Protein Alignment Ih and kcnh4a

DIOPT Version :10

• Sequence 1: NP_001033948.1
• Gene: Ih / 36589
• FlyBaseID: FBgn0263397
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: NP_001309362.1
• Gene: kcnh4a / 100148126
• ZFINID: ZDB-GENE-131125-34
• Length: 1151
• Species: Danio rerio
• Alignment Length: 865
• Identity: 189/865 - (21%)
• Similarity: 325/865 - (37%)
• Gaps: 264/865 - (30%)

  Fly   601 NSFNRRHIRRHKGKLGDRLLSGDSEES-----VRCS--YCSVLNVNDNDLRISFENTC------- 651
            |:|.....:|..|...:.|| |:::.|     |.||  :|.:......::   .:.||
Zfish    12 NTFLDTIAKRFDGTHSNFLL-GNAQGSRGYPIVYCSDGFCELTGFARTEV---MKKTCTCQFLHG 72

  Fly   652 --TDSLVT-----------AFDDEALLICDQGTEMVHFDDVSLYGTPKEEPMPNIPIVSEK---- 699
              |...||           .|..|.......||......|:             :||.:||
Zfish    73 QETSERVTQQVEKTLEGQREFQTEVCYYRKNGTTFWCLLDI-------------VPIKNEKGEVV 124

  Fly   700 --------VSANFLKSQLQSWFQPTDNRLAMKLFGSRKALVKERIR------------------- 737
                    ::.::.||.|.|..: .|.|...|:..:..:..:||.|
Zfish   125 LFLLSFKNITDSYGKSHLGSSTE-EDRRHGRKVGRTHLSQARERGRNVLYHLTCQFTNRSKRKLP 188

  Fly   738 -----QKTSGHWVIHPCSSFRF----------YWDLCMLLLLVANLIILPVAISFFN-------- 779
                 |.|...:.:......||          .||..:||......:.:|..:.|..
Zfish   189 NNVFSQPTLPEYKVASVQKSRFILLHYSVCKAMWDWLILLATFYVAVTVPYNVCFSTPDDSQLDS 253

  Fly   780 ---DDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISS 841
               |..|...|..:...:.:|::||::||||..:  ..|.||:.|.:.|..||..|||.||||::
Zfish   254 PDCDSSSRTTIVSDIAVEMLFILDIILNFRTTYV--GPAGQVVYDTRSICLHYCTTWFILDLIAA 316

  Fly   842 IPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYIL 906
            :|.|.::| ||                    :.:..|..||..||||||.||            |
Zfish   317 LPFDLLYL-FN--------------------ISVTSLVHLLKTVRLLRLLRL------------L 348

  Fly   907 QNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPML 971
            |.|                ||.::.:.::..|.| |||          .|:.||..|:.:::..
Zfish   349 QKL----------------DGYSQYSAVVLTLLM-SVF----------ALLAHWLACVWYVIGR- 385

  Fly   972 QGFPSN---SWVSINELQESYWLEQ----------------------YSWALFKAMSHMLCIGYG 1011
            |...||   :|       :..||::                      |..:|:..:|.:..:|:|
Zfish   386 QELASNDPLTW-------DIGWLQELGKRLETPYTNGTVGGPSLRSAYIASLYFTLSSLTSVGFG 443

  Fly  1012 RFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDM 1076
            .....:..:...::.:|:.||..:|:..|:.|.:||.:.|.|..|..::|.:::::...:||:.:
Zfish   444 NVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHTRMKDLKDFIRVHRLPQQL 508

  Fly  1077 RQRITEYFEHRYQ-GKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKL 1140
            :||:.|||:..:. ....:...:|.:..::||.|:..:..:.:: .:|.|::|....:..:...:
Zfish   509 KQRMLEYFQTTWSVNNGINANELLHDFPDELRADIAMHLNKDIL-QLPLFSSASRGCLRSLSLHI 572

  Fly  1141 KYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYFG------EICLLTNARR 1199
            |.....||:.:|:.|......:|:..|.:: |:.:|.|...|..|...|      :..:..|
Zfish   573 KTSFCAPGEYLIRHGDALHAQHFVCSGSLE-VLKDGMVLAILGKGDLVGADLPGKDQVIKAN--- 633

  Fly  1200 VASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAERLNKIGK--NPNIMHQKDEQLSNPE 1262
             |.|:|.|||:|..:||.....||:.||               :.|.  |.:|.|.....|...:
Zfish   634 -ADVKALTYCDLQYISVRALQEVLELYP---------------EYGSRFNEDIHHNLTYNLREGQ 682

  Fly  1263 SNTITAVVNALAAEA-DDCK---------DDD--MDL-KENLLHG-----SESSIA--------- 1300
            :....:  ..||.|. |:||         :||  .|| :..||.|     |:|:::
Zfish   683 ARFSRS--TRLAQEKFDECKLPFIVETEQEDDTGQDLGRRPLLSGFSCPSSQSNLSAMLGEEFRH 745

  Fly  1301 --------EPVQTIREGLPR 1312
                    .|||:.|...|:
Zfish   746 HNMLRFCRSPVQSSRIQSPQ 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:400630	10/65 (15%)
		PLN03192	741..>1214	CDD:215625	120/525 (23%)
kcnh4a	NP_001309362.1	PAS_9	41..135	CDD:463873	18/109 (17%)
		PLN03192	222..>620	CDD:215625	109/469 (23%)
		Crp	565..740	CDD:440428	47/196 (24%)