DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ih and kcnh4a

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	NP_001309362.1	Gene:	kcnh4a / 100148126	ZFINID:	ZDB-GENE-131125-34	Length:	1151	Species:	Danio rerio

Alignment Length:	865	Identity:	189/865 - (21%)
Similarity:	325/865 - (37%)	Gaps:	264/865 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   601 NSFNRRHIRRHKGKLGDRLLSGDSEES-----VRCS--YCSVLNVNDNDLRISFENTC------- 651
            |:|.....:|..|...:.|| |:::.|     |.||  :|.:......::   .:.||
Zfish    12 NTFLDTIAKRFDGTHSNFLL-GNAQGSRGYPIVYCSDGFCELTGFARTEV---MKKTCTCQFLHG 72

  Fly   652 --TDSLVT-----------AFDDEALLICDQGTEMVHFDDVSLYGTPKEEPMPNIPIVSEK---- 699
              |...||           .|..|.......||......|:             :||.:||
Zfish    73 QETSERVTQQVEKTLEGQREFQTEVCYYRKNGTTFWCLLDI-------------VPIKNEKGEVV 124

  Fly   700 --------VSANFLKSQLQSWFQPTDNRLAMKLFGSRKALVKERIR------------------- 737
                    ::.::.||.|.|..: .|.|...|:..:..:..:||.|
Zfish   125 LFLLSFKNITDSYGKSHLGSSTE-EDRRHGRKVGRTHLSQARERGRNVLYHLTCQFTNRSKRKLP 188

  Fly   738 -----QKTSGHWVIHPCSSFRF----------YWDLCMLLLLVANLIILPVAISFFN-------- 779
                 |.|...:.:......||          .||..:||......:.:|..:.|..
Zfish   189 NNVFSQPTLPEYKVASVQKSRFILLHYSVCKAMWDWLILLATFYVAVTVPYNVCFSTPDDSQLDS 253

  Fly   780 ---DDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISS 841
               |..|...|..:...:.:|::||::||||..:  ..|.||:.|.:.|..||..|||.||||::
Zfish   254 PDCDSSSRTTIVSDIAVEMLFILDIILNFRTTYV--GPAGQVVYDTRSICLHYCTTWFILDLIAA 316

  Fly   842 IPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYIL 906
            :|.|.::| ||                    :.:..|..||..||||||.||            |
Zfish   317 LPFDLLYL-FN--------------------ISVTSLVHLLKTVRLLRLLRL------------L 348

  Fly   907 QNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPML 971
            |.|                ||.::.:.::..|.| |||          .|:.||..|:.:::..
Zfish   349 QKL----------------DGYSQYSAVVLTLLM-SVF----------ALLAHWLACVWYVIGR- 385

  Fly   972 QGFPSN---SWVSINELQESYWLEQ----------------------YSWALFKAMSHMLCIGYG 1011
            |...||   :|       :..||::                      |..:|:..:|.:..:|:|
Zfish   386 QELASNDPLTW-------DIGWLQELGKRLETPYTNGTVGGPSLRSAYIASLYFTLSSLTSVGFG 443

  Fly  1012 RFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDM 1076
            .....:..:...::.:|:.||..:|:..|:.|.:||.:.|.|..|..::|.:::::...:||:.:
Zfish   444 NVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHTRMKDLKDFIRVHRLPQQL 508

  Fly  1077 RQRITEYFEHRYQ-GKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKL 1140
            :||:.|||:..:. ....:...:|.:..::||.|:..:..:.:: .:|.|::|....:..:...:
Zfish   509 KQRMLEYFQTTWSVNNGINANELLHDFPDELRADIAMHLNKDIL-QLPLFSSASRGCLRSLSLHI 572

  Fly  1141 KYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYFG------EICLLTNARR 1199
            |.....||:.:|:.|......:|:..|.:: |:.:|.|...|..|...|      :..:..|
Zfish   573 KTSFCAPGEYLIRHGDALHAQHFVCSGSLE-VLKDGMVLAILGKGDLVGADLPGKDQVIKAN--- 633

  Fly  1200 VASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAERLNKIGK--NPNIMHQKDEQLSNPE 1262
             |.|:|.|||:|..:||.....||:.||               :.|.  |.:|.|.....|...:
Zfish   634 -ADVKALTYCDLQYISVRALQEVLELYP---------------EYGSRFNEDIHHNLTYNLREGQ 682

  Fly  1263 SNTITAVVNALAAEA-DDCK---------DDD--MDL-KENLLHG-----SESSIA--------- 1300
            :....:  ..||.|. |:||         :||  .|| :..||.|     |:|:::
Zfish   683 ARFSRS--TRLAQEKFDECKLPFIVETEQEDDTGQDLGRRPLLSGFSCPSSQSNLSAMLGEEFRH 745

  Fly  1301 --------EPVQTIREGLPR 1312
                    .|||:.|...|:
Zfish   746 HNMLRFCRSPVQSSRIQSPQ 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	10/65 (15%)
		Ion_trans	771..1054	CDD:278921	76/318 (24%)
		Crp	1118..>1241	CDD:223736	30/128 (23%)
		CAP_ED	1124..1233	CDD:237999	29/114 (25%)
kcnh4a	NP_001309362.1	PAS	42..133	CDD:238075	18/106 (17%)
		PAS_3	42..127	CDD:285623	18/100 (18%)
		Ion_trans	267..486	CDD:278921	71/288 (25%)
		Ion_trans_2	<426..480	CDD:285168	12/53 (23%)
		Crp	553..745	CDD:223736	50/213 (23%)
		CAP_ED	556..666	CDD:237999	30/129 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910