DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ih and HCN4

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_005468.1	Gene:	HCN4 / 10021	HGNCID:	16882	Length:	1203	Species:	Homo sapiens

Alignment Length:	954	Identity:	392/954 - (41%)
Similarity:	510/954 - (53%)	Gaps:	232/954 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 SQSQGQSRQTLPGHRASVR---------SESGSGSSHTIPATGKSPPVPHSLAAKISSSASGSKN 431
            ::.:|...:..|..| |:|         |.:..|:.....|.|         ||.....|.|:..
Human    32 AEEEGAGGRQDPSRR-SIRLRPLPSPSPSAAAGGTESRSSALG---------AADSEGPARGAGK 86

  Fly   432 CNLLSASSNSCHKLNAHAQGSGAGSGSGSGSGSGPPGHSHYAAASPKSSVSSNGHLNKYCLTDLT 496
                |:::..|.:........|:..|...|:|||                ||:|||:.
Human    87 ----SSTNGDCRRFRGSLASLGSRGGGSGGTGSG----------------SSHGHLHD------- 124

  Fly   497 RRKAEFNRQLSAPTDYTHHSSSNGSQQEGSSEANEGHEPVGESTITVASAGVSYPHPYSYPYHYA 561
              .||..|.::                ||.:...|...|.|
Human   125 --SAEERRLIA----------------EGDASPGEDRTPPG------------------------ 147

  Fly   562 HHASSATAPANLKASLQLHSFGSHHPCPYPARPTSTSCTNSFNRRHIRRHKG-KLGDRLLSGDSE 625
                .|..|....||.|  ...|..|...|.:|.|.||........|:...| ..||::|   .|
Human   148 ----LAAEPERPGASAQ--PAASPPPPQQPPQPASASCEQPSVDTAIKVEGGAAAGDQIL---PE 203

  Fly   626 ESVRCSYCSVLNVNDNDLRISFENTCTDSLVTAFDDEALLICDQGTEMVHFDDVSLYGTPKEEPM 690
            ..||..
Human   204 AEVRLG----------------------------------------------------------- 209

  Fly   691 PNIPIVSEKVSANFLKSQLQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSSFRFY 755
                      .|.|::.|..:..||..|:.::::|||:||:.:|:.|.|::|.|:|||.|.||||
Human   210 ----------QAGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFY 264

  Fly   756 WDLCMLLLLVANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVIL 820
            |||.||||:|.||||:||.|:||.|:.:|.||.||.:|||.||||:|:||||||:.:||.| :||
Human   265 WDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTE-IIL 328

  Fly   821 DPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLV 885
            ||:.|...||::||.:|.|||||:||||||      ::...|| ::....|||||:|..|:|||:
Human   329 DPQRIKMKYLKSWFMVDFISSIPVDYIFLI------VETRIDS-EVYKTARALRIVRFTKILSLL 386

  Fly   886 RLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNL 950
            ||||||||:||:.||||::.:.                              .::||..:||.||
Human   387 RLLRLSRLIRYIHQWEEIFHMT------------------------------YDLASAVVRIVNL 421

  Fly   951 ICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSINELQESYWLEQYSWALFKAMSHMLCIGYGRFPP 1015
            |.||||:.||.|||||||||||.||.:.|||||.:..:.|.:|||:||||||||||||||||..|
Human   422 IGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAP 486

  Fly  1016 QSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRI 1080
            ..::|:||||||||.||||||:|:||||.||||||||||||:||.||||:||::.|||.|.||||
Human   487 VGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRI 551

  Fly  1081 TEYFEHRYQGKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVF 1145
            .:|:|||||||.||||.|||||||.|||::||:|||.||||:|.|||||.|||:.::|||::|||
Human   552 HDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVF 616

  Fly  1146 QPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYFGEICLLTNARRVASVRAETYCN 1210
            ||||.||:|||||.||||||.|||. |:..|...|.|:||||||||||||..||.|||||:|||.
Human   617 QPGDYIIREGTIGKKMYFIQHGVVS-VLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCR 680

  Fly  1211 LFSLSVDHFNCVLDQYPLMRKTMETVAAERLNKIGKNPNIM-----HQKDEQLSNPESNTITAVV 1270
            |:|||||:||.||::||:||:..||||.:||::|||..:|:     |..:..:.|.:.|.|
Human   681 LYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEI---- 741

  Fly  1271 NALAAEADDCKDDDMDLKENLLHGSE-SSIAEPVQTIREGLPRP 1313
                            :::.:.|..| :..|..||......|.|
Human   742 ----------------IQQIVQHDREMAHCAHRVQAAASATPTP 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	16/41 (39%)
		Ion_trans	771..1054	CDD:278921	155/282 (55%)
		Crp	1118..>1241	CDD:223736	83/122 (68%)
		CAP_ED	1124..1233	CDD:237999	74/108 (69%)
HCN4	NP_005468.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..182		46/234 (20%)
		Involved in subunit assembly. /evidence=ECO:0000250	209..260		19/119 (16%)
		Ion_trans_N	218..260	CDD:285597	16/41 (39%)
		Ion_trans	280..525	CDD:278921	155/282 (55%)
		Crp	589..>724	CDD:223736	89/135 (66%)
		CAP_ED	595..703	CDD:237999	74/108 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	836..856
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	870..897
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..1203
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	178	1.000	Domainoid score	I3565
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000897
OrthoInspector	1	1.000	-	-		otm42053
orthoMCL	1	0.900	-	-		OOG6_101339
Panther	1	1.100	-	-	O	PTHR45689
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8291
SonicParanoid	1	1.000	-	-		X717
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.840