:.|..|:     |.|:..||..:|||::...|..|.:.:| .||  :...|.
Frog   392 VLPEYKLQTPRINKFTILHY-----SPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRE 451

  Fly   787 IAFNC--------LSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISSIP 843
            ..::|        :.|.:|:|||::||||..:.|:  |:|:.||..||.||.:.||.:|::::||
Frog   452 CGYSCNPLNVVDLMVDIMFIIDILINFRTTYVNQN--EEVVSDPAKIAIHYFKGWFLIDMVAAIP 514

  Fly   844 LDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQN 908
            .|  .|||.      ..||....|     :.:|:.|:||.|||:.|  :|.||......|.:|
Frog   515 FD--LLIFG------SGSDETTTL-----IGLLKTARLLRLVRVAR--KLDRYSEYGAAVLML-- 562

  Fly   909 LQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQG 973
                                                     |:|:..||.||..|:
Frog   563 -----------------------------------------LMCIFALIAHWLACI--------- 577

  Fly   974 FPSNSWVSINELQESYWLEQYSW-----------------------------ALFKAMSHMLCIG 1009
                 |.:|..::..|.:.:.||                             ||:...|.:..:|
Frog   578 -----WYAIGNVERPYLIHKISWLDALGDQIKKPYNYSDPSSGPSIKDKYVTALYFTFSSLTSVG 637

  Fly  1010 YGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPR 1074
            :|...|.:.::...::..|:.|:..||...|:.:.:||.|.|...:|..::.:|:|::.:.::|.
Frog   638 FGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPN 702

  Fly  1075 DMRQRITEYFEHRYQ-GKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVT 1138
            .:|||:.|||:|.:. ....|..::|....|.|:.|:..:..::|:.:...|:.|....:..:..
Frog   703 PLRQRLEEYFQHAWSYTNGIDMNMVLKGFPECLQADICLHLNKTLLQNCKAFSGASKGCLRALAM 767

  Fly  1139 KLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYFGEICLL--TNARRVA 1201
            |.|.....|||.::..|.|.|.:||:..|.::| :.:..|...|.....|||:..|  ...:.:|
Frog   768 KFKTTHAPPGDTLVHSGDILTALYFLSRGSIEI-LKDDIVVAILGKNDIFGEMVHLYAKPGKSIA 831

  Fly  1202 SVRAETYCNLFSLSVDHFNCVLDQYP--------------LMRKTMETVAAER----LNKIGKNP 1248
            .|||.|||:|..:..:....|||.||              .:|......|..|    ::..|:|.
Frog   832 DVRALTYCDLHKIQREDLLEVLDMYPEFSDQFLTNLELTFNLRDENSKAALLRSHADIDFNGENC 896

  Fly  1249 NIMHQK-------DEQLSNPESNTITAVVNALAAEADDCKD-----DDMDLKENLLHGSESSIAE 1301
            .:..:|       ||..|..||.      |...:..||.::     .:||:|::  ..|.|||.|
Frog   897 KLRRRKLSFKNKSDEDCSRDESQ------NGSESSTDDTRNYSSTKKNMDIKKS--GSSSSSINE 953

  Fly  1302 --PVQT 1305
              |:.|
Frog   954 TKPLYT 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	7/45 (16%)
		Ion_trans	771..1054	CDD:278921	76/322 (24%)
		Crp	1118..>1241	CDD:223736	37/142 (26%)
		CAP_ED	1124..1233	CDD:237999	34/124 (27%)
kcnh7	XP_031749023.1	PAS_9	29..134	CDD:404329
		Ion_trans	417..679	CDD:395416	81/335 (24%)
		CAP_ED	753..864	CDD:237999	33/111 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910